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Nanostructured interfaces for the investigation of bioactive substances in cell membrane models and for the construction of optoelectronic devices

Abstract

In this project, we intend to use structures organized at the molecular level at interfaces as cell membrane models, and for the immobilization of enzymes for the production of enzymatic optoelectronic devices. For that, we will use Langmuir monolayers and Langmuir-Blodgett (LB) films. The films will be produced from materials of pharmacological and / or technological interest, in which insoluble amphiphiles, such as lipids, forming a monolayer at the air-water interface, pure or mixed with proteins, and bioactive potential compounds such as those with antifungal, or antitumor activity, will interact with the interface and be investigated by means of tensiometric, electrical, rheological, spectroscopic and morphological measurements. It is also intended to immobilize enzymes, antibodies and moieties of nucleic acids in LB films for the production of optoelectronic devices capable of molecular recognition. As a result, substances that aid in the molecular accommodation, modulating the biological activity and the response signal of the interaction, will be employed. Candidates include conductive polymers, metal nanoparticles, polysaccharides, graphene, and carbon nanotubes. In this sense, the remarkable interaction that the proponent has with groups inside and outside the institution, specialists in the obtaining of bioactive materials of interest, in Molecular Biology, and in the synthesis of conducting polymers. This fact allows, therefore, to make up such specialties, investigating at the molecular level interactions that aid in the understanding of biophysical and biochemical processes in cell membranes and also assist in the construction of intelligent surfaces constructed from bioinspired interfaces organized at the molecular level for the manufacture of optoelectronic devices such as biosensors. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (33)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, RAFAEL LEONARDO C. G.; GONCALVES, KARINA DE OLIVEIRA; COURROL, LILIA CORONATO; CASELI, LUCIANO. Study of the interactions of gold nanoparticles functionalized with aminolevulinic acid in membrane models. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 205, . (19/03239-0, 18/00291-9, 17/23686-6, 18/22214-6)
ROSA, MATHEUS ELIAS; ALVES CONSERVA, GEANNE A.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Monolayer nanoarchitectonics at the air-water interface for molecular understanding of the interaction of isolinderanolide E with cholesterol. Thin Solid Films, v. 754, p. 7-pg., . (19/03239-0, 16/20633-6, 18/22214-6, 21/02789-7, 19/04407-4)
MACHADO, ANDRE CAMPOS; DA SILVA, TAMIRIS REISSA CIPRIANO; RAMINELLI, CRISTIANO; CASELI, LUCIANO. Unsaturation pattern of phosphatidylglycerols modulating the interaction of lysicamine with cells membrane models at the air-water interface. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 222, p. 10-pg., . (18/22214-6, 19/03239-0, 20/01183-5, 20/12530-8)
RODRIGUES, RAUL TORRES; SOUZA NORDI, CRISTIANA FREIRE; SIQUEIRA JUNIOR, JOSE ROBERTO; CASELI, LUCIANO. Effect of interfering agents for urease immobilized in Langmuir-Blodgett films of controlled molecular architecture. Thin Solid Films, v. 704, . (19/03239-0, 16/01867-6)
PIRES, GUILHERME HENRIQUE DA CRUZ RAMOS; FREIRE, VITOR TORRES; PEREIRA, RAFAEL GUIMARAES; DE SIQUEIRA, LEONARDO JOSE AMARAL; UMEHARA, ERIC; LAGO, JOAO HENRIQUE CHILARDI; CASELI, LUCIANO. Sakuranetin interacting with cell membranes models: Surface chemistry combined with molecular simulation. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 216, p. 8-pg., . (18/22214-6, 19/03239-0, 19/18125-0)
