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Nanoparticles associated with antibiotics for the treatment of bacteremia caused by resistant microorganisms

Grant number: 18/23898-6
Support Opportunities:Regular Research Grants
Duration: April 01, 2019 - January 31, 2022
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Maiara Lima Castilho
Grantee:Maiara Lima Castilho
Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Associated researchers:Leandro José Raniero ; Luciane Dias de Oliveira


Bloodstream infections (BSIs) are one of the major healthcare-related infections, which is a major public health challenge worldwide because of the high morbidity, mortality, and associated costs. One of the most common clinical conditions is bacteremia defined as the presence of viable bacteria in the bloodstream, caused by resistant microorganisms such as Staphylococcus aureus, Acinetobacter baumannii and Klebsiella pneumoniae. The conventional treatment for the eradication of viable bacteria in the bloodstream is made with antibiotics, which is dependent on the species and its sensitivity profile, however the treatment efficiency is limited due to the resistance acquired by the microorganisms. Morbidity and mortality rates related to BSIs by resistant phenotype microorganisms have become a worldwide health problem, and the need for the development of new alternative methods for the treatment of these bacteremias is evident. Nanotechnology adds new alternative forms for the treatment of diverse diseases, with greater efficiency, speed and cost-benefit. Silver nanoparticles (AgNPs) show potential biomedical applications, due to their antibacterial properties associated with the small propensity to induce microbial resistance, besides having low toxicity to human cells. The present project proposes the development of AgNPs associated with antibiotics as an alternative method for the treatment of viable bacteria in the bloodstream. Thus, AgNPs with the action of the antibiotic will be a system with double power of bacterial inhibition, aiming at decreasing the rate of mortality and morbidity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONTOURA, INGLID; VERIATO, THAIS S.; RANIERO, LEANDRO J.; CASTILHO, MAIARA L.. Analysis of Capped Silver Nanoparticles Combined with Imipenem against Different Susceptibility Profiles of Klebsiella pneumoniae. ANTIBIOTICS-BASEL, v. 12, n. 3, p. 15-pg., . (18/23898-6)
CAMARGO, LARISSA DE O.; FONTOURA, INGLID; VERIATO, THAIS S.; RANIERO, LEANDRO; CASTILHO, MAIARA L.. Antibacterial activity of silver nanoparticles functionalized with amikacin applied against multidrug-resistant acinetobacter baumannii. AMERICAN JOURNAL OF INFECTION CONTROL, v. 51, n. 8, p. 8-pg., . (18/23898-6)
VERIATO, THAIS S.; FONTOURA, INGLID; OLIVEIRA, LUCIANE D. D.; RANIERO, LEANDRO J. J.; CASTILHO, MAIARA L. L.. Nano-antibiotic based on silver nanoparticles functionalized to the vancomycin-cysteamine complex for treating Staphylococcus aureus and Enterococcus faecalis. PHARMACOLOGICAL REPORTS, v. 75, n. 4, p. 11-pg., . (18/23898-6)

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