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Lifestyle, biochemical and genetic markers as cardiometabolic risk factors: Health Survey in São Paulo City

Grant number: 17/05125-7
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2019 - January 31, 2025
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal Investigator:Regina Mara Fisberg
Grantee:Regina Mara Fisberg
Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Flávia Mori Sarti ; Marcelo Macedo Rogero
Associated researchers: Adèle Helena Ribeiro ; Alex Antonio Florindo ; Andressa Cerqueira ; Bárbara Santarosa Emo Peters ; Billie Giles-Corti ; Chester Luiz Galvão Cesar ; Cristiane Hermes Sales ; Elizabeth Aparecida Ferraz da Silva Torres ; Ioná Zalcman Zimberg ; Josiemer Mattei ; Júlia Maria Pavan Soler ; Lígia Araújo Martini ; Ligia Vizeu Barrozo ; Maria Cecilia Goi Porto Alves ; Marilisa Berti de Azevedo Barros ; Michelle Alessandra de Castro ; Moisés Goldbaum ; Nágila Raquel Teixeira Damasceno ; Philip Charles Calder ; Regina Célia Mingroni Netto ; Sandra Maria Lima Ribeiro
Associated grant(s):24/03939-0 - 92nd European Atherosclerosis Society Congress, AR.EXT
Associated scholarship(s):22/11919-4 - Analysis of factors associated with health care utilization and costs in the context of the Andersen model: a population-based study, BP.DD
23/03023-3 - Association between polygenic risk score and zinc status of adolescents, adults, and elderly individuals with insulin resistance: a gene-nutrient analysis in a population-based study, BP.PD
23/04689-5 - Polygenic risk score related to energy intake regulation and association with body weight, waist circumference, and diet quality of adolescents, adults, and elderly in the city of Sao Paulo: a population-based study HS-SP, BP.PD
+ associated scholarships 22/14601-5 - Vitamin E and cardiometabolic risk in São Paulo city residents: dietary intake and plasma concentrations considering polymorphisms in SCARB1, CYP4F2, NKAIN3 and BUD13/ZNF259/APOA5 genes., BP.DR
22/03420-0 - Learning causal graphical models for obesity and other nutrition-related disorders, BP.IC
20/15899-2 - Association between dyslipidemias and health costs at population level: Polygenic risk scores and modeling through computational microsimulation., BP.DR
21/05327-4 - Analysis of factors associated with utilization and costs of health care in the context of Andersen's model: population-based study in the municipality of Sao Paulo, 2003-2015, BP.MS
20/06110-6 - Grain foods with d10:1 carbohydrate-to-fiber ratio in the population of São Paulo: analysis of effects of changes in diet on cardiometabolic risk factors, BP.PD
20/07749-0 - Diet quality and genetic factors associated with Hypertension in residents of the city of São Paulo, BP.DR
20/09451-9 - Fat consumption and cardiometabolic risk in residents of the city of São Paulo: dietary intake and cardioprotective potential considering polymorphisms in the FADS1 and FADS2 genes, BP.DR
20/03104-5 - Plasma microRNA expression and its relationship with inflammatory biomarkers, nutritional status and dietary pattern in elderly people participating in a population-based study (ISA capital), BP.DR
19/23985-9 - Investigation of molecular bases of multifactorial chronic diseases in the population of São Paulo by GWAS, BP.PD
19/22934-1 - Association between circulating microRNA, cardiometabolic biomarkers and diet in adult individuals participants of a population-based study - ISA-Capital, BP.DR
19/05685-8 - Iron and cardiometabolic risk factors in individuals living in the city of São Paulo: investigating the associations of the genetic susceptibility to type 2 diabetes, obesity and cardiovascular diseases, BP.PD - associated scholarships


