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Molecular epidemiology and genomic perspectives on the evolution and spread of emerging fungal pathogens

Abstract

Fungal diseases kill more than 1.5 million individuals and affect more than one billion people annually around the world. These infections are still neglected by public health authorities, although most deaths are preventable. In this project, we propose to explore emerging pathogens among some of the main Brazilian mycoses, including Aspergillosis, Fusariosis, Sporotrichosis, and Paracoccidioidomycosis, integrating study systems (epidemiology, diagnosis, and genomics), expanding national and international networking. Our aims are to identify, diagnose and understand how fungal epidemics develop. The first topic of this project uses molecular epidemiology methods to investigate the pathogen-host-environment interplay, disease transmission pathways, and disease emergence. Key issues such as epidemiology, population structure, genetic diversity and host association will be extensively explored. The second topic aims to identify new genetic and proteomic markers that can be used in the early diagnosis of fungal infections using as the main strategy the detection of a marker in tissue samples and biological fluids. Diagnostic tests are essential for patient follow-up and disease control. Misdiagnosis or lack there of results in public health problems, whether due to failure to treat or inadequate therapy. The third topic employs next-generation sequencing and comparative genomics for molecular typing as well as understanding the evolution and dispersion of fungal epidemics, making it possible to track current outbreaks and epidemics in Brazil. These pieces of information provide a unique opportunity to study the biology and evolution of medically-relevant fungi. Our experimental approach is a first step towards recognizing epidemiological and evolutionary trajectories of pathogens aiming to propose better public health policies to contain fungal epidemics and therefore reduce the number of infections in animals and humans or prevent the emergence of new pathogens. (AU)

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Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MASCHIO-LIMA, TAIZA; RIBEIRO MARQUES, MARIELA DOMICIANO; LEMES, THIAGO HENRIQUE; BRIZZOTTI-MAZUCHI, NATALIA SERON; CAETANO, MAICON HENRIQUE; DE ALMEIDA, BIANCA GOTTARDO; BIANCO, LETICIA MONTEIRO; MONTEIRO, RUAN CAMPOS; RODRIGUES, ANDERSON MESSIAS; DE CAMARGO, ZOILO PIRES; SIQUEIRA, JOAO PAULO ZEN; GOTTARDO DE ALMEIDA, MARGARETE TERESA. Clinical and epidemiological aspects of feline sporotrichosis caused by Sporothrix brasiliensis and in vitro antifungal susceptibility. VETERINARY RESEARCH COMMUNICATIONS, v. 45, n. 4, p. 171-179, DEC 2021. Web of Science Citations: 0.
DELLA TERRA, PAULA PORTELLA; GONSALES, FERNANDA FIDELIS; DE CARVALHO, JAMILE AMBROSIO; HAGEN, FERRY; KANO, RUI; BONIFAZ, ALEXANDRO; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS. Development and evaluation of a multiplex qPCR assay for rapid diagnostics of emerging sporotrichosis. TRANSBOUNDARY AND EMERGING DISEASES, NOV 2021. Web of Science Citations: 0.
DE CARVALHO, JAMILE AMBROSIO; PINHEIRO, BRENO GONCALVES; HAGEN, FERRY; GONCALVES, SARAH SANTOS; NEGRONI, RICARDO; KANO, RUI; BONIFAZ, ALEXANDRO; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS. A new duplex PCR assay for the rapid screening of mating-type idiomorphs of pathogenic Sporothrix species. FUNGAL BIOLOGY, v. 125, n. 10, p. 834-843, OCT 2021. Web of Science Citations: 1.
DE CARVALHO, J. A.; BEALE, M. A.; HAGEN, F.; FISHER, M. C.; KANO, R.; BONIFAZ, A.; TORIELLO, C.; NEGRONI, R.; REGO, R. S. DE M.; GREMIAO, I. D. F.; PEREIRA, S. A.; DE CAMARGO, Z. P.; RODRIGUES, A. M. rends in the molecular epidemiology and population genetics of emerging Sporothrix specie. STUDIES IN MYCOLOGY, n. 100 SEP 2021. Web of Science Citations: 1.
MAIFREDE, SIMONE BRAVIM; KRUSCHEWSKY, WDSON LUIS LIMA; PATRICIO, SUZANA ALVES; FALQUETO, ALOISIO; PECANHA, PAULO MENDES; MALAQUIAS, LUIZ COSME COTTA; POSSA, ANA PAULA; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS; GONCALVES, SARAH SANTOS; GRAO-VELLOSO, TANIA REGINA. Screening paracoccidioidomycosis by double immunodiffusion test in a referred diagnostic center in Brazilian southeastern: an accessible tool. INFECTION, v. 49, n. 6 SEP 2021. Web of Science Citations: 0.
