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Biocelulose-based Cell Culture Platform

Abstract

Paper, essentially composed by cellulose, is a versatile material used in the biomedical field, specially in diagnostic tests. Currently, paper has been used in the production of cell culture platforms, which can be used to grow several cell strains. This type of device can be used, for example, to investigate cellular responses to drug administration (drug screening), as disease models for the development of suitable treatments, in cell cryopreservation, and also while scaffolds in tissue engineering. The paper surface, however, does not provide adequate cell adhesion. To overcome this issue, paper surface modification becomes an attractive alternative. In this context, bacterial cellulose appears as an interesting material, as it presents high biocompatibility, it exhibits three-dimensional architecture similar to the extracellular matrix through the presence of entangled nanofibrils and it shows more adequate physical and mechanical properties compared to vegetable cellulose. Due to the presence of hydroxyl (OH) groups on the cellulose surface, a wide variety of derivatives can be prepared by modifying its original functional group. In this sense, the present study aims to functionalize the surface of bacterial cellulose by chemical processes followed by the immobilization of growth factor, in order to obtain optimized cell cultures platforms. These platforms will be characterized by Scanning and Transmission Electron Microscopy, X-ray Diffraction, Infrared and X-ray Excited Photoelectron Spectroscopy, Thermal and Mechanical Analysis, Contact Angle and porosity determination. In order to evaluate the effectiveness of the materials produced, in vitro cell adhesion and proliferation assays will be performed. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, MOLIRIA V.; BARUD, HERNANE S.; ALENCAR, MONICA A. S.; NALIN, MARCELO; TOMA, SERGIO H.; ARAKI, KOITI; BENEDETTI, ASSIS V.; MACIEL, INDHIRA O.; FRAGNEAUD, BENJAMIN; LEGNANI, CRISTIANO; et al. Self-Supported Smart Bacterial Nanocellulose-Phosphotungstic Acid Nanocomposites for Photochromic Applications. FRONTIERS IN MATERIALS, v. 8, . (14/12424-2, 13/07793-6, 16/11591-8, 13/24725-4, 18/25512-8, 20/04509-9)
DE PAIVA, JULIANA MORENO; DE OLIVEIRA BARUD, HELIDA GOMES; FRANCO, DOUGLAS FAZA; MENEGUIN, ANDREIA BAGLIOTTI; RIBEIRO, ANTONIO JOSE; BARUD, HERNANE S.; NALIN, MARCELO. The impact of P/Ca molar ratio on physicochemical and release properties of calcium polyphosphate coacervates. Materials Chemistry and Physics, v. 264, . (13/07793-6, 18/25512-8, 18/24735-3)
MELO, PAMELA T. S.; OTONI, CAIO G.; BARUD, HERNANE S.; AOUADA, FAUZE A.; DE MOURA, MARCIA R.. Upcycling Microbial Cellulose Scraps into Nanowhiskers with Engineered Performance as Fillers in All-Cellulose Composites. ACS APPLIED MATERIALS & INTERFACES, v. 12, n. 41, p. 46661-46666, . (13/07296-2, 19/06170-1, 18/25512-8, 13/07276-1)
RIBEIRO, SABRINA DIAS; MENEGUIN, ANDREIA BAGLIOTTI; BARUD, HERNANE DA SILVA; SILVA, JHONATAN MIGUEL; OLIVEIRA, RAFAEL L.; NASCIMENTO DE ASUNCAO, ROSANA MARIA; TORMIN, THIAGO FARIA; ABARZA MUNOZ, RODRIGO ALEJANDRO; RODRIGUES FILHO, GUIMES; RIBEIRO, CLOVIS AUGUSTO. Synthesis and characterization of cellulose acetate from cellophane industry residues. Application as acetaminophen controlled-release membranes. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, . (13/07276-1, 18/25512-8, 16/15504-2)
