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Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications

Grant number: 18/08782-1
Support Opportunities:Research Projects - Thematic Grants
Duration: December 01, 2018 - November 30, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Mauro Bertotti
Grantee:Mauro Bertotti
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Marcelo Nelson Páez Carreño ; Thiago Regis Longo Cesar da Paixão
Associated researchers:Gustavo Pamplona Rehder ; Ines Pereyra ; Marco Isaías Alayo Chávez ; William Reis de Araujo
Associated grant(s):19/16491-0 - Rapid, onsite detection of toxic metals combining paper-based electrochemical sensors and fast-scan cyclic voltammetry, AP.R SPRINT
19/10606-0 - Multi-User Equipment approved in grant 2018/08782-1: photolithography system, AP.EMU
19/00811-5 - EMU granted in process 2018/08782-1: materials deposition system by ink-jet, AP.EMU
23/02572-3 - Using a portable potentiostat to get chemical information in rat brain, BP.TT
22/14473-7 - Modification of electrodic surfaces with porphyrazines towards the development of a nitric oxide electrochemical sensor, BP.IC
+ associated scholarships 22/03665-2 - Electrochemical sensors for hydrogen peroxide and calcium ions detection in biological systems, BP.DD
22/03643-9 - Study of the effect of ascorbic acid on protection against UV radiation in cells through the development of electrochemical nanosensors for localized and real-time detection, BP.DD
22/04980-9 - Calibration-free electrochemical microsensors for milk analysis, BP.DD
22/03382-0 - Wearable sensor for real time monitoring of drugs of abuse in human saliva, BP.PD
22/00064-8 - An electrochemical sensor for phosphate detection in water samples, BP.IC
21/00205-8 - Miniaturized and/or microfluidic analytical devices for biological applications, BP.PD
21/05806-0 - Portable miniaturized potentiostat with wireless communication: hardware components, BP.TT
21/09798-1 - Portable miniaturized potentiostat with wireless communication: hardware components, BP.TT
20/01612-3 - Study on Ca2+ diffusion through caffeine-containing xantana membranes using a potentiometric microsensor, BP.IC
19/23206-0 - Fabrication on an electrochemical sensor for no detection, BP.IC
19/15065-7 - Development of paper-based electrochemical systems aiming flow analysis of forensic samples, BP.DD
19/14418-3 - Electrochemical sensors for water quality monitoring, BP.DD
19/06293-6 - Investigations in biological systems by using miniaturized electrochemical sensors, BP.PD
19/00889-4 - Electrochemical determination of iodate in urine samples by redox cycling with microelectrodes, BP.MS - associated scholarships


Analytical chemistry techniques and technologies have rapidly emerged in the last years, but the cost and logistics for the samples collection at meaningful spatial scales and further analysis does not make their development and spread straightforward. Such problems can be better addressed by the fabrication of devices that operate autonomously at or near the sampling site, reducing the risks of error and contamination associated with manual sample acquisition, storage, and transport. This direct-reading chemical sensor operates by detecting and responding in a fast way to the presence or amount of an analyte