OLIVEIRA, OSVALDO N., JR.; CASELI, LUCIANO; ARIGA, KATSUHIKO. The Past and the Future of Langmuir and Langmuir-Blodgett Films. CHEMICAL REVIEWS, v. 122, n. 6, p. 55-pg., . (19/03239-0, 18/22214-6)
DE SOUZA FURTADO, FERNANDO AUGUSTO; CASELI, LUCIANO. Enzyme activity preservation for galactose oxidase immobilized in stearic acid Langmuir-Blodgett films. Thin Solid Films, v. 709, . (19/03239-0)
PAROLIN, GIOVANA A.; GONCALVES, GIULIA E. G.; COSTA-SILVA, THAIS A.; TEMPONE, ANDRE G.; CASELI, LUCIANO; LAGO, JOAO HENRIQUE G.; PERES, LAURA O.. Evaluation of the effects in cellular membrane models of antitrypanosomal poly-thymolformaldehyde (PTF) using Langmuir monolayers. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1863, n. 2, . (18/22214-6, 14/50869-6, 18/07885-1, 18/18180-9, 18/10279-6, 19/03239-0)
SAKAI, ANDREI; DE SOUSA MESQUITA, ANA PAULA; DE CASTRO LEVATTI, ERICA VALADARES; STRAUS, ANITA HILDA; NADER, HELENA B.; LOPES, CARLA CRISTINA; CASELI, LUCIANO. Interaction of Trastuzumab with biomembrane models at air-water interfaces mimicking cancer cell surfaces. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1861, n. 10, . (19/03239-0, 15/23446-0, 13/14262-7)
RODRIGUES, RAUL T.; JR., JOSE R. SIQUEIRA; CASELI, LUCIANO. Structural and viscoelastic properties of floating monolayers of a pectinolytic enzyme and their influence on the catalytic properties. Journal of Colloid and Interface Science, v. 589, p. 568-577, . (14/50869-6, 18/22214-6, 18/22091-1, 19/03239-0)
RODRIGUES ROLA POSSARLE, LUIZ HENRIQUE; SIQUEIRA JUNIOR, JOSE ROBERTO; CASELI, LUCIANO. Insertion of carbon nanotubes in Langmuir-Blodgett films of stearic acid and asparaginase enhancing the catalytic performance. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 192, . (19/03239-0)
JAROQUE, GUILHERME NUNEZ; SARTORELLI, PATRICIA; CASELI, LUCIANO. Peptidoglycans modulating the interaction of a bactericide compound with lipids at the air-water interface. Chemistry and Physics of Lipids, v. 237, . (19/03239-0, 18/22214-6)
DE JESUS, CLEBER GOMES; RODRIGUES, REBECA DA ROCHA; CASELI, LUCIANO; PERES, LAURA OLIVEIRA. Conducting polymers modulating the catalytic activity of urease in thin composite films. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 654, p. 7-pg., . (20/04427-2, 19/03239-0, 14/50869-6, 18/22214-6)
SCHMIDT, THAIS F.; CASELI, LUCIANO. Molecular organization of dengue fusion peptide in phospholipid monolayers revealed by tensiometry and vibrational spectroscopy. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 215, p. 8-pg., . (19/03239-0, 18/22214-6)
RODRIGUES, REBECA DA ROCHA; CASELI, LUCIANO; PERES, LAURA OLIVEIRA. Langmuir and Langmuir-Blodgett Films of Poly[(9,9-dioctylfluorene)-co-(3-hexylthiophene)] for Immobilization of Phytase: Possible Application as a Phytic Acid Sensor. Langmuir, v. 36, n. 35, p. 10587-10596, . (19/03239-0, 14/50869-6)
MACHADO, ANDRE CAMPOS; CASELI, LUCIANO. Ultrathin films to investigate the interaction of nitrofurantoin with phospholipids. Thin Solid Films, v. 725, . (18/25943-9, 19/03239-0, 18/22214-6)
JAROQUE, GUILHERME NUNEZ; SARTORELLI, PATRICIA; CASELI, LUCIANO. The effect of the monocyclic monoterpene tertiary alcohol gamma-terpineol on biointerfaces containing cholesterol. Chemistry and Physics of Lipids, v. 230, . (19/03239-0)
BARBOSA, HENRIQUE; DA SILVA, RAFAEL LEONARDO C. G.; COSTA-SILVA, THAIS A.; TEMPONE, ANDRE G.; ANTAR, GUILHERME M.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Interaction of dicentrinone, an antitrypanosomal aporphine alkaloid isolated from Ocotea puberula (Lauraceae), in cell membrane models at the air-water interface. BIOORGANIC CHEMISTRY, v. 101, . (18/00291-9, 18/10279-6, 19/03239-0, 18/07885-1)
RODRIGUES, RAUL TORRES; CASELI, LUCIANO. Interfacial properties of pectinase forming ultrathin films from a saline solution. Thin Solid Films, v. 753, p. 5-pg., . (18/22091-1, 14/50869-6, 19/03239-0, 18/22214-6)