MARTINS, LARISSA S.; SILVA, NYCOLLE G. S.; CLARO, AMANDA MARIA; AMARAL, NAYARA C.; BARUD, HERNANE S.; MULINARI, DANIELLA R.. Insight on alai seed biomass economy and waste cooking oil: Eco-sorbent castor oil-based. Journal of Environmental Management, v. 293, . (18/25512-8, 13/07276-1)
FARACO, T. A.; YOSHIOKA, N. A.; SABIO, R. M.; BARUD, H. DA S.; MACIEL, I. O.; QUIRINO, W. G.; FRAGNEAUD, B.; DE AGUIAR, A. M.; RIBEIRO, S. J. L.; CREMONA, M.; et al. Monolayer of silica nanospheres assembled onto ITO-coated glass substrates by spin-coating. Nanotechnology, v. 32, n. 20, . (20/04509-9, 18/25512-8, 13/07276-1)
MENEGUIN, ANDREIA; PACHECO, GUILHERME; SILVA, JHONATAN MIGUEL; DE ARAUJO, FRANCISCA PEREIRA; SILVA-FILHO, EDSON CAVALCANTI; BERTOLINO, LUIZ CARLOS; BARUD, HERNANE DA SILVA. Nanocellulose/palygorskite biocomposite membranes for controlled release of metronidazole. International Journal of Biological Macromolecules, v. 188, p. 689-695, . (13/07793-6, 19/19817-3, 18/25512-8)
SIMEI AQUARONI, NAYARA AP.; NAKAHATA, DOUGLAS H.; LAZARINI, SILMARA C.; RESENDE, FLAVIA A.; CANDIDO, AMANDA L. P.; BARUD, HERNANE DA SILVA; CLARO, AMANDA MARIA; DE CARVALHO, JOAO ERNESTO; RIBEIRO, CAMILA M.; PAVAN, FERNANDO R.; et al. Antibacterial activities and antiproliferative assays over a tumor cells panel of a silver complex with 4-aminobenzoic acid: Studies in vitro of sustained release using bacterial cellulose membranes as support. Journal of Inorganic Biochemistry, v. 212, . (17/19243-1, 15/09833-0, 17/16278-9, 18/12062-4, 16/07729-4, 13/07276-1, 18/12590-0, 18/25512-8, 14/06779-2, 19/03049-7, 18/02344-2, 18/00163-0, 15/20882-3)
DE FARIAS, ALINE LEITE; MENEGUIN, ANDREIA BAGLIOTTI; BARUD, HERNANE DA SILVA; BRIGHENTI, FERNANDA LOURENCAO. The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin. International Journal of Biological Macromolecules, v. 162, p. 1944-1958, . (13/12326-8, 13/07276-1, 18/25512-8)
MAIA, LANA S.; ZANINI, NOELLE C.; DE SOUZA, ALANA G.; BARBOSA, RENNAN F. S.; ROSA, DERVAL S.; DA BARUD, HERNANE S.; MULINARI, DANIELLA R.. Effective oil spill cleaned up with environmentally friendly foams filled with eucalyptus charcoal residue. IRANIAN POLYMER JOURNAL, . (18/25512-8, 13/07793-6, 18/11277-7)
DE OLIVEIRA BARUD, HELIDA GOMES; DA SILVA, ROBSON ROSA; BORGES, MARCO ANTONIO COSTA; CASTRO, GUILLERMO RAUL; RIBEIRO, SIDNEY JOSE LIMA; DA SILVA BARUD, HERNANE. Bacterial Nanocellulose in Dentistry: Perspectives and Challenges. Molecules, v. 26, n. 1, . (13/07793-6, 18/25512-8)
FERREIRA, V, FILIPE; OTONI, CAIO G.; DE FRANCE, KEVIN J.; BARUD, HERNANE S.; LONA, LILIANE M. F.; CRANSTON, EMILY D.; ROJAS, ORLANDO J.. Porous nanocellulose gels and foams: Breakthrough status in the development of scaffolds for tissue engineering. MATERIALS TODAY, v. 37, p. 126-141, . (18/25512-8, 16/09588-9, 18/16851-3, 18/12831-8)
MAIA, LANA S.; ZANINI, NOELLE C.; CLARO, AMANDA MARIA; DO AMARAL, NAYARA CAVICHIOLLI; BARUD, HERNANE S.; MULINARI, DANIELLA R.. Eco-friendly foams of castor oil based-polyurethane with Artemisia residue fillers for discarded vegetable oil sorption. Journal of Applied Polymer Science, v. 138, n. 43, . (18/25512-8, 13/07276-1)
MONTEIRO, ANDREIA S.; DE OLIVEIRA, MARCOS; SANTAGNELI, SILVIA; CARCEL, CAROLE; GUTMANN, TORSTEN; BUNTKOWSKY, GERD; MAN, MICHEL WONG CHI; BARUD, HERNANE S.; RIBEIRO, SIDNEY J. L.. Modification of Bacterial Cellulose Membrane with 1,4-Bis(triethoxysilyl)benzene: A Thorough Physical-Chemical Characterization Study. Journal of Physical Chemistry C, v. 125, n. 8, SI, p. 4498-4508, . (18/25512-8, 17/21005-1, 13/07793-6, 15/12908-2)

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