In view of the expressive prevalence of non-communicable chronic diseases (NCD), such as cardiovascular diseases, and negative repercussions on health and economy, strategies that investigate cardiometabolic risk factors are crucial for prevention and control of NCD. In this context, this population-based cross-sectional study aims to evaluate lifestyle-related modifiable factors in residents of the city of São Paulo, as well as its association with biochemical and genetic markers related to cardiometabolic risk factors. For this purpose, socio-demographic, economic and lifestyle data were collected in a structured questionnaire from individuals of both sexes, aged 12 years and older (n = 901). During the second visit, anthropometric evaluation, blood pressure measurement and blood collection were performed, and the adults and older adults were invited to perform bone densitometry and estimate energy expenditure by doubly labeled water. Blood was collected for determination of micronutrient concentration, glycaemia, lipid profile, inflammation biomarkers and single nucleotide polymorphisms. Food consumption was assessed by two 24-hour recalls. As NCD present multifactorial etiology, an approach that considers cardiometabolic risk markers (inflammation, lipoproteins, microRNA, intestinal permeability, DNA, body weight), risk behaviors (diet, physical activity, sleep, smoking, alcohol consumption) and also determinants of these behaviors (physical and social environment) can provide answers that allow effective interventions in public health. Therefore, this proposal brings a broad and, at the same time, profound approach to the complex relationships regarding NCD in the population. (AU)

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Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CASTRO, MICHELLE ALESSANDRA; GARCEZ, MARCELA RICCIOPPO; PEREIRA, JAQUELINE LOPES; FISBERG, REGINA MARA. Eating behaviours and dietary intake associations with self-reported sleep duration of free-living Brazilian adults. APPETITE, v. 137, p. 207-217, . (12/22113-9, 17/05125-7)
DE MELLO, ALINE VERONEZE; PEREIRA, JAQUELINE LOPES; LEME, ANA CAROLINA BARCO; GOLDBAUM, MOISES; GALVAO CESAR, CHESTER LUIZ; FISBERG, REGINA MARA. Social determinants, lifestyle and diet quality: a population-based study from the 2015 Health Survey of Sao Paulo, Brazil. PUBLIC HEALTH NUTRITION, v. 23, n. 10, p. 1766-1777, . (12/22113-9, 17/05125-7)
DE MENESES FUJII, TATIANE MIEKO; NORDE, MARINA MAINTINGUER; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; ORDOVAS, JOSE M.; ROGERO, MARCELO MACEDO. FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women. Nutrition Research, v. 78, p. 42-49, . (12/20401-7, 17/05125-7, 09/15831-0, 12/22113-9, 16/03803-5)
PALCHETTI, CECILIA ZANIN; STELUTI, JOSIANE; SALES, CRISTIANE HERMES; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA. Folate and vitamin B12 status: temporal evaluation after mandatory fortification in Brazil. European Journal of Clinical Nutrition, v. N/A, p. 7-pg., . (09/15831-0, 12/22113-9, 17/05125-7)
BATISTA, LAIS DUARTE; GRANDE DE FRANCA, NATASHA APARECIDA; FONTANELLI, MARIANE DE MELLO; GRACIELA MARTINEZ-ARROYO, ANGELA; FISBERG, REGINA MARA. Misreporting of dietary energy intake obtained by 24 h recalls in older adults: a comparison of five previous methods using doubly labeled water. European Journal of Clinical Nutrition, . (18/01991-4, 17/05125-7)
INAIAN PIGNATTI TEIXEIRA; JAQUELINE LOPES PEREIRA; JOÃO PAULO DOS ANJOS SOUZA BARBOSA; ALINE VERONEZE DE MELLO; BIANCA MITIE ONITA; REGINA MARA FISBERG; ALEX ANTONIO FLORINDO. Validade da massa corporal e da estatura autorreferidas: relações com sexo, idade, atividade física e fatores de risco cardiometabólicos. Revista Brasileira de Epidemiologia, v. 24, . (20/01312-0, 12/22113-9, 17/05125-7, 17/17049-3)
BRANDAO-LIMA, PAULA N.; DE CARVALHO, GABRIELLI B.; PAYOLLA, TANYARA B.; SARTI, FLAVIA M.; FISBERG, REGINA M.; MALCOMSON, FIONA C.; MATHERS, JOHN C.; ROGERO, MARCELO M.. Circulating microRNAs Showed Specific Responses according to Metabolic Syndrome Components and Sex of Adults from a Population-Based Study. METABOLITES, v. 13, n. 1, p. 14-pg., . (17/05125-7, 20/03104-5, 19/22934-1)
