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Search for potential antitumoral, antioxidant, antiinflammatory, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest

Grant number: 04/07932-7
Support Opportunities:BIOTA-FAPESP Program - Thematic Grants
Duration: March 01, 2005 - July 31, 2010
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Dulce Helena Siqueira Silva
Grantee:Dulce Helena Siqueira Silva
Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Pesquisadores principais:
Alberto Jose Cavalheiro
Associated grant(s):07/51452-8 - Rapid screening of antioxidant and antimalarial compounds from natural complex matrixes using hplc-micro fraction analysis: application to crude extracts from chiococca alba., AR.EXT
Associated scholarship(s):07/50348-2 - Biomonitored phytochemical study of Casearia lasiophylla (Flacourtiaceae), BP.IC
06/60150-2 - Configurational analysis of styrylpyrones of species of Cryptocarya (Lauraceae), BP.IC
06/60151-9 - Chromatographic profile of the metabolites of species of the Flacourtiaceae family: biomonitored phytochemcial study, BP.DR
+ associated scholarships 06/60152-5 - Optimization and validation of method for the extraction and analysis of casearines of Casearia sylvestris, by CLAE, BP.IC
06/60891-2 - Tracing of genotoxicity of antimutagenesis of semi-purified fractions extracted from Pterogyne nitens using the test of the micronucleus in Tradescantia pallida, BP.IC
06/57101-0 - Phytochemical study of the antioxidant and cytotoxic activities of Myrciaria cauliflora Berg. (Myrtaceae), BP.IC
06/57114-4 - Implantation of trials for triage on a greater scale using a micro-circuit board multidetection reader for analysis of vegetal extracts and substances, BP.PD
06/55162-1 - Chemical and antioxidant studies of two species of the Lippia genus native to the São Paulo cerrado: L. salviaefolia and L. velutina (Berbenaceae), BP.DR
05/60029-6 - Antiproliferative and cytoxic evaluation of potential inhibitors of hypusination of the factor of the 5th translation initiation (EIF5A), BP.IC
05/56867-6 - Search for potential antitumoral, antioxidant, antiinflammatory, antifungal, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest, BP.TT
05/52930-5 - Chemical study and study of the biological activities of Eugenia jambolana (Myrtaceae), BP.MS - associated scholarships