at some interface between the sensor and the sample matrix. Those systems are capable of handling volumes on the microliter level and performing assays at short times, hence the miniaturization offers a suitable platform for portability and automation. Based on selected parameters, devices can be fabricated for analog signal gathering, processing, logging and remote presentation of data. Taking into account the above-mentioned, this research project aims at designing and developing integrated systems for real time monitoring of some target compounds at sites of environmental, health and biological relevance. The proposed devices will consist of several miniaturized electrochemical and optical sensors and emphasis will be given on apparatuses that can be easily implemented and possess reliable and long-time operation, as well as with wearable application. To achieve high selectivity toward the desired analytes, new platforms will be designed by using novel materials. In the absence of favorable selectivity, different strategies will be employed such as mathematical approaches (chemometric analysis) or the separation of the analyte from the sample matrix by using microfluidic devices. The developed sensors will have to satisfy analytical requirements (e.g. reduced drift response, resistance to surface fouling and high selectivity, accuracy and precision) as well as technological demands (mass-scale production at low cost, low power requirements and robust electronics). (AU)

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Scientific publications (38)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SUKERI, ANANDHAKUMAR; DE CARVALHO JUNIOR, EDUARDO JOSE; BERTOTTI, MAURO. A novel approach for one-step fabrication of platinum-nanoporous gold film via oxygen bubble template with enhanced electrochemical activity. Electrochemistry Communications, v. 100, p. 96-99, . (18/08782-1, 17/21585-8)
AMEKU, WILSON A.; DE ARAUJO, WILLIAM R.; RANGEL, CLARA J.; ANDO, ROMULO A.; PAIXAO, THIAGO R. L. C.. Gold Nanoparticle Paper-Based Dual-Detection Device for Forensics Applications. ACS APPLIED NANO MATERIALS, v. 2, n. 9, p. 5460-5468, . (16/21070-5, 17/10522-5, 18/08782-1, 16/16477-9)
DE LIMA, LUCAS F.; FERREIRA, ANDRE L.; MACIEL, CRISTIANE C.; FERREIRA, MARYSTELA; DE ARAUJO, WILLIAM R.. Disposable and low-cost electrochemical sensor based on the colorless nail polish and graphite composite material for tartrazine detection. Talanta, v. 227, . (19/02692-3, 18/08782-1, 18/04061-8)
ARJUNAN, ANANTHI; SUKERI, ANANDHAKUMAR; SARAIVA, DOUGLAS PHILIP MARTINEZ; MIRANDA, PAULO BARBEITAS; BERTOTTI, MAURO. Electrochemical Studies of Hydrogen Peroxide Oxidation on a Nanoporous Gold Surface: Fundamental and Analytical Applications. Journal of the Electrochemical Society, v. 167, n. 11, . (18/08782-1, 18/02819-0)
MENDES, LETICIA FRANCINE; DE SIERVO, ABNER; DE ARAUJO, WILLIAM REIS; LONGO CESAR PAIXAO, THIAGO REGIS. Reagentless fabrication of a porous graphene-like electrochemical device from phenolic paper using laser-scribing. Carbon, v. 159, p. 110-118, . (17/10522-5, 18/08782-1, 07/54829-5, 18/16250-0)
ATAIDE, VANESSA N.; MENDES, LETICIA F.; GAMA, LILLIA I. L. M.; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.. Electrochemical paper-based analytical devices: ten years of development. ANALYTICAL METHODS, v. 12, n. 8, p. 1030-1054, . (17/10522-5, 18/14462-0, 18/08782-1, 16/16477-9, 19/16491-0)