ROBERTO, T. N.; DE CARVALHO, J. A.; BEALE, M. A.; HAGEN, F.; FISHER, M. C.; HAHN, R. C.; DE CAMARGO, Z. P.; RODRIGUES, A. M. xploring genetic diversity, population structure, and phylogeography in Paracoccidioides species using AFLP marker. STUDIES IN MYCOLOGY, n. 100 SEP 2021. Web of Science Citations: 2.
NERY, ANDREIA FERREIRA; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS; PORTELA, TIAGO FERREIRA; HOFFMANN-SANTOS, HUGO DIAS; KRUGER DAMBROS, PEDRO VITOR; RIBEIRO DE SOUZA, JANIO FELIPE; GARCIA, ALEXANDRE CARVALHO; DAMASIO SANTOS, CAROLINA ARAUJO; HAGEN, FERRY; HAHN, ROSANE CHRISTINE. Paracoccidioidomycosis due to P lutzii: The importance of neutrophil/lymphocyte ratio in the symptomatic and asymptomatic phases in severe cases. MYCOSES, v. 64, n. 8, p. 874-881, AUG 2021. Web of Science Citations: 0.
NERY, ANDREIA FERREIRA; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS; PORTELA, TIAGO FERREIRA; HOFFMANN-SANTOS, HUGO DIAS; PINHEIRO, BRENO GONCALVES; POSSA, ANA PAULA; DA SILVA CAVALCANTE, LETICIA ROSSETTO; HAGEN, FERRY; HAHN, ROSANE CHRISTINE. Puzzling paracoccidioidomycosis: Factors associated with the severity of Paracoccidioides lutzii infections. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v. 107, p. 284-290, JUN 2021. Web of Science Citations: 0.
PINHEIRO, BRENO GONCALVES; POSSA, ANA PAULA; DELLA TERRA, PAULA PORTELLA; DE CARVALHO, JAMILE AMBROSIO; RICCI, GIANNINA; NISHIKAKU, ANGELA SATIE; HAHN, ROSANE CHRISTINE; CAMARGO, ZOILO PIRES DE; RODRIGUES, ANDERSON MESSIAS. A New Duplex PCR-Assay for the Detection and Identification of Paracoccidioides Species. JOURNAL OF FUNGI, v. 7, n. 3 MAR 2021. Web of Science Citations: 0.
PECANHA, PAULO MENDES; BAHIENSE, ISABELA CRUZ; LIMA KRUSCHEWSKY, WDSON LUIS; BIASUTTI, CLAUDIA; GONCALVES FERREIRA JUNIOR, CARLOS URBANO; PINHEIRO, BRENO GONCALVES; MAIFREDE, SIMONE BRAVIM; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS; GRAO-VELLOSO, TANIA REGINA; FALQUETO, ALOISIO; GONCALVES, SARAH SANTOS. Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report. REVISTA IBEROAMERICANA DE MICOLOGIA, v. 38, n. 1, p. 5-8, JAN-MAR 2021. Web of Science Citations: 1.
BAHIENSE ROCHA, ISABELA DA CRUZ; DELLA TERRA, PAULA PORTELLA; DE OLIVEIRA, RODRIGO CARDOSO; ZANOTTI, RAPHAEL LUBIANCA; FALQUETO, ALOISIO; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS; GONCALVES, SARAH SANTOS. Molecular-based assessment of diversity and population structure of Sporothrix spp. clinical isolates from Espirito Santo-Brazil. MYCOSES, v. 64, n. 4 DEC 2020. Web of Science Citations: 0.
PINHEIRO, BRENO GONCALVES; HAHN, ROSANE CHRISTINE; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS. Molecular Tools for Detection and Identification of Paracoccidioides Species: Current Status and Future Perspectives. JOURNAL OF FUNGI, v. 6, n. 4 DEC 2020. Web of Science Citations: 1.
RODRIGUES, ANDERSON MESSIAS; KUBITSCHEK-BARREIRA, PAULA HELENA; PINHEIRO, BRENO GONCALVES; TEIXEIRA-FERREIRA, ANDRE; HAHN, ROSANE CHRISTINE; DE CAMARGO, ZOILO PIRES. Immunoproteomic Analysis Reveals Novel Candidate Antigens for the Diagnosis of Paracoccidioidomycosis Due to Paracoccidioides lutzii. JOURNAL OF FUNGI, v. 6, n. 4 DEC 2020. Web of Science Citations: 0.
