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A Phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current stimulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning

Grant number: 18/10861-7
Support Opportunities:Regular Research Grants
Duration: February 01, 2019 - July 31, 2022
Field of knowledge:Health Sciences - Medicine - Psychiatry
Convênio/Acordo: Research Foundation - Flanders (FWO)
Principal Investigator:Andre Russowsky Brunoni
Grantee:Andre Russowsky Brunoni
Principal researcher abroad: Marie-Anne Vanderhasselt
Institution abroad: Ghent University (UGent), Belgium
Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated scholarship(s):21/03474-0 - A phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current simulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning, BP.TT
21/00564-8 - A phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current simulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning, BP.TT
20/02356-0 - A phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current simulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning, BP.TT
+ associated scholarships 19/25558-0 - A phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current stimulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex, BP.TT
19/20706-1 - A phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current stimulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning, BP.TT
19/16468-8 - A phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current stimulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning, BP.TT
19/11555-0 - A phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current stimulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning, BP.TT - associated scholarships

Abstract

Non-invasive brain stimulation approaches have been increasingly used to target the prefrontal cortex and to induce activity changes in brain networks. New protocols within the field of neurostimulation suggest a combination of distinct non-invasive brain stimulation techniques that are based on different approaches to maximize required changes in brain activity. However - as the effects from these new protocols derive from studies stimulating the motor cortex - there is insufficient knowledge regarding the biology involved in the combination of different non-invasive brain stimulation targeting the pré-frontal cortex. This is nevertheless crucial to optimize the activity changes in neural areas that are know to play a crucial role in patients that are suffering from a mood disorder.This project consists on two large phase-I, well-controlled studies - to be performed at University of São Paulo (Brazil) and Ghent University (Belgium) - that will investigate brain activity following the proposed innovative non-invasive brain stimulation protocol (application, alone and combined, of anodal transcranial direct current stimulation and theta-burst stimulation). Our findings will not only deep our fundamental understanding of the biology involved in non-invasive brain stimulation of the pré-frontal cortex, but also contribute to the design of further studies in healthy volunteers and therapeutic protocols in patients. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Brazilian science attracting attention worldwide 
La ciencia brasileña que se ve en el mundo 
Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIEGO FREITAS TAVARES; PAULO SUEN; DORIS HUPFELD MORENO; EDUARD VIETA; RICARDO ALBERTO MORENO; ANDRÉ R. BRUNONI. Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression. Revista Brasileira de Psiquiatria, . (18/10861-7, 19/06009-6)
RAZZA, LAIS B.; DE SMET, STEFANIE; MOFFA, ADRIANO; SUDBRACK-OLIVEIRA, PEDRO; VANDERHASSELT, MARIE-ANNE; BRUNONI, ANDRE R.. Follow-up effects of transcranial direct current stimulation (tDCS) for the major depressive episode: A systematic review and meta-analysis. PSYCHIATRY RESEARCH, v. 302, . (19/06009-6, 19/10760-9, 19/07256-7, 18/10861-7)
RAZZA, LAIS B.; BUCHPIGUEL, CARLOS A.; DE SMET, STEFANIE; KLEIN, IZIO; BAEKEN, CHRIS; GALHARDONI, RICARDO; VANDERHASSELT, MARIE-ANNE; BRUNONI, ANDRE R.. Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex: study protocol of a randomized, double-blinded, sham-controlled trial using Tc-99m-ECD SPECT. Trends in Psychiatry and Psychotherapy, v. 43, n. 4, p. 293-301, . (19/07256-7, 18/10861-7)