DE LIMA, LUCAS F.; FERREIRA, ANDRE L.; TORRES, MARCELO D. T.; DE ARAUJO, WILLIAM R.; DE LA FUENTE-NUNEZ, CESAR. Minute-scale detection of SARS-CoV-2 using a low-cost biosensor composed of pencil graphite electrodes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 118, n. 30, . (18/08782-1)
AMEKU, WILSON A.; GONCALVES, JOSUE M.; ATAIDE, VANESSA N.; SANTOS, MAURO S. FERREIRA; GUTZ, IVANO G. R.; ARAKI, KOITI; PAIXAO, THIAGO R. L. C.. Combined Colorimetric and Electrochemical Measurement Paper-Based Device for Chemometric Proof-of-Concept Analysis of Cocaine Samples. ACS OMEGA, v. 6, n. 1, p. 594-605, . (17/10522-5, 19/16491-0, 16/21070-5, 18/08782-1)
ORTEGA, FRANCISCO G.; REGIART, MATIAS D.; RODRIGUEZ-MARTINEZ, ALBA; DE MIGUEL-PEREZ, DIEGO; SERRANO, MARIA J.; LORENTE, JOSE A.; TORTELLA, GONZALO; RUBILAR, OLGA; SAPAG, KARIM; BERTOTTI, MAURO; et al. Sandwich-Type Electrochemical Paper-Based Immunosensor for Claudin 7 and CD81 Dual Determination on Extracellular Vesicles from Breast Cancer Patients. Analytical Chemistry, v. 93, n. 2, p. 1143-1153, . (18/08782-1, 19/06293-6)
ATAIDE, VANESSA N.; AMEKU, WILSON A.; BACIL, RAPHAEL R.; ANGNES, LUCIO; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.. Enhanced performance of pencil-drawn paper-based electrodes by laser-scribing treatment. RSC ADVANCES, v. 11, n. 3, p. 1644-1653, . (18/14462-0, 16/21070-5, 18/08782-1, 16/16477-9, 17/10522-5)
TORRES, MARCELO D. T.; DE ARAUJO, WILLIAM R.; DE LIMA, LUCAS F.; FERREIRA, ANDRE L.; DE LA FUENTE-NUNEZ, CESAR. Low-cost biosensor for rapid detection of SARS-CoV-2 at the point of care. MATTER, v. 4, n. 7, p. 2403-2416, . (18/08782-1)
GROTHE, RENATA A.; LOBATO, ALNILAN; MOUNSSEF, BASSIM; TASI, NIKOLA; BRAGA, ATAUALPA A. C.; MALDANER, ADRIANO O.; ALDOUS, LEIGH; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Electroanalytical profiling of cocaine samples by means of an electropolymerized molecularly imprinted polymer using benzocaine as the template molecule. ANALYST, v. 146, n. 5, p. 1747-1759, . (19/05569-8, 18/13922-7, 14/25770-6, 15/01491-3, 18/14425-7, 18/08782-1, 19/11214-8)
REGIART, MATIAS; KUMAR, ABHISHEK; GONCALVES, JOSUE M.; SILVA JUNIOR, GILBERTO J.; MASINI, JORGE CESAR; ANGNES, LUCIO; BERTOTTI, MAURO. An Electrochemically Synthesized Nanoporous Copper Microsensor for Highly Sensitive and Selective Determination of Glyphosate. CHEMELECTROCHEM, v. 7, n. 7, p. 1558-1566, . (18/16896-7, 19/14418-3, 18/08782-1, 19/06293-6)
FERREIRA, ANDRE LOPES; DE LIMA, LUCAS FELIPE; TOROSSIAN TORRES, MARCELO DER; DE ARAUJO, WILLIAM REIS; DE LA FUENTE-NUNEZ, CESAR. ow-Cost Optodiagnostic for Minute-Time Scale Detection of SARS-CoV-. ACS NANO, v. 15, n. 11, p. 17453-17462, . (18/08782-1)
TASIC, NIKOLA; CAVALCANTE, LETICIA; DEFFUNE, ELENICE; GOES, MARCIO SOUSA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Probeless and label-free impedimetric biosensing of D-dimer using gold nanoparticles conjugated with dihexadecylphosphate on screen-printed carbon electrodes. Electrochimica Acta, v. 397, . (18/13922-7, 18/08782-1, 17/10522-5, 18/14425-7)
