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Development of a two-dimensional extraction, separation and analysis system for evaluating the bioactivity of phytochemicals

Grant number: 18/14582-5
Support Opportunities:Research Grants - Young Investigators Grants - Phase 2
Duration: May 01, 2019 - April 30, 2025
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Engineering
Principal Investigator:Maurício Ariel Rostagno
Grantee:Maurício Ariel Rostagno
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated researchers:Adriane Elisabete Antunes de Moraes ; Ana Carolina de Aguiar ; Augusto Ducati Luchessi ; Diogo Thimoteo da Cunha ; Fernando Moreira Simabuco ; Julian Martínez ; Rosângela Maria Neves Bezerra ; Tânia Forster Carneiro
Associated research grant:13/04304-4 - Development of integrated systems for the analysis of bioactive compounds in natural products employing supercritical technology, AP.JP
Associated grant(s):23/07411-8 - VI Iberoamerican Conference on Supercritical Fluids (PROSCIBA 2023), AR.EXT
19/13496-0 - Multi user equipment approved in grant 2018/14582-5: ultra-high pressure liquid chromatography system (UHPLC), composed by a quaternary pump, autoinjector, oven with selection valve and detector (PDA), AP.EMU
Associated scholarship(s):23/03439-5 - Extraction, separation and two-dimensional analysis of phenolic compounds from agro-industry residues with antimicrobial potential against Staphylococcus aureus for application in curatives., BP.PD
23/12744-6 - EVALUATION OF THE THERMOSONICATION PROCESS FOR EXTRACTION OF CAFFEINE AND CHLOROGENIC ACID FROM COFFEE RESIDUE USING ALTERNATIVE SOLVENTS, BP.IC
23/11025-6 - Development of extraction methods, separation and two-dimensional analysis of phenolic compounds in natural products, BP.PD
+ associated scholarships 23/05097-4 - Development of extraction methods, separation and two-dimensional analysis of phenolic compounds in natural products, BP.PD
22/10469-5 - Application of in silico tools for the extraction of bioactive compounds from agro by-products by gas-expanded liquids and green switchable solvents, BP.PD
21/12264-9 - A techno-economic evaluation of emerging technologies and green solvents coupling to the two-dimensional system of extraction, separation and analysis to obtain phenolic compounds from waste of the coffee and plant-based beverages industry, BP.PD
21/13638-0 - Development of active packaging through the extraction of bioactive compounds from pomegranate peel (Punica granatum L.), BP.MS
20/15774-5 - Development of methods of extraction, separation and two-dimensional analysis of phenolic compounds in natural products, BP.PD
20/04067-6 - Evaluation of ultrasound-assisted pressurized fluid extraction coupled with solid phase extraction for extracting phenolic compounds and terpenes from rosemary (Rosmarinus officinalis) and sage (Salvia officinalis), BP.DD
20/08421-9 - Application of non-volatile alternative solvents to create sustainable two-dimensional and integrated platforms for harnessing agro-industrial waste from jaboticaba and pomegranate fruits, BP.PD
20/03623-2 - Extraction and separation of phenolic compounds from green propolis by a bidimensional system, BP.DD