VALIENGO, LEANDRO; MAIA, ANA; COTOVIO, GONCALO; GORDON, PEDRO C.; BRUNONI, ANDRE R.; FORLENZA, ORESTES, V; OLIVEIRA-MAIA, ALBINO J.. Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder in Older Adults: Systematic Review and Meta-analysis. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 77, n. 4, p. 10-pg., . (19/06009-6, 14/50873-3, 18/10861-7, 16/01302-9)
FELIPE DA SILVA, RENATA DE MELO; BRUNONI, ANDRE R.; GOERIGK, STEPHAN; BATISTUZZO, MARCELO CAMARGO; DA CONCEICAO COSTA, DANIEL LUCAS; DINIZ, JULIANA BELO; PADBERG, FRANK; D'URSO, GIORDANO; MIGUEL, EURIPEDES CONSTANTINO; SHAVITT, ROSELI GEDANKE. Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial. NEUROPSYCHOPHARMACOLOGY, v. 46, n. 5, . (11/21357-9, 14/50873-3, 18/10861-7)
LAÍS B. RAZZA; CARLOS A. BUCHPIGUEL; STEFANIE DE SMET; IZIO KLEIN; CHRIS BAEKEN; RICARDO GALHARDONI; MARIE-ANNE VANDERHASSELT; ANDRÉ R. BRUNONI. Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex: study protocol of a randomized, double-blinded, sham-controlled trial using 99mTc-ECD SPECT. Trends in Psychiatry and Psychotherapy, v. 43, n. 4, p. 293-301, . (18/10861-7, 19/07256-7)
ELTON DINIZ; LAIS FONSECA; DEYVIS ROCHA; ALISSON TREVIZOL; RAPHAEL CERQUEIRA; BRUNO ORTIZ; ANDRÉ R. BRUNONI; RODRIGO BRESSAN; CHRISTOPH U. CORRELL; ARY GADELHA. Treatment resistance in schizophrenia: a meta-analysis of prevalence and correlates. Revista Brasileira de Psiquiatria, v. 45, n. 5, p. 448-458, . (11/50740-5, 19/06009-6, 18/10861-7)
BORRIONE, LUCAS; KLEIN, IZIO; RAZZA, LAIS B.; SUEN, PAULO; BRUNONI, ANDRE R.. Use of app-based psychological interventions in combination with home-use transcranial direct current stimulation for the treatment of major depressive disorder: A case series. Journal of Affective Disorders, v. 288, p. 189-190, . (18/10861-7, 19/06009-6)
BERTO, LAURA F.; SUEMOTO, CLAUDIA K.; MORENO, ARLINDA B.; FONSECA, MARIA DE JESUS M.; NUNES, MARIA ANGELICA A.; MOLINA, MARIA DEL CARMEN B.; BARRETO, SANDHI M.; DINIZ, MARIA DE FATIMA HAUEISEN SANDER; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; et al. Increased Prevalence of Depression and Anxiety Among Subjects With Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY, v. 63, n. 6, p. 10-pg., . (20/06887-0, 19/06009-6, 18/10861-7)
GOERIGK, STEPHAN; CRETAZ, ERIC; SAMPAIO-JUNIOR, BERNARDO; MARCIANO VIEIRA, ERICA LEANDRO; GATTAZ, WAGNER; KLEIN, IZIO; LAFER, BENY; TEIXEIRA, ANTONIO LUCIO; CARVALHO, ANDRE F.; LOTUFO, PAULO A.; et al. Effects of tDCS on neuroplasticity and inflammatory biomarkers in bipolar depression: Results from a sham-controlled study. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 105, . (18/10861-7)
RAZZA, LAIS BORALLI; RODRIGUES DA SILVA, PEDRO HENRIQUE; BUSATTO, GERALDO F.; DE SOUZA DURAN, FABIO LUIS; PEREIRA, JULIANA; DE SMET, STEFANIE; KLEIN, IZIO; ZANAO, TAMIRES A.; LUETHI, MATTHIAS S.; BAEKEN, CHRIS; et al. Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex. BIOMEDICINES, v. 10, n. 10, p. 11-pg., . (18/10861-7, 19/07256-7)
ROSSON, STELLA; DE FILIPPIS, RENATO; CROATTO, GIOVANNI; COLLANTONI, ENRICO; PALLOTTINO, SIMONE; GUINART, DANIEL; BRUNONI, ANDRE R.; DELL'OSSO, BERNARDO; PIGATO, GIORGIO; HYDE, JOSHUA; et al. Brain stimulation and other biological non-pharmacological interventions in mental disorders: An umbrella review. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 139, p. 18-pg., . (19/06009-6, 18/10861-7)
WU, MING-KUNG; SATOGAMI, KAZUMI; LIANG, CHIH-SUNG; STUBBS, BRENDON; CARVALHO, ANDRE F.; BRUNONI, ANDRE R.; SU, KUAN-PIN; TU, YU-KANG; WU, YI-CHENG; CHEN, TIEN-YU; et al. Multiple comparison of different noninvasive brain stimulation and pharmacologic interventions in patients with methamphetamine use disorders: A network meta-analysis of randomized controlled trials. PSYCHIATRY AND CLINICAL NEUROSCIENCES, v. 76, n. 12, p. 11-pg., . (19/06009-6, 18/10861-7)
RAZZA, LAIS B.; LUETHI, MATTHIAS S.; ZANAO, TAMIRES; DE SMET, STEFANIE; BUCHPIGUEL, CARLOS; BUSATTO, GERALDO; PEREIRA, JULIANA; KLEIN, IZIO; KAPPEN, MITCHEL; MORENO, MARINA; et al. Transcranial direct current stimulation versus intermittent theta-burst stimulation for the improvement of working memory performance. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY, v. 23, n. 1, p. 8-pg., . (18/10861-7, 19/07256-7, 19/06009-6)
TAVARES, DIEGO FREITAS; SUEN, PAULO; MORENO, DORIS HUPFELD; VIETA, EDUARD; MORENO, RICARDO ALBERTO; BRUNONI, ANDRE R.. Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression. Revista Brasileira de Psiquiatria, v. 44, n. 6, p. 8-pg., . (17/19237-1, 18/10861-7, 19/06009-6)

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