Strategies to study pulmonary inflammation during comorbidities

Abstract

Comorbidities are one of the factors related to the development of more severe forms of asthma and tuberculosis. Both diseases are immuno-mediated (immunopathologies), characterized by exacerbation of pulmonary inflammation, but triggered by different effector mechanisms. The Subprojects contained in this proposal have a clear objective: to determine mechanisms that exacerbate pulmonary inflammation, aiming at the identification of molecules or cells that may represent the search for immunological targets for the development of innovative therapies for the most severe forms of asthma and tuberculosis. For this we will use experimental models asthma and pneumonia caused by pneumococcus, obesity and tuberculosis, diabetes and tuberculosis, which are comorbidities associated with the immunopathology of both diseases. To complement and validate preclinical studies, trials with samples of patients with asthma or tuberculosis are also covered in this proposal. The second clearly defined objective is the training of human resources and the development of quality research with translational potential. In this way we seek the intellectual, ethical, scientific and critical training to obtain innovative and consistent results that can positively affect the diffusion of Brazilian science to the world. (AU)