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Investigating the Pathogenesis and Drug Resistance in Microorganisms - Characterization and Control of ATP-Binding Cassette Transporters

Grant number: 18/20162-9
Support Opportunities:Regular Research Grants
Duration: February 01, 2019 - April 30, 2021
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Andrea Balan Fernandes
Grantee:Andrea Balan Fernandes
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

ABC transporters present great medical and pharmaceutical relevance since they are related to the development of the phenomenon of multiple drug resistance (MDR) in the treatment of cancer, bacterial resistance, infectivity and pathogenesis. Although extensively studied in many organisms, there are few functional or structural studies on these transporters in Mycobacterium tuberculosis and Xanthomonas citri pv. citri, two pathogenic bacteria studied by our group. In this project, different approaches will be developed to determine the function of these proteins in the mechanisms of pathogenesis and bacterial resistance, structural studies to understand mechanisms of interaction and ways of inhibiting the transporters. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MUNIZ, GABRIEL S. VIGNOLI; SOUZA, MARIANA C.; DUARTE, EVANDRO L.; LAMY, M. TERESA. Comparing the interaction of the antibiotic levofloxacin with zwitterionic and anionic membranes: Calorimetry, fluorescence, and spin label studies. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1863, n. 7, p. 16-pg., . (18/20162-9, 17/25930-1, 14/50983-3)
MARQUEZIN, CASSIA A.; TERESA LAMY, M.; DE SOUZA, EDUARDO S.. Molecular collisions or resonance energy transfer in lipid vesicles? A methodology to tackle this question. JOURNAL OF MOLECULAR LIQUIDS, v. 341, . (21/01593-1, 18/20162-9, 14/50983-3, 17/25930-1)
VIGNOLI MUNIZ, GABRIEL S.; DE LA TORRE, I, LILIA; DUARTE, EVANDRO L.; LORENZON, ESTEBAN N.; CILLI, EDUARDO M.; BALAN, ANDREA; TERESA LAMY, M.. Interaction of synthetic antimicrobial peptides of the Hylin a1 family with models of eukaryotic structures: Zwitterionic membranes and DNA. BIOCHEMISTRY AND BIOPHYSICS REPORTS, v. 24, . (18/20162-9, 17/25930-1, 14/50983-3)
MATOS, FERNANDA LIMA; DUARTE, EVANDRO L.; MUNIZ, GABRIEL S. V.; MILAN-GARCES, ERIX ALEXANDER; COUTINHO, KALINE; LAMY, M. TERESA; DA CUNHA, ANTONIO R.. Spectroscopic characterization of different protonation/deprotonation states of Barbaloin in aqueous solution. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 286, p. 11-pg., . (17/25930-1, 14/50983-3, 18/20162-9, 21/01593-1, 17/03910-9, 21/09016-3)
DE LA TORRE, I, LILIA; VERGARA MEZA, JOSE G.; CABARCA, SINDY; COSTA-MARTINS, ANDRE G.; BALAN, ANDREA. Comparison of carbohydrate ABC importers from Mycobacterium tuberculosis. BMC Genomics, v. 22, n. 1, . (18/20162-9)
CABARCA, SINDY; DE SOUZA, MAXIMILIA FRAZAO; DE OLIVEIRA, ANDREW ALBERT; VIGNOLI MUNIZ, GABRIEL S.; LAMY, M. TERESA; DOS REIS, CAIO VINICIUS; TAKARADA, JESSICA; EFFER, BRIAN; SOUZA, LUCAS SANTOS; DE LA TORRE, LILIA IRIARTE; et al. Structure of the Mycobacterium tuberculosis cPknF and conformational changes induced in forkhead-associated regulatory domains. CURRENT RESEARCH IN STRUCTURAL BIOLOGY, v. 3, p. 165-178, . (18/20162-9)
FRANCO, LEANDRO R. R.; FONSECA, TERTIUS L. L.; COUTINHO, KALINE; GEORG, HERBERT C. C.. Elucidating the conformational change and electronic absorption spectrum of p-dimethylamino-cinnamaldehyde merocyanine across different solvent polarities. Journal of Chemical Physics, v. 159, n. 7, p. 14-pg., . (21/09016-3, 18/20162-9, 14/50983-3)
MUNIZ, GABRIEL S. VIGNOLI; DUARTE, EVANDRO L.; LORENZON, ESTEBAN N.; CILLI, EDUARDO M.; LAMY, M. TERESA. What different physical techniques can disclose about disruptions on membrane structure caused by the antimicrobial peptide Hylin a1 and a more positively charged analogue. Chemistry and Physics of Lipids, v. 243, p. 16-pg., . (17/25930-1, 18/20162-9, 14/50983-3, 21/01593-1)
MUNIZ, GABRIEL S. VIGNOLI; SOUZA, MARIANA C.; DUARTE, EVANDRO L.; LAMY, M. TERESA. omparing the interaction of the antibiotic levofloxacin with zwitterionic and anionic membranes: Calorimetry, fluorescence, and spin label studie. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1863, n. 7, . (18/20162-9, 17/25930-1, 14/50983-3)
DE CASTRO-AMARANTE, MARIA FERNANDA; PEREIRA, SAMUEL SANTOS; PEREIRA, LENNON RAMOS; SANTOS, LUCAS SOUZA; VENCESLAU-CARVALHO, ALEXIA ADRIANNE; MARTINS, EDUARDO GIMENES; BALAN, ANDREA; FERREIRA, LUIS CARLOS DE SOUZA. The Anti-Dengue Virus Peptide DV2 Inhibits Zika Virus Both In Vitro and In Vivo. Viruses-Basel, v. 15, n. 4, p. 11-pg., . (18/20162-9, 16/20045-7, 22/01034-5, 18/14459-9, 16/05570-8)

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