19/24537-0 - Phytochemical evaluation of apple (Malus domestica) industrial residue from extraction and separation by a two-dimensional system, BP.DD - associated scholarships

Abstract

This research project proposes the development of a two-dimensional extraction, separation and analysis system (PLEgrad-SPE x UHPLC) by coupling extraction with gradient pressurized liquids (PLEgrad) with solid phase extraction (SPE) in the first dimension and orthogonally with ultra-high pressure chromatography (UHPLC) in the second dimension. The objective is to develop a system that allows the characterization of the chemical composition of natural raw materials in a fast, efficient and with real-time monitoring, while allowing the production of small quantities of extracts obtained through the fractionation of the present compounds. These fractions should be well characterized chemically and with low contamination between them. The system will be validated with several samples, including soybean (Glycine max), Brazilian ginseng (Pfaffia glomerata), black tea and green tea (Camellia sinensis), mate (Ilex paraguariensis), coffee (Coffea arabica), pomegranate granatum), orange peel (Citrus sinensis), sicilian lemon peel (Citrus x limon) apple peel (Malus domestica), jabuticaba bark (Myrciaria cauliflora), rosemary (Rosmarinus officinalis) and sage (Salvia officinalis). Initially the rapid UHPLC analysis methods will be developed that will be used in the second separation dimension. Several analysis conditions (temperature, column size, flow, volume and injection solvent and mobile phase composition) will be evaluated for an ultra-fast separation method (time between samples <2.0 min). Subsequently, different extraction conditions will be evaluated by SPE coupled gradient PLE, including temperature, pressure, sample amount, adsorbent type, flow, solvent and duration of the extraction / elution gradient. This proposal consists of a continuation of the Young Researcher project (FAPESP 2013 / 04304-4), seeking to consolidate this line of research at FCA / UNICAMP and to continue the training of qualified human resources. (AU)

Articles published in Pesquisa para Inovação FAPESP about research grant:
Novel technology produces natural colorants with enhanced stability from grape residue 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (37)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, CAMILA TELLES; DA SOUZA, MARIANA CORREA; DA FONSECA MACHADO, ANA PAULA; DO NASCIMENTO, ROBERTO DE PAULA; DA CUNHA, DIOGO THIMOTEO; NEVES BEZERRA, ROSANGELA MARIA; ROSTAGNO, MAURICIO ARIEL. Thermal stability and sensory evaluation of a bioactive extract from roasted coffee (Coffea arabica) beans added at increasing concentrations to conventional bread. JOURNAL OF FOOD PROCESSING AND PRESERVATION, v. 45, n. 11, . (18/14582-5, 16/19930-6, 17/23657-6, 13/04304-4, 18/17089-8)
