Research Grants 18/22363-1 - Química médica, Inibidores de proteínas quinases - BV FAPESP
Advanced search
Start date
Betweenand

Macrocyclic compounds as strategy for kinase-related chemical probe development

Abstract

Recent advances have highlighted the advantages of using macrocyclic compounds as a basis for protein kinase inhibitors. However, the design and synthesis methodologies for such macrocyclic inhibitors are at an early stage. SGC-Unicamp works on inhibitor development for several protein kinases which are good candidates for development of macrocyclic inhibitors. Those candidate kinases can bind inhibitors with small hinge-binding groups and sometimes, can also accommodate ligands in a teardrop binding mode. Additionally, new macrocyclic compounds can be screened against the SGC-Unicamp in-house panel of 40+ human protein kinases to identify new opportunities for inhibitor development. Whenever possible, SGC-Unicamp will perform co-crystallization trials and solve co-crystal structures for the target proteins in complex with the macrocyclic inhibitors. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.
X

Report errors in this page


Error details: