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Indole alkaloid sub products of Maqui (Aristotelia chilensis) processing as food additives to Alzheimer's Disease treatment

Grant number: 18/08426-0
Support type:Regular Research Grants
Duration: December 01, 2018 - November 30, 2022
Field of knowledge:Biological Sciences - Biochemistry
Cooperation agreement: Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)
Principal researcher:Alexander Henning Ulrich
Grantee:Alexander Henning Ulrich
Principal researcher abroad: Cristian Fabian Paz Robles
Institution abroad: Universidad de La Frontera (UFRO), Chile
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Maqui (Aristotelia chilensis) is a big business for the export of its fruit, of great antioxidant properties, which has conquered the agri-food industry. Maqui fruit and leaves have shown an important range of biological actions, including antioxidants, anti-inflammatory and analgesic, leading to obtain products as complementary therapeutic agents in the treatment of various chronic and degenerative disorders. The World Alzheimer Report (WAR) 2016 reviews research evidence that people living with dementia have poor access to appropriate healthcare and due to increasing life expectancy, the number of people with dementia is increasing. WAR 2016 estimates that 46.8 million people worldwide living with dementia in 2015 and this number will reach 131.5 million in 2050 (Prince et al. 2016).The Maqui plant has bioactive molecules that can give an added value. Studies by our group of researchers have isolated indole alkaloids that inhibit AChE, an enzyme associated with neurodegenerative diseases such as Alzheimer's. The indolic alkaloids have already been proposed as therapy against Alzheimer's, in this work we will extend the state of the art to new molecules extracted from Maqui, a plant endemic to Chile, as a nutritional supplement that retards and protects from the neurodegenerative effects of Alzheimer's disease. Dr. Paz and coworkers published in 2017 the first report of cholinesterases (AChE) inhibitors indole alkaloids from A. chilensis. This publication is considered as the starting point of this project in order to evaluate the role of this indole alkaloids in vivo, and propose it for use as functional food or nutraceuticals for aging people. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA-GIACOMELLI, AGATHA; PETIZ, LYVIA LINTZMAIER; ANDREJEW, ROBERTA; TURRINI, NATALIA; SILVA, JEAN BEZERRA; SACK, ULRICH; ULRICH, HENNING. Role of P2X7 Receptors in Immune Responses During Neurodegeneration. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 15, . (18/08426-0, 19/24553-5, 18/07366-4, 19/26852-0, 20/10725-6)
MARQUES, BRUNO LEMES; OLIVEIRA-LIMA, ONESIA CRISTINA; CARVALHO, GUSTAVO ALMEIDA; CHIARELLI, RAPHAELA DE ALMEIDA; RIBEIRO, RAUL IZIDORO; PARREIRA, RICARDO CAMBRAIA; DA MADEIRA FREITAS, ELIS MARRA; RESENDE, RODRIGO RIBEIRO; KLEMPIN, FRIEDERIKE; ULRICH, HENNING; et al. Neurobiology of glycine transporters: From molecules to behavior. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 118, p. 97-110, . (18/08426-0)
ULRICH, HENNING; PILLAT, MICHELI M.; TARNOK, ATTILA. Dengue Fever, COVID-19 (SARS-CoV-2), and Antibody-Dependent Enhancement (ADE): A Perspective. Cytometry Part A, v. 97, n. 7, SI, . (18/08426-0)
RODRIGUEZ-MASSO, SERGIO R.; ERICKSON, MICHELLE A.; BANKS, WILLIAM A.; ULRICH, HENNING; MARTINS, ANTONIO HENRIQUE. The Bradykinin B2 Receptor Agonist (NG291) Causes Rapid Onset of Transient Blood-Brain Barrier Disruption Without Evidence of Early Brain Injury. FRONTIERS IN NEUROSCIENCE, v. 15, . (18/08426-0)
ULRICH, HENNING; PILLAT, MICHELI M.. CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement. STEM CELL REVIEWS AND REPORTS, v. 16, n. 3, . (18/08426-0)
RIBEIRO, DEIDIANE ELISA; RONCALHO, ALINE LULHO; GLASER, TALITA; ULRICH, HENNING; WEGENER, GREGERS; JOCA, SAMIA. P2X7 Receptor Signaling in Stress and Depression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, . (15/13345-1, 12/50880-4, 18/08426-0)

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