CHAVES, JAISA O.; SANCHES, VITOR L.; VIGANO, JULIANE; MESQUITA, LEONARDO M. DE SOUZA; DE SOUZA, MARIANA C.; DA SILVA, LAISE C.; ACUNHA, TANIZE; FACCIOLI, LUCIA H.; ROSTAGNO, MAURICIO A.. Integration of pressurized liquid extraction and in-line solid-phase extraction to simultaneously extract and concentrate phenolic compounds from lemon peel (Citrus limon L.). Food Research International, v. 157, p. 12-pg., . (13/04304-4, 20/08421-9, 15/00658-1, 19/13496-0, 18/14582-5, 20/15774-5)
MACIEL-SILVA, FRANCISCO W.; BULLER, LUZ S.; GONCALVES, MARIA L. M. B. B.; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. ustainable development in the Legal Amazon: energy recovery from acai seed. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. 15, n. 4, p. 1174-1189, . (18/14582-5, 18/14938-4, 20/10323-5, 18/05999-0)
BAIAO DIAS, ARTHUR LUIZ; DE AGUIAR, ANA CAROLINA; ROSTAGNO, MAURICIO A.. Extraction of natural products using supercritical fluids and pressurized liquids assisted by ultrasound: Current status and trends. ULTRASONICS SONOCHEMISTRY, v. 74, . (18/14582-5)
DA SILVA, LAISE C.; SOUZA, MARIANA C.; SUMERE, BEATRIZ R.; SILVA, LUIZ G. S.; DA CUNHA, DIOGO T.; BARBERO, GERARDO F.; BEZERRA, ROSANGELA M. N.; ROSTAGNO, MAURICIO A.. Simultaneous extraction and separation of bioactive compounds from apple pomace using pressurized liquids coupled on-line with solid-phase extraction. Food Chemistry, v. 318, . (18/14582-5, 16/19930-6, 18/17089-8, 19/24537-0)
BARROSO, TIAGO; SGANZERLA, WILLIAM; ROSA, RAFAEL; CASTRO, LUIZ; MACIEL-SILVA, FRANCISCO; ROSTAGNO, MAURICIO; FORSTER-CARNEIRO, TANIA. Semi-continuous flow-through hydrothermal pretreatment for the recovery of bioproducts from jabuticaba (Myrciaria cauliflora) agro-industrial by-product. Food Research International, v. 158, p. 12-pg., . (20/16248-5, 18/14582-5, 21/04096-9, 19/26925-7)
MACIEL-SILVA, FRANCISCO W.; VIGANO, JULIANE; CASTRO, LUIZ E. N.; SGANZERLA, WILLIAM GUSTAVO; BULLER, LUZ SELENE; MARTINEZ, JULIAN; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Pressurized liquid extraction coupled in-line with SPE and on-line with HPLC (PLE-SPExHPLC) for the recovery and purification of anthocyanins from SC-CO2 semi-defatted Acai (Euterpe oleracea). Food Research International, v. 160, p. 11-pg., . (20/10323-5, 20/15774-5, 18/14938-4, 18/05999-0, 19/26925-7, 18/14582-5)
TORRES-MAYANGA, PAULO. C. C.; CASTRO, LUIZ E. N.; AZAMBUJA, SUELLEN P. H.; LACHOS-PEREZ, DANIEL; BROWN, AVERY. B. B.; TIMKO, MICHAEL. T. T.; GOLDBECK, ROSANA; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO. A. A.. Detoxification of furanic aldehydes of the hemicellulosic hydrothermal hydrolysate of brewers' spent grains by continuous adsorption on a fixed-bed column. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. N/A, p. 14-pg., . (21/04096-9, 20/10323-5, 18/14938-4, 18/05999-0, 18/14582-5)
LACHOS-PEREZ, DANIEL; BASEGGIO, ANDRESSA M.; TORRES-MAYANGA, PAULO C.; AVILA, PATRICIA F.; TOMPSETT, G. A.; MAROSTICA, MARIO; GOLDBECK, ROSANA; TIMKO, MICHAEL T.; ROSTAGNO, MAURICIO; MARTINEZ, JULIAN; et al. Sequential subcritical water process applied to orange peel for the recovery flavanones and sugars. JOURNAL OF SUPERCRITICAL FLUIDS, v. 160, . (18/14582-5, 18/05999-0, 11/19817-1, 16/04602-3)
