Synthesis of metal complexes with bioactive N,N or N,O-coordinating ligands for use in sustainable delivery system based on bacterial cellulose

Abstract

Metallic complexes have been used since ancient times in medicine to treat various diseases. As an example, Au (I) complexes, such as auranofin, used clinically in the treatment of rheumatoid arthritis, Ag (I) complexes, which have antimicrobial properties, such as silver sulfadiazine, topically used in severe burns for the prevention of bacterial infections as well as the platinum metal complexes, such as cisplatin, carboplatin, oxaliplatin, nedaplatin and lobaplatin used in the treatment of cancer. In the case of cancer, chemotherapy represents the backbone of treatment for many types of tumors at different stages of evolution, although in many cases resistance to chemotherapy may occur, which may determine the therapeutic failure and, generally, the death of the tumor. patient. In addition to cancer, the indiscriminate use of antibacterial agents has provided the selection of resistant and increasingly virulent species of pathogenic bacteria, associated with human infections, which brings serious difficulties to the effectiveness of the treatment with the antimicrobials used in the clinic. Thus, development of coordination compounds with antitumor, antimicrobial, efficacy and safety, and interactions with biomolecules can revolutionize the therapeutic arsenal for the treatment of these diseases, especially in the case of resistance. Currently, the use of biopolymers as support and release of drugs has gained great importance in medicine. Among these polymers, bacterial cellulose (CB) is a great promise in biomedical applications because of its combination of biocompatibility and great versatility. CB, in different forms, has already been applied in the treatment of various types of injuries such as barriers and supports in the regeneration of periodontal tissues, temporary artificial skin for burns and ulcers and artificial blood vessels for microsurgery and support for drug release. The objective of this research project is to synthesize metallic complexes of copper (II), silver (I), gold (III), zinc (II), Mg (II), palladium (II), platinum bioactive binders 4-aminobenzoic acid (pABA), allopurinol, 1-hydroxybenzotriazole (HoBt) and probenecid for applications as antimicrobial agents for topical use and as antitumor, as well as incorporate the metal complexes into polymeric and nanostructured carriers. The present project also aims to produce pure CB membranes using the genus G. hansenii ATCC 23769 original, G. hansenii ATCC 23769 genetically modified and hybrid membrane production, from co-cultures with the other biopolymer producing species as P. aeruginosa (ATCC 27853) and Capriavidus necator ATCC17699, in order to obtain membranes with special fiber interlacing characteristics for use as support for sustained release of the free and incorporated metal complexes incorporated into the polymer carriers. (AU)