BASTOS, AMALIA ALMEIDA; FELIX, PAULA VICTORIA; DE CASTRO, MICHELLE ALESSANDRA; FISBERG, REGINA MARA; YANNAKOULIA, MARY; RIBEIRO, SANDRA MARIA LIMA. Response to the critical analysis of the article 'Comparison and convergent validity of five Mediterranean dietary indexes applied to Brazilian adults and older adults: data from a population-based study (2015 ISA-Nutrition)'. JOURNAL OF NUTRITIONAL SCIENCE, v. 12, p. 2-pg., . (17/05125-7, 19/24213-0, 12/22113-9)
FONTANELLI, MARIANE DE MELLO; ARROYO, ANGELA MARTINEZ; SALES, CRISTIANE HERMES; SEAL, CHRIS J.; FISBERG, REGINA MARA. Opportunities for diet quality improvement: the potential role of staple grain foods. PUBLIC HEALTH NUTRITION, v. 24, n. 18, p. 6145-6156, . (16/18742-1, 12/22113-9, 17/05125-7)
LEME, ANA CAROLINA BARCO; HAINES, JESS; TANG, LISA; FISBERG, MAURO; FERRARI, GERSON; DA SILVA, VITORIA ALEXANDRA; FISBERG, REGINA MARA. Association between weight control behaviors and diet quality among Brazilian adolescents and young adults: Health Survey of Sao Paulo with Focus on Nutrition, 2015. Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity, v. 27, n. 2, p. 14-pg., . (17/05125-7, 15/20852-7)
SALES, CRISTIANE HERMES; FONTANELLI, MARIANE DE MELLO; ROGERO, MARCELO MACEDO; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. Dietary inadequacies overestimate the blood deficiencies of magnesium, zinc, and vitamins A, C, E, and D among residents of Sao Paulo. CLINICAL NUTRITION ESPEN, v. 53, p. 10-pg., . (17/05125-7, 12/22113-9, 19/05685-8)
BASTOS, AMALIA A.; FELIX, PAULA V.; CASTRO, MICHELLE A.; FISBERG, REGINA M.; SILVA, ANTONIO A. M.; YANNAKOULIA, MARY; RIBEIRO, SANDRA M. L.. Comparison and convergent validity of five Mediterranean dietary indexes applied to Brazilian adults and older adults: data from a population-based study (2015 ISA-Nutrition). JOURNAL OF NUTRITIONAL SCIENCE, v. 12, p. 10-pg., . (17/05125-7, 12/22113-9, 19/24213-0)
BATISTA, LAIS DUARTE; NETO, JOAO VALENTINI; DE FRANCA, NATASHA APARECIDA GRANDE; RIBEIRO, SANDRA MARIA LIMA; FISBERG, REGINA MARA. Body composition affects the accuracy of predictive equations to estimate resting energy expenditure in older adults: An exploratory study. CLINICAL NUTRITION ESPEN, v. 53, p. 7-pg., . (14/26787-0, 17/05125-7, 18/01991-4)
LOPES, TATIANE DOS SANTOS; DE MELLO, ALINE VERONEZE; NOGUEIRA, LUANA ROMAO; LEME, ANA CAROLINA BARCO; FISBERG, REGINA MARA. Energia, nutrientes e fontes alimentares em lanches de adolescentes e jovens adultos. Revista Paulista de Pediatria, v. 40, . (12/22113-9, 17/23115-9, 15/20852-7, 17/05125-7)
SALES, CRISTIANE HERMES; ROGERO, MARCELO MACEDO; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. Prevalence and Factors Associated with Iron Deficiency and Anemia among Residents of Urban Areas of Sao Paulo, Brazil. NUTRIENTS, v. 13, n. 6, . (19/05685-8, 17/05125-7, 12/22113-9)
FELIX, PAULA VICTORIA; PEREIRA, JAQUELINE LOPES; LEME, ANA CAROLINA BARCO; DE CASTRO, MICHELLE ALESSANDRA; FISBERG, REGINA MARA. Nutritional breakfast quality and cardiometabolic risk factors: Health Survey of Sao Paulo, a population-based study. PUBLIC HEALTH NUTRITION, v. 24, n. 13, p. 4102-4112, . (17/05125-7)
GARCEZ, MARCELA RICCIOPPO; DE CASTRO, MICHELLE ALESSANDRA; CESAR, CHESTER LUIS GALVAO; GOLDBAUM, MOISES; FISBERG, REGINA MARA. A chrononutrition perspective of diet quality and eating behaviors of Brazilian adolescents in associated with sleep duration. CHRONOBIOLOGY INTERNATIONAL, v. 38, n. 3, . (17/05125-7, 12/22113-9)
DE MELLO, ALINE VERONEZE; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. How to Estimate Food Prices and Diet Costs in Population-Based Studies?. FRONTIERS IN NUTRITION, v. 8, . (09/15831-0, 17/05125-7)

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