CONTIERI, LETICIA S.; MESQUITA, LEONARDO M. DE SOUZA; SANCHES, VITOR L.; VIGANO, JULIANE; KAMIKAWACHI, RENAN CANUTE; VILEGAS, WAGNER; ROSTAGNO, MAURICIO A.. Ultra-high-performance liquid chromatography using a fused-core particle column for fast analysis of propolis phenolic compounds. JOURNAL OF SEPARATION SCIENCE, v. 46, n. 3, p. 12-pg., . (18/14582-5, 19/13496-0, 20/08421-9, 20/15774-5)
MESQUITA, LEONARDO M. DE SOUZA; CONTIERI, LETICIA S.; SANCHES, VITOR L.; KAMIKAWACHI, RENAN; SOSA, FILIPE H. B.; VILEGAS, WAGNER; ROSTAGNO, MAURICIO A.. Fast and green universal method to analyze and quantify anthocyanins in natural products by UPLC-PDA. Food Chemistry, v. 428, p. 11-pg., . (21/11022-1, 18/14582-5, 20/08421-9, 19/13496-0, 20/03623-2, 21/11023-8)
SANCHES, VITOR L.; DE SOUZA MESQUITA, LEONARDO M.; VIGANO, JULIANE; CONTIERI, LETICIA S.; PIZANI, RODRIGO; CHAVES, JAISA; DA SILVA, LAISE CAPELASSO; DE SOUZA, MARIANA CORREA; BREITKREITZ, MARCIA CRISTINA; ROSTAGNO, MAURICIO A.. Insights on the Extraction and Analysis of Phenolic Compounds from Citrus Fruits: Green Perspectives and Current Status. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, v. N/A, p. 27-pg., . (18/14582-5, 20/15774-5, 19/13496-0, 19/24537-0, 20/08421-9, 20/03623-2)
CHAVES, JAISA OLIVEIRA; DE SOUZA, MARIANA CORREA; DA SILVA, LAISE CAPELASSO; LACHOS-PEREZ, DANIEL; TORRES-MAYANGA, PAULO CESAR; MACHADO, ANA PAULA DA FONSECA; FORSTER-CARNEIRO, TANIA; VAZQUEZ-ESPINOSA, MERCEDES; GONZALEZ-DE-PEREDO, ANA VELASCO; BARBERO, GERARDO FERNANDEZ; et al. Extraction of Flavonoids From Natural Sources Using Modern Techniques. RONTIERS IN CHEMISTR, v. 8, p. 25-pg., . (18/17089-8, 18/05999-0, 18/14582-5, 16/19930-6, 18/14938-4)
VIGANO, JULIANE; STRIEDER, MONIQUE MARTINS; PIZANI, RODRIGO S.; CONTIERI, LETICIA S.; MESQUITA, LEONARDO M. DE SOUZA; ROSTAGNO, MAURICIO A.. Application of an integrative system (2D PLExHPLC-PDA) for bioactive compound extraction and online quantification: Advantages, validation, and considerations. Analytica Chimica Acta, v. 1272, p. 9-pg., . (18/14582-5, 20/08421-9, 20/15774-5, 19/13496-0, 21/12264-9, 20/03623-2, 20/04067-6)
BARROSO, TIAGO LINHARES CRUZ TABOSA; SGANZERLA, WILLIAM GUSTAVO; CASTRO, LUIZ EDUARDO NOCHI; FREIRIA, NICOLAS LUIS MOREIRA; BARBERO, GERARDO FERNANDEZ; LOVILLO, MIGUEL PALMA; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Removal of 5-hydroxymethylfurfural from brewer's spent grains hydrolysates obtained by subcritical water hydrolysis: An approach using liquid-liquid extraction. JOURNAL OF SUPERCRITICAL FLUIDS, v. 201, p. 9-pg., . (21/04096-9, 18/14582-5, 18/14938-4, 20/16248-5, 19/26925-7)
DE SOUZA MESQUITA, LEONARDO M.; CONTIERI, LETICIA S.; SOSA, FILIPE H. B.; PIZANI, RODRIGO S.; CHAVES, JAISA; VIGANO, JULIANE; VENTURA, SONIA P. M.; ROSTAGNO, MAURICIO A.. Combining eutectic solvents and pressurized liquid extraction coupled in-line with solid-phase extraction to recover, purify and stabilize anthocyanins from Brazilian berry waste. GREEN CHEMISTRY, v. 25, n. 5, p. 14-pg., . (21/11022-1, 18/14582-5, 20/08421-9, 20/15774-5, 19/13496-0, 20/03623-2, 21/11023-8, 20/04067-6)