DIAS, ANDERSON A.; CHAGAS, CYRO L. S.; SILVA-NETO, HABDIAS DE A.; LOBO-JUNIOR, EULICIO O.; SGOBBI, LIVIA F.; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.; COLTRO, WENDELL K. T.. Environmentally Friendly Manufacturing of Flexible Graphite Electrodes for a Wearable Device Monitoring Zinc in Sweat. ACS APPLIED MATERIALS & INTERFACES, v. 11, n. 43, p. 39484-39492, . (17/10522-5, 18/08782-1)
HERNANDEZ-SARAVIA, LUCAS PATRICIO; SUKERI, ANANDHAKUMAR; BERTOTTI, MAURO. Fabrication of nanoporous gold-islands via hydrogen bubble template: An efficient electrocatalyst for oxygen reduction and hydrogen evolution reactions. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, v. 44, n. 29, p. 15001-15008, . (18/08782-1)
KUMAR, ABHISHEK; FURTADO, VINICIUS L.; GONCALVES, JOSUE M.; BANNITZ-FERNANDES, RENATA; NETTO, LUIS EDUARDO S.; ARAKI, KOITI; BERTOTTI, MAURO. Amperometric microsensor based on nanoporous gold for ascorbic acid detection in highly acidic biological extracts. Analytica Chimica Acta, v. 1095, p. 61-70, . (18/08782-1, 18/21489-1, 18/09027-2)
SUKERI, ANANDHAKUMAR; ARJUNAN, ANANTHI; BERTOTTI, MAURO. New strategy to fabricate a polydopamine functionalized self-supported nanoporous gold film electrode for electrochemical sensing applications. Electrochemistry Communications, v. 110, . (14/15215-5, 18/08782-1)
FERREIRA E SILVA, RAFAEL; LONGO CESAR PAIXAO, THIAGO REGIS; TOROSSIAN TORRES, MARCELO DER; DE ARAUJO, WILLIAM REIS. Simple and inexpensive electrochemical paper-based analytical device for sensitive detection of Pseudomonas aeruginosa. SENSORS AND ACTUATORS B-CHEMICAL, v. 308, . (17/11398-6, 17/10522-5, 18/08782-1, 16/16477-9)
CLARK, KAYLEE M.; SKRAJEWSKI, LAUREN; BENAVIDEZ, TOMAS E.; MENDES, LETICIA F.; BASTOS, ERICK L.; DORR, FELIPE A.; SACHDEVA, RAKESH; OGALE, AMOD A.; PAIXAO, THIAGO R. L. C.; GARCIA, CARLOS D.. Fluorescent patterning of paper through laser engraving. SOFT MATTER, v. 16, n. 33, p. 7659-7666, . (18/16250-0, 18/08782-1)
REGIART, MATIAS; GIMENEZ, ALBA MARINA; LOPES, ALEXANDRE T.; CARRENO, MARCELO N. P.; BERTOTTI, MAURO. Ultrasensitive microfluidic electrochemical immunosensor based on electrodeposited nanoporous gold for SOX-2 determination. Analytica Chimica Acta, v. 1127, p. 122-130, . (18/08782-1, 19/06293-6)
BALDO, THAISA A.; DE LIMA, LUCAS FELIPE; MENDES, LETICIA F.; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.; COLTRO, WENDELL K. T.. Wearable and Biodegradable Sensors for Clinical and Environmental Applications. ACS APPLIED ELECTRONIC MATERIALS, v. 3, n. 1, p. 68-100, . (18/16250-0, 18/08782-1, 19/16491-0)
DIP GANDARILLA, ARIAMNA MARIA; REGIART, MATIAS; BERTOTTI, MAURO; CORREA GLORIA, JULIANE; MORAIS MARIUBA, LUIS ANDRE; BRITO, WALTER RICARDO. One-step enzyme-free dual electrochemical immunosensor for histidine-rich protein 2 determination. RSC ADVANCES, v. 11, n. 1, p. 408-415, . (18/08782-1, 19/06293-6)
FREITAS, RAFAELA C.; ORZARI, LUIZ O.; FERREIRA, LUIS M. C.; PAIXAO, THIAGO R. L. C.; COLTRO, WENDELL K. T.; VICENTINI, FERNANDO C.; JANEGITZ, BRUNO C.. Electrochemical determination of melatonin using disposable self-adhesive inked paper electrode. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 897, . (17/21097-3, 19/24428-6, 19/23342-0, 18/08782-1)
KUMAR, ABHISHEK; SELVA, JESSICA S. G.; GONCALVES, JOSUE M.; ARAKI, KOITI; BERTOTTI, MAURO. Nanoporous gold-based dopamine sensor with sensitivity boosted by interferant ascorbic acid. Electrochimica Acta, v. 322, . (18/08782-1)
