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Co-regulatory studies onto mitochondrial ribosome biogenesis and cytochrome oxidase assembly


The assembly of the mitochondrial respiratory complexes depends on proteins encoded by two different genomes, an unique situation in human cells that arise our interest on regulatories mechanisms involved in the proper steichiometric assembly of the respiratory complexes. Here, we propose to study a possible regulatory interconnection between cytochrome c oxidase (COX) assembly and the mitoribosome. Interactions of COX assembly factors, such as Cox14p and Coa3p, with mitoribosome proteins (e.g. mL38) will be explored through pull down assays in different mutant variants of these genes. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARROS, MARIO H.; MCSTAY, GAVIN P.. Modular biogenesis of mitochondrial respiratory complexes. MITOCHONDRION, v. 50, p. 94-114, . (19/05232-3)

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