COSTA, JOSIEL MARTINS; STRIEDER, MONIQUE MARTINS; SALDANA, MARLENY D. A.; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Recent Advances in the Processing of Agri-food By-products by Subcritical Water. Food and Bioprocess Technology, v. N/A, p. 20-pg., . (18/14582-5, 18/14938-4, 21/12264-9, 21/03950-6)
NOCHI CASTRO, LUIZ EDUARDO; SGANZERLA, WILLIAM GUSTAVO; CRUZ TABOSA BARROSOA, TIAGO LINHARES; MACIEL-SILVA, FRANCISCO WESHLEY; SARAGIOTTO COLPINI, LEDA MARIA; STIVAL BITTENCOURT, PAULO RODRIGO; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Improving the semi-continuous flow-through subcritical water hydrolysis of grape pomace (Vitis vinifera L.) by pH and temperature control. JOURNAL OF SUPERCRITICAL FLUIDS, v. 196, p. 14-pg., . (21/04096-9, 18/14582-5, 18/14938-4, 19/26925-7, 20/16248-5)
OLIVEIRA, T. C. G.; INTERLANDI, M. A.; HANLON, K. E.; TORRES-MAYANGA, P. C.; SILVELLO, M. A. C.; TIMKO, M. T.; ROSTAGNO, M. A.; GOLDBECK, R.; FORSTER-CARNEIRO, T.. Integration of Subcritical Water and Enzymatic Hydrolysis to Obtain Fermentable Sugars and Second-Generation Ethanol from Sugarcane Straw. BioEnergy Research, v. 15, n. 2, p. 12-pg., . (19/08542-3, 18/05999-0, 18/14582-5, 13/04304-4, 18/14938-4)
SANTANA, IGOR M.; ROSTAGNO, MAURICIO A.; BREITKREITZ, MARCIA C.. Analytical quality-by-design (AQbD) approach for comprehensive analysis of bioactive compounds from Citrus peel wastes by UPLC. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 415, n. 18, p. 12-pg., . (18/14582-5)
OLIVEIRA, T. C. G.; HANLON, K. E.; INTERLANDI, M. A.; TORRES-MAYANGA, P. C.; SILVELLO, M. A. C.; LACHOS-PEREZ, D.; TIMKO, M. T.; ROSTAGNO, M. A.; GOLDBECK, R.; FORSTER-CARNEIRO, T.. Subcritical water hydrolysis pretreatment of sugarcane bagasse to produce second generation ethanol. JOURNAL OF SUPERCRITICAL FLUIDS, v. 164, . (18/14582-5, 18/23835-4, 18/14938-4, 18/05999-0, 19/08542-3)
SOUZA, MARIANA C.; SILVA, LAISE C.; CHAVES, JAISA O.; SALVADOR, MAYARA P.; SANCHES, VITOR L.; DA CUNHA, DIOGO T.; CARNEIRO, TANIA FOSTER; ROSTAGNO, MAURICIO A.. Simultaneous extraction and separation of compounds from mate (Ilex paraguariensis) leaves by pressurized liquid extraction coupled with solid-phase extraction and in-line UV detection. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 2, p. 11-pg., . (19/24537-0, 18/14582-5, 13/04304-4, 16/19930-6)
VIGANO, JULIANE; SANCHES, VITOR L.; MESQUITA, LEONARDO M. DE SOUZA; DE SOUZA, MARIANA C.; DA SILVA, LAISE C.; CHAVES, JAISA O.; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO A.. Comprehensive analysis of phenolic compounds from natural products: Integrating sample preparation and analysis. Analytica Chimica Acta, v. 1178, . (19/24537-0, 18/14582-5, 19/18772-6, 20/08421-9, 18/17089-8, 13/04304-4, 18/14938-4, 20/15774-5)
BARROSO, TIAGO LINHARES CRUZ TABOSA; DA ROSA, RAFAEL GABRIEL; SGANZERLA, WILLIAM GUSTAVO; CASTRO, LUIZ EDUARDO NOCHI; MACIEL-SILVA, FRANCISCO WESHLEY; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Hydrothermal pretreatment based on semi-continuous flow-through sequential reactors for the recovery of bioproducts from jabuticaba (Myrciaria cauliflora) peel. JOURNAL OF SUPERCRITICAL FLUIDS, v. 191, p. 14-pg., . (18/14582-5, 19/26925-7, 20/16248-5, 21/04096-9)