ROSA, MATHEUS ELIAS; CONSERVA, GEANNE A. ALVES; PASSERO, LUIZ FELIPE D.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Unsaturated lipids modulating the interaction of the antileishmanial isolinderanolide E with models of cellular membranes. BIOORGANIC CHEMISTRY, v. 124, p. 7-pg., . (21/02789-7, 19/04407-4, 16/20633-6, 18/22214-6, 18/24077-6, 19/03239-0)
SCHOLL, FABIO A.; SIQUEIRA, JOSE R., JR.; CASELI, LUCIANO. Graphene Oxide Modulating the Bioelectronic Properties of Penicillinase Immobilized in Lipid Langmuir-Blodgett Films. Langmuir, v. 38, n. 7, p. 7-pg., . (19/03239-0, 18/22214-6)
ESCOBAR, BRUNO DE ANDRADE; VALERIO, GABRIEL LUNDGREN FERREIRA; CASELI, LUCIANO. Biological activity of pectic polysaccharides investigated through biomembrane models formed at the air-water interface. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 216, p. 6-pg., . (19/03239-0, 18/22214-6)
RODRIGUES, REBECA DA ROCHA; CRUZ GOMES DA SILVA, RAFAEL LEONARDO; CASELI, LUCIANO; PERES, LAURA OLIVEIRA. Conjugated polymers as Langmuir and Langmuir-Blodgett films: Challenges and applications in nanostructured devices. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 285, . (18/00291-9, 14/50869-6, 19/03239-0)
SAKAI, ANDREI; DE SOUSA MESQUISTA, ANA PAULA; NADER, HELENA B.; LOPES, CARLA CRISTINA; NAKANISHI, WAKA; ARIGA, KATSUHIKO; CASELI, LUCIANO. The lipid composition affects Trastuzumab adsorption at monolayers at the air-water interface. Chemistry and Physics of Lipids, v. 227, . (19/03239-0)
CRUZ GOMES DA SILVA, RAFAEL LEONARDO; SHARMA, SHIV K.; PAUDYAL, SURAJ; MINTZ, KEENAN J.; LEBLANC, ROGER M.; CASELI, LUCIANO. Surface Chemistry Studies on the Formation of Mixed Stearic Acid/Phenylalanine Dehydrogenase Langmuir and Langmuir-Blodgett Films. Langmuir, v. 37, n. 25, p. 7771-7779, . (19/01797-6, 18/22214-6, 18/00291-9, 19/03239-0)
ROSA, MATHEUS ELIAS; ALVES CONSERVA, GEANNE A.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. nteraction of isolinderanolide E obtained from Nectandra oppositifolia with biomembrane model. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1863, n. 10, . (19/03239-0, 16/20633-6, 18/22214-6, 19/04407-4)
DE SOUZA FURTADO, FERNANDO AUGUSTO; BERRIO ESCOBAR, JHON FERNANDO; MARTINEZ, ALEJANDRO MARTINEZ; GIORDANI, CRISTIANO; ALMEIDA CAIUT, JOSE MAURICIO; CASELI, LUCIANO; MOLINA, CELSO. Molecular Information on the Potential of Europium Complexes for Local Recognition of a Nucleoside-Based Drug by Using Nanostructured Interfaces Assembled as Langmuir-Blodgett Films. Langmuir, v. 36, n. 14, p. 3843-3852, . (19/03239-0)
GONCALVES, GIULIA ELISA G.; UMEHARA, ERIC; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Incorporation of dehydrodieugenol, a neolignan isolated from Nectandra leucantha (Lauraceae), in lipid Langmuir monolayers as biomembrane models. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1864, n. 11, p. 10-pg., . (19/03239-0, 21/02391-3, 21/02789-7)
GONCALVES, GIULIA ELISA G.; OLIVEIRA, SAMUEL; GOMES, KAIO DE SOUZA; COSTA-SILVA, THAIS ALVES; TEMPONE, ANDRE GUSTAVO; LAGO, JOAO HENRIQUE GHILARDI; CASELI, LUCIANO. Effect of partial O-methylation in dehydrodieugenol on its antitrypanosomal activity-correlation with the toxicity using cell membrane models. Biophysical Chemistry, v. 296, p. 11-pg., . (19/03239-0, 21/02789-7, 22/03736-7)
PIRES, GUILHERME HENRIQUE DA CRUZ RAMOS; BARBOSA, HENRIQUE; ALMEIDA, ROBERTO BAPTISTA PEREIRA; LAGO, JOAO HENRIQUE GHILARDI; CASELI, LUCIANO. Ethanolamine phospholipids at the air-water interface as cell membranes models of microorganisms to study the nanotoxicology of sakuranetin. Thin Solid Films, v. 770, p. 8-pg., . (19/03239-0, 19/18125-0, 18/22214-6, 21/02789-7, 22/03736-7)

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