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Effect of metalloproteinases inhibitors and/or remineralizing agents on tooth structure submitted to erosion

Grant number: 18/05847-5
Support Opportunities:Regular Research Grants
Duration: December 01, 2018 - January 31, 2022
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Heitor Marques Honório
Grantee:Heitor Marques Honório
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated researchers:Daniela Rios Honório


Due to the high prevalence of dental erosion found in recent years, therapies are sought to prevent the occurrence or inhibit the progress of this alteration. Proanthocyanidin is an agent currently studied because of its properties, which among others, involves remineralization, reduction of demineralization and biomodification of dentin, inhibiting matrix metalloproteinases (MMPs) that degrade the dentin collagen. Thus, the objective of this study is to evaluate the role of Proanthocyanidin-based agents (gel and toothpaste) in the prevention of tooth wear (enamel and dentin) and degradation of the organic matrix of the demineralized dentin. To do this, 6 subprojects will be carried out: Subproject 1 - will be evaluated the effect of fluoridated remineralizing agents applied on eroded dentin, treated previously or not with collagen degradation inhibitors (among them Proanthocyanidin), on the dentin erosion; Subproject 2- will be chemically evaluated the surface of enamel and dentin, sound and eroded, with and without treatment with preventive agents developed for caries and erosion (among them Proanthocyanidin); Subprojects 3 and 4 - will be evaluate in vitro and in situ, respectively, a Proanthocyanidin based dentifrice on the wear resistance of the dentin subjected to erosion associated with abrasion; Subproject 5- Proanthocyanidin gel will be evaluated in the minimization of dentin wear and possible inhibition of demineralized organic matrix degradation; Subproject 6- will evaluate the effect of Proanthocyanidin with and without the presence of acquired pellicle in the inhibition of enamel erosion. In subprojects 1, 3, 4 and 5 the dependent variable will be the wear evaluation by profilometry. In subproject 2, the specimens will be chemically evaluated using XPS and EDX. The specimens of subproject 5 will also be evaluated for the degree of degradation of the organic matrix demineralized by the ELISA method. In subproject 6, the response variable will be the percentage of loss of surface hardness. The data will be analyzed by simple or factorial ANOVA tests, followed by multiple comparison tests, in addition to Multiple Linear Regression models, adopting a significance level of 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FABRÍCIA CARDOSO; ANA PAULA BOTEON; TAMIRES ALVES PEREIRA DA SILVA; ANURADHA PRAKKI; LINDA WANG; HEITOR MARQUES HONÓRIO. In situ effect of a proanthocyanidin mouthrinse on dentin subjected to erosion. Journal of Applied Oral Science, v. 28, . (18/05847-5)
VERTUAN, MARIELE; SOUZA, BEATRIZ MARTINES; MOSQUIM, VICTOR; SILVA, CAMILA VIEIRA; FREITAS, PATRICIA MOREIRA; BORGES, ANA FLAVIA SANCHES; RIOS, DANIELA; MAGALHAES, ANA CAROLINA; HONORIO, HEITOR MARQUES. Effect of TiF4 varnish after pre-treatment with proanthocyanidin or chlorhexidine on the progression of erosive dentin loss in the presence or absence of the demineralized organic matrix. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 115, . (18/05847-5)
BOTEON, ANA PAULA; DALLAVILLA, GABRIELA GUARDA; CARDOSO, FABRICIA; WANG, LINDA; RIOS, DANIELA; HONORIO, HEITOR MARQUES. Proanthocyanidin protects the enamel against initial erosive challenge when applied over acquired pellicle. AMERICAN JOURNAL OF DENTISTRY, v. 33, n. 5, p. 4-pg., . (18/05847-5)

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