DA SILVA, LAISE C.; VIGANO, JULIANE; SANCHES, VITOR L.; DE SOUZA MESQUITA, LEONARDO M.; PIZANI, RODRIGO; ROSTAGNO, MAURICIO A.. Simultaneous extraction and analysis of apple pomace by gradient pressurized liquid extraction coupled in-line with solid-phase extraction and on-line with HPLC. Food Chemistry, v. 407, p. 11-pg., . (18/14582-5, 19/13496-0, 19/24537-0, 20/04067-6, 20/15774-5)
DA SILVA, LAISE C.; VIGANO, JULIANE; DE SOUZA MESQUITA, LEONARDO M.; BAIAO DIAS, ARTHUR L.; DE SOUZA, MARIANA C.; SANCHES, VITOR L.; CHAVES, JAISA O.; PIZANI, RODRIGO S.; CONTIERI, LETICIA S.; ROSTAGNO, MAURICIO A.. Recent advances and trends in extraction techniques to recover polyphenols compounds from apple by-products. FOOD CHEMISTRY-X, v. 12, . (20/08421-9, 20/03623-2, 19/24537-0, 20/15774-5, 19/18772-6, 19/13496-0, 18/17089-8, 20/04067-6, 18/14582-5)
FERREIRA, VANESSA COSME; AMPESE, LARISSA CASTRO; SGANZERLA, WILLIAM GUSTAVO; COLPINI, LEDA MARIA SARAGIOTTO; FORSTER-CARNEIRO, TANIA. An updated review of recent applications and future perspectives on the sustainable valorization of pitaya (Hylocereus spp.) by- products. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 33, p. 18-pg., . (18/14582-5, 22/02305-2)
FERREIRA, VANESSA COSME; SGANZERLA, WILLIAM GUSTAVO; BARROSO, TIAGO LINHARES CRUZ TABOSA; CASTRO, LUIZ EDUARDO NOCHI; COLPINI, LEDA MARIA SARAGIOTTO; FORSTER-CARNEIRO, TANIA. Sustainable valorization of pitaya (Hylocereus spp.) peel in a semi-continuous high-pressure hydrothermal process to recover value-added products. Food Research International, v. 173, p. 12-pg., . (22/02305-2, 21/04096-9, 18/14582-5, 20/16248-5)
CONTIERI, LETICIAS.; RIBEIRO, TANIA B.; SOSA, FILIPE H. B.; VAZ, BARBARA M. C.; PIZANI, RODRIGO S.; PINTADO, MANUELA; VENTURA, SONIA P. M.; MESQUITA, LEONARDO M. DE SOUZA; ROSTAGNO, MAURICIO A.. Unlocking the Full Potential of Green Propolis: A Novel Extraction Approach Using Eutectic Solvents for Improved Phenolic Compound Recovery. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 11, n. 36, p. 13-pg., . (21/11022-1, 18/14582-5, 20/08421-9, 19/13496-0, 20/03623-2, 21/11023-8, 20/04067-6)
SANCHES, VITOR L.; CUNHA, TANIZE A.; VIGANO, JULIANE; DE SOUZA MESQUITA, LEONARDO M.; FACCIOLI, LUCIA HELENA; BREITKREITZ, MARCIA CRISTINA; ROSTAGNO, MAURICIO A.. Comprehensive analysis of phenolics compounds in citrus fruits peels by UPLC-PDA and UPLC-Q/TOF MS using a fused-core column. FOOD CHEMISTRY-X, v. 14, p. 9-pg., . (20/08421-9, 19/13496-0, 18/14582-5, 20/15774-5)
MACIEL-SILVA, FRANCISCO W.; LACHOS-PEREZ, DANIEL; BULLER, LUZ SELENE; SGANZERLA, WILLIAM G.; PEREZ, MONTSERRAT; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Green Extraction Processes for Complex Samples from Vegetable Matrices Coupled with On-Line Detection System: A Critical Review. Molecules, v. 27, n. 19, p. 21-pg., . (18/14582-5, 20/10323-5, 19/08542-3, 18/14938-4)
CONTIERI, LETICIA S.; DE SOUZA MESQUITA, LEONARDO M.; SANCHES, VITOR L.; VIGANO, JULIANE; MARTINEZ, JULIAN; DA CUNHA, DIOGO T.; ROSTAGNO, MAURICIO A.. Standardization proposal to quality control of propolis extracts commercialized in Brazil : A fingerprinting methodology using a UHPLC-PDA-MS/MS approach. Food Research International, v. 161, p. 11-pg., . (18/14582-5, 19/13496-0, 20/08421-9, 20/03623-2, 20/15774-5)