RODRIGUES, A. M.; BEALE, M. A.; HAGEN, F.; FISHER, M. C.; TERRA, P. P. D.; DE HOOG, S.; BRILHANTE, R. S. N.; DE AGUIAR CORDEIRO, R.; DE SOUZA COLLARES MAIA CASTELO-BRANCO, D.; ROCHA, M. F. G.; SIDRIM, J. J. C.; DE CAMARGO, Z. P. The global epidemiology of emerging Histoplasma species in recent years. STUDIES IN MYCOLOGY, n. 97 SEP 2020. Web of Science Citations: 5.
DE CARVALHO, JAMILE AMBROSIO; HAGEN, FERRY; FISHER, MATTHEW C.; DE CAMARGO, ZOILO PIRES; RODRIGUES, ANDERSON MESSIAS. Genome-wide mapping using new AFLP markers to explore intraspecific variation among pathogenicSporothrixspecies. PLoS Neglected Tropical Diseases, v. 14, n. 7 JUL 2020. Web of Science Citations: 0.
MACEDO-SALES, PAMELLA ANTUNES; PEREIRA SOUZA, LUCIERI OLEGARIO; DELLA-TERRA, PAULA PORTELLA; LOZOYA-PEREZ, NANCY EDITH; DANTAS MACHADO, RICARDO LUIZ; DA SILVA DA ROCHA, ELISABETH MARTINS; LOPES-BEZERRA, LEILA MARIA; GUIMARAES, ALLAN JEFFERSON; RODRIGUES, ANDERSON MESSIAS; MANUEL MORA-MONTES, HECTOR; SOUZA DOS SANTOS, ANDRE LUIS; DE SOUZA BAPTISTA, ANDREA REGINA. Coinfection of domestic felines by distinct Sporothrix brasiliensis in the Brazilian sporotrichosis hyperendemic area. Fungal Genetics and Biology, v. 140, JUL 2020. Web of Science Citations: 2.
ALVES, MANOELLA DO MONTE; MILAN, EVELINE PIPOLO; DA SILVA-ROCHA, WALICYRANISON PLINIO; DE SENA DA COSTA, ALEXANDRE SOARES; MACIELID, BRUNO ARAUJO; CAVALCANTE VALE, PEDRO HENRIQUE; DE ALBUQUERQUE, PAULO ROBERTO; LIMA, SORAIA LOPES; DE AZEVEDO MELO, ANALY SALLES; RODRIGUES, ANDERSON MESSIAS; CHAVES, GUILHERME MARANHAO. Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil. PLoS Neglected Tropical Diseases, v. 14, n. 5 MAY 2020. Web of Science Citations: 0.
RODRIGUES, ANDERSON MESSIAS; DELLA TERRA, PAULA PORTELLA; GREMIAO, ISABELLA DIB; PEREIRA, SANDRO ANTONIO; OROFINO-COSTA, ROSANE; DE CAMARGO, ZOILO PIRES. The threat of emerging and re-emerging pathogenic Sporothrix species. Mycopathologia, v. 185, n. 5, SI FEB 2020. Web of Science Citations: 10.
DO AMARAL, CRISTIANE CANDIDA; FERNANDES, GEISA FERREIRA; RODRIGUES, ANDERSON MESSIAS; BURGER, EVA; DE CAMARGO, ZOILO PIRES. Proteomic analysis of Paracoccidioides brasiliensis complex isolates: Correlation of the levels of differentially expressed proteins with in vivo virulence. PLoS One, v. 14, n. 7 JUL 2 2019. Web of Science Citations: 0.
HAHN, ROSANE CHRISTINE; RODRIGUES, ANDERSON MESSIAS; DELLA TERRA, PAULA PORTELLA; NERY, ANDREIA FERREIRA; HOFFMANN-SANTOS, HUGO DIAS; GOIS, HELLEN MEIRA; FERNANDES FONTES, COR JESUS; DE CAMARGO, ZOILO PIRES. Clinical and epidemiological features of paracoccidioidomycosis due to Paracoccidioides lutzii. PLoS Neglected Tropical Diseases, v. 13, n. 6 JUN 2019. Web of Science Citations: 3.

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