Abstract

The changing strategies for preservation and sustainable of diversity in Brazil in the past few years evidences the intrinsic value this enormous biological resource of potentially new bioactive compounds, and represents one of the greatest challenges nowadays facing the accelerated process of devastation of several Brazilian biomes. The systematic bioactivity evaluation of crude extracts and pure compounds from São Paulo state biota associated with additional information on chromatographic profile, spectrometric data and/or biological activity shall result in value-added material, which will be available for further studies. The might converge to hits or lead compounds to pharmaceutical, agroceutical, nutraceutical, cosmetics industry, which is expected to bring great contribution for conservation and sustainable economic development from the biodiversity of São Paulo state. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAMETTO, ALESSANDRA C.; AGUSTONI, DANIELE; MOREIRA, THAIS F.; PLAZA, CARENINA V.; PRIETO, ALINE M.; SILVA, TARSIA G. A.; SOUZA, FELIPE O.; BORALLE, NIVALDO; SORBO, JULIANA MARIA; SILVA, DULCE H. S.; et al. Chemical composition and in vitro chemoprevention assessment of Eugenia jambolana Lam. (Myrtaceae) fruits and leaves. Journal of Functional Foods, v. 36, p. 490-502, . (13/07600-3, 04/07932-7)
DAMETTO, ALESSANDRA C.; BORALLE, NIVALDO; ZHANG, CHUAN-RUI; SILVA, DULCE H. S.; NAIR, MURALEEDHARAN G.. Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds. NATURAL PRODUCT COMMUNICATIONS, v. 13, n. 8, p. 977-980, . (13/07600-3, 04/07932-7)
FERNANDES, DANIARA CRISTINA; REGASINI, LUIS OCTÁVIO; VELLOSA, JOSÉ CARLOS REBUGLIO; PAULETTI, PATRÍCIA MENDONÇA; CASTRO-GAMBOA, IAN; BOLZANI, VANDERLAN SILVA; OLIVEIRA, OLGA MARIA MASCARENHAS; SILVA, DULCE HELENA SIQUEIRA. Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. Chemical & Pharmaceutical Bulletin, v. 56, n. 5, p. 723-726, . (04/07932-7)
PRIETO, ALINE M.; DOS SANTOS, ANDRE G.; OLIVEIRA, ANA PAULA S.; CAVALHEIRO, ALBERTO J.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; VARANDA, ELIANA AP.; SOARES, CHRISTIANE P.. Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae). Food and Chemical Toxicology, v. 53, p. 153-159, . (03/02176-7, 04/07932-7)
PRIETO, A. M.; SANTOS, A. G.; CSIPAK, A. R.; CALIRI, C. M.; SILVA, I. C.; ARBEX, M. A.; SILVA, F. S.; MARCHI, M. R. R.; CAVALHEIRO, A. J.; SILVA, D. H. S.; et al. Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil. Toxicology and Applied Pharmacology, v. 265, n. 3, p. 368-372, . (03/02176-7, 04/07932-7)
REGASINI, LUIS OCTAVIO; PIVATTO, MARCOS; SCORZONI, LILIANA; BENADUCCI, TATIANE; FUSCO-ALMEIDA, ANA MARISA; SOARES MENDES GIANNINI, MARIA JOSE; BARREIRO, ELIEZER JESUS; SIQUEIRA SIVA, DULCE HELENA; BOLZANI, VANDERLAN DA SILVA. Atividade antimicrobiana de Pterogyne nitens Tul., Fabaceae, contra fungos oportunistas. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 20, n. 5, p. 706-711, . (04/07932-7)
DE OLIVEIRA, ALINE M.; DOS SANTOS, ANDRE G.; DOS SANTOS, RAQUEL A.; CSIPAK, ANGELICA R.; OLIVATO, CAMILA; DA SILVA, ISABEL C.; DE FREITAS, MAURA B.; BASSI, CARMEN L.; CAVALHEIRO, ALBERTO J.; BOLZANI, VANDERLAN S.; et al. Ethanolic extract of Casearia sylvestris and its clerodane diterpen (caseargrewiin F) protect against DNA damage at low concentrations and cause DNA damage at high concentrations in mice's blood cells. MUTAGENESIS, v. 24, n. 6, p. 501-506, . (03/02176-7, 04/07932-7)
ORLANDI SARDI, JANAINA DE CASSIA; PITANGUI, NAYLA DE SOUZA; RODRIGUEZ-ARELLANES, GABRIELA; LUCIA TAYLOR, MARIA; FUSCO-ALMEIDA, ANA MARIA; SOARES MENDES-GIANNINI, MARIA JOSE. Highlights in pathogenic fungal biofilms. REVISTA IBEROAMERICANA DE MICOLOGIA, v. 31, n. 1, p. 22-29, . (11/12734-3, 03/02176-7, 04/07932-7, 12/01270-9)
FLAUSINO, JR., O. A.; DUFAU, L.; REGASINI, L. O.; PETRONIO, M. S.; SILVA, D. H. S.; ROSE, T.; BOLZANI, V. S.; REBOUD-RAVAUX, M.. Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization. Current Medicinal Chemistry, v. 19, n. 26, p. 4534-4540, . (03/02176-7, 04/07932-7)
FUNARI, CRISTIANO SOLEO; PASSALACQUA, THAIS GABAN; RINALDO, DANIEL; NAPOLITANO, ASSUNTA; FESTA, MICHELA; CAPASSO, ANNA; PIACENTE, SONIA; PIZZA, COSIMO; MARX YOUNG, MARIA CLAUDIA; DURIGAN, GISELDA; et al. Interconverting flavanone glucosides and other phenolic compounds in Lippia salviaefolia Cham. ethanol extracts. Phytochemistry, v. 72, n. 16, p. 2052-2061, . (04/07932-7)
LUIS OCTÁVIO REGASINI; GERARDO MAGELA VIEIRA-JÚNIOR; DANIARA CRISTINA FERNANDES; VANDERLAN DA SILVA BOLZANI; ALBERTO JOSÉ CAVALHEIRO; DULCE HELENA SIQUEIRA SILVA. IDENTIFICATION OF TRITERPENES AND STEROLS FROM PTEROGYNE NITENS (FABACEAE-CAESALPINIOIDEAE) USING HIGH-RESOLUTION GAS CHROMATOGRAPHY. Journal of the Chilean Chemical Society, v. 54, n. 3, p. 218-221, . (04/07932-7)
FUNARI, CRISTIANO SOLEO; GULLO, FERNANDA PATRICIA; NAPOLITANO, ASSUNTA; CARNEIRO, RENATO LAJARIM; SOARES MENDES-GIANNINI, MARIA JOSE; FUSCO-ALMEIDA, ANA MARISA; PIACENTE, SONIA; PIZZA, COSIMO; SIQUEIRA SILVA, DULCE HELENA. Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil. Food Chemistry, v. 135, n. 3, p. 2086-2094, . (04/07932-7)
MORAIS, MAURO C. C.; LUQMAN, SUAIB; KONDRATYUK, TAMARA P.; PETRONIO, MAICON S.; REGASINI, LUIS O.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; SOARES, CHRISTIANE P.; PEZZUTO, JOHN M.. Suppression of TNF- induced NFB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. NATURAL PRODUCT RESEARCH, v. 24, n. 18, p. 1758-1765, . (04/07932-7)
CRISTIANO S. FUNARI; LETÍCIA DE ALMEIDA; THAIS G. PASSALACQUA; ISABEL MARTINEZ; DANIELA L. AMBRÓSIO; REGINA MARIA B. CICARELLI; DULCE HELENA S. SILVA; MÁRCIA A. S. GRAMINHA. Ácido oleanônico isolado de Lippia lupulina (Verbenaceae) apresenta potentes atividades leishmanicida e tripanocida. Acta Amazonica, v. 46, n. 4, p. 411-416, . (04/07932-7, 06/55162-1)
SARA REGINA DE MARQUI; RENATA BRIONÍZIO LEMOS; LUCIANA ÁVILA SANTOS; IAN CASTRO-GAMBOA; ALBERTO JOSÉ CAVALHEIRO; VANDERLAN DA SILVA BOLZANI; DULCE HELENA SIQUEIRA SILVA; LILIANA SCORZONI; ANA MARIA FUSCO-ALMEIDA; MARIA JOSÉ SOARES MENDES-GIANNINI; et al. Saponinas antifúngicas de Swartzia langsdorffii. Química Nova, v. 31, n. 4, p. 828-831, . (04/07932-7, 03/02176-7)

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