REGIART, MATIAS; GIMENEZ, ALBA MARINA; MARQUES, RODOLFO F.; SOARES, IRENE S.; BERTOTTI, MAURO. Microfluidic device based on electrodeposited Nanoporous Gold/Carbon Nanotubes for Plasmodium vivax detection. SENSORS AND ACTUATORS B-CHEMICAL, v. 340, . (16/50108-0, 19/06293-6, 18/08782-1)
SILVA JUNIOR, GILBERTO J.; GUIMARAES SELVA, JESSICA SOARES; SUKERI, ANANDHAKUMAR; GONCALVES, JOSUE M.; REGIART, MATIAS; BERTOTTI, MAURO. Fabrication of dendritic nanoporous gold via a two-step amperometric approach: Application for electrochemical detection of methyl parathion in river water samples. Talanta, v. 226, . (19/14418-3, 18/16896-7, 18/08782-1, 19/06293-6)
KUMAR, ABHISHEK; GONCALVES, JOSUE M.; SELVA, JESSICA S. G.; ARAKI, KOITI; BERTOTTIZ, MAURO. Correlating Selective Electrocatalysis of Dopamine and Ascorbic Acid Electrooxidation at Nanoporous Gold Surfaces with Structural-Defects. Journal of the Electrochemical Society, v. 166, n. 14, p. H704-H711, . (13/24725-4, 18/08782-1)
TASIC, NIKOLA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Biosensing of D-dimer, making the transition from the central hospital laboratory to bedside determination. Talanta, v. 207, . (17/10522-5, 18/08782-1, 18/13922-7, 18/14425-7)
KUMAR, ABHISHEK; GONCALVES, JOSUE M.; LIMA, ALAN R.; MATIAS, TIAGO A.; NAKAMURA, MARCELO; BERNARDES, JULIANA S.; ARAKI, KOITI; BERTOTTI, MAURO. Efficient and methanol resistant noble metal free electrocatalyst for tetraelectronic oxygen reduction reaction. Electrochimica Acta, v. 326, . (18/08782-1, 18/21489-1)
FERREIRA, PATRICK CESAR; ATAIDE, VANESSA NEIVA; SILVA CHAGAS, CYRO LUCAS; ANGNES, LUCIO; TOMAZELLI COLTRO, WENDELL KARLOS; LONGO CESAR PAIXAO, THIAGO REGIS; DE ARAUJO, WILLIAM REIS. Wearable electrochemical sensors for forensic and clinical applications. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 119, . (18/14462-0, 17/10522-5, 16/16477-9, 18/08782-1)
SANTOS, CARLA S.; MACEDO, FELIPE; KOWALTOWSKI, ALICIA J.; BERTOTTI, MAURO; UNWIN, PATRICK R.; DA CUNHA, FERNANDA MARQUES; MELONI, GABRIEL N.. Unveiling the contribution of the reproductive system of individual Caenorhabditis elegans on oxygen consumption by single-point scanning electrochemical microscopy measurements. Analytica Chimica Acta, v. 1146, p. 88-97, . (13/07937-8, 14/22396-6, 18/08782-1)
PATRICIO HERNANDEZ-SARAVIA, LUCAS; MARTINEZ, TAMARA; LLANOS, JAIME; BERTOTTI, MAURO. A Cu-NPG/SPE sensor for non-enzymatic and non-invasive electrochemical glucose detection. Microchemical Journal, v. 160, n. A, . (18/08782-1)
PIGUILLEM, SOFIA V.; REGIART, MATIAS; BERTOTTI, MAURO; RABA, JULIO; MESSINA, GERMAN A.; FERNANDEZ-BALDO, MARTIN A.. Microfluidic fluorescence immunosensor using ZnONFs for invasive aspergillosis determination. Microchemical Journal, v. 159, . (19/06293-6, 18/08782-1)
ROCHA, DIEGO P.; ATAIDE, VANESSA N.; DE SIERVO, ABNER; GONSALVES, JOSUE M.; MUNOZ, RODRIGO A. A.; PAIXA, THIAGO R. L. C.; ANGNES, LUCIO. Reagentless and sub-minute laser-scribing treatment to produce enhanced disposable electrochemical sensors via additive manufacture. CHEMICAL ENGINEERING JOURNAL, v. 425, . (07/08244-5, 18/14462-0, 07/54829-5, 18/16896-7, 14/50867-3, 18/08782-1, 20/00325-0)

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