RIBEIRO, MAURICIO M. DE SOUZA; VIGANO, JULIANE; DE NOVAIS, NATHALIA STAHL; MESQUITA, LEONARDO M. DE SOUZA; KAMIKAWACHI, RENAN CANUTE; VILEGAS, WAGNER; LOPES, PATRICIA SANTOS; DA SILVA, CAMILA SOARES; ROSTAGNO, MAURICIO ARIEL; VEGGI, PRISCILA CARVALHO. The effect of ultrasound on improving the extraction of tannins from the Stryphnodendron adstringens bark. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 33, p. 14-pg., . (20/15774-5, 18/14582-5, 19/13496-0, 20/07575-2)
STRIEDER, MONIQUE MARTINS; PINAS, JEAN AGUSTIN VELASQUEZ; AMPESE, LARISSA CASTRO; COSTA, JOSIEL MARTINS; CARNEIRO, TANIA FORSTER; ROSTAGNO, MAURICIO ARIEL. Coffee biorefinery: The main trends associated with recovering valuable compounds from solid coffee residues. JOURNAL OF CLEANER PRODUCTION, v. 415, p. 16-pg., . (21/08696-0, 21/03950-6, 18/14582-5, 19/13496-0, 18/14938-4, 21/12264-9)
BARROSO, TIAGO L. C. T.; CASTRO, LUIZ E. N.; F. BARBERO, GERARDO; PALMA, MIGUEL; CARRERA, CEFERINO; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Optimization of a Microwave-Assisted Extraction Method for the Recovery of the Anthocyanins from Jabuticaba By-Products. AGRONOMY-BASEL, v. 13, n. 2, p. 13-pg., . (22/02039-0, 18/14938-4, 20/16248-5, 18/14582-5, 21/04096-9)
CONTIERI, LETICIA S.; MESQUITA, LEONARDO M. DE SOUZA; SANCHES, VITOR L.; CHAVES, JAISA; PIZANI, RODRIGO S.; DA SILVA, LAISE C.; VIGANO, JULIANE; VENTURA, SONIA P. M.; ROSTAGNO, MAURICIO A.. Recent progress on the recovery of bioactive compounds obtained from propolis as a natural resource: Processes, and applications. Separation and Purification Technology, v. 298, p. 18-pg., . (18/17089-8, 19/18772-6, 18/14582-5, 20/08421-9, 19/24537-0, 20/15774-5, 20/03623-2, 20/04067-6)
PIZANI, RODRIGO S.; VIGANO, JULIANE; DE SOUZA MESQUITA, LEONARDO M.; CONTIERI, LETICIA S.; SANCHES, VITOR L.; CHAVES, JAISA O.; SOUZA, MARIANA C.; DA SILVA, LAISE C.; ROSTAGNO, MAURICIO A.. Beyond aroma: A review on advanced extraction processes from rosemary (Rosmarinus officinalis) and sage (Salvia officinalis) to produce phenolic acids and diterpenes. TRENDS IN FOOD SCIENCE & TECHNOLOGY, v. 127, p. 18-pg., . (18/17089-8, 18/14582-5, 20/08421-9, 19/24537-0, 20/15774-5, 20/03623-2, 19/13496-0, 20/04067-6)

Please report errors in scientific publications list using this form.
Filed patent(s) as a result of this research project

SISTEMA BIDIMENSIONAL PARA A EXTRAÇÃO, PURIFICAÇÃO E ANÁLISE DE COMPOSTOS BIOATIVOS BR1020200172387 - Universidade Estadual de Campinas (UNICAMP) . Mauricio Ariel Rostagno ; Mariana Corrêa De Souza ; Laise Capelasso Da Silva ; Tania Forster Carneiro ; Francisco Weshley Maciel Silva ; Vitor Lacerda Sanches ; Jaísa Oliveira Chaves - August 2020, 24

PROCESSO DE SEPARAÇÃO DE COMPOSTOS PROVENIENTES DE MATRIZES VEGETAIS COM DETECÇÃO EM LINHA BR132021015169-1 - Universidade Estadual de Campinas (UNICAMP) . Tânia Forster Carneiro ; Mariana Corrêa De Souza ; Laise Capelasso Da Silva ; Vitor Lacerda Sanches ; Mauricio Ariel Rostagno ; Jaísa Oliveira Chaves ; Leonardo Mendes De Souza Mesquita - July 2021, 30