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Selective aromatic functionalization: Methodological Studies and new applications in the synthesis of BIOATIVE compounds

Abstract

In the present project we intend to study the potential of organometallic reagents in the development of methodologies for selective functionalization of aromatic and heterocyclic substrates of great scientific and technological interest, mainly for Medicinal Chemistry. In this sense, directed metalation or halogen/metal exchange reactions in a series of aryl nitriles, quinolines, indolizines and quinoxalines, among other targets that may be of interest in the course of the project should allow the isolation of new highly functionalized aromatic and heterocyclic compounds. With the aim to better understand, rationalize and plan regioselective metalation reactions, computational chemistry tools will be used in the structural evaluation of all synthetic targets. Finally, in order to demonstrate the synthetic importance of the developed methodologies, applications in the preparation or structural modification of substances of medicinal interest, such as quinazolines and quinolines with potential antitumor activity, will be carried out. (AU)

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Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, RAFAELY N.; DE L. L. VAZ, ARTUR; CLOSOSKI, GIULIANO C.; PORTO, ANDRE L. M.. Sustainable Synthesis of Amides from Ethyl 3-(4-Hydroxyphenyl) Propionate. CHEMISTRYSELECT, v. 6, n. 13, p. 3271-3276, . (14/18257-0, 18/14150-8, 16/12718-1)
NISHIMURA, RODOLFO H. V.; VAZ, ARTUR DE L. L.; BOZZINI, LEANDRO A.; MURIE, VALTER E.; CLOSOSKI, GIULIANO C.. Recent applications of magnesium- and Zinc-TMP amides in the synthesis of bioactive targets. Tetrahedron, v. 75, n. 4, p. 464-474, . (16/12718-1, 15/21364-6, 15/01466-9, 18/14150-8)
DE MELLO, MURILO B. M.; DE OLIVEIRA, ANTONIO A. F.; DE OLIVEIRA, CAROLINE L.; ULTRAMARI, MARIAH A.; GAETA, FERNANDO H. S.; MASCARELLO, ALESSANDRA; GUIMARAES, CRISTIANO R. W.; DE FREITAS, MILLER N.; CUNHA, CARLOS E.; LOURENCO, TIAGO C.; et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. Journal of the Brazilian Chemical Society, v. 30, n. 7, p. 1415-1424, . (18/14150-8, 15/12811-9, 14/50265-3)
DOS SANTOS, THIAGO; ORENHA, HENRIQUE P.; MURIE, VALTER E.; VESSECCHI, RICARDO; CLOSOSKI, GIULIANO C.. Selective Metalation and Functionalization of Fluorinated Nitriles Using 2,2,6,6-Tetramethylpiperidyl Bases. ORGANIC LETTERS, v. 23, n. 19, p. 7396-7400, . (15/21364-6, 18/14150-8, 15/01017-0)
PORTAPILLA, GISELE BULHOES; PEREIRA, LUIZ MIGUEL; SOLDI, RAFAEL AUGUSTO; ABREU FILHO, PERICLES GAMA; GALLO, INARA FERNANDA LAGE; CLOSOSKI, GIULIANO CESAR; DE ALBUQUERQUE, SERGIO. Activity of beta-Caryophyllene Oxide Derivatives Against Trypanosoma cruzi, Mammalian Cells, and Horseradish Peroxidase. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 30, n. 6, . (12/02105-1, 12/16168-5, 18/14150-8)
NISHIMURA, V, RODOLFO H.; DOS SANTOS, THIAGO; MURIE, VALTER E.; FURTADO, LUCIANA C.; COSTA-LOTUFO, V, LETICIA; CLOSOSKI, GIULIANO C.. Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents. Beilstein Journal of Organic Chemistry, v. 17, p. 2968-2975, . (15/17177-6, 17/18235-5, 15/21364-6, 18/14150-8, 20/08987-2, 15/01466-9)
CLOSOSKI, GIULIANO C.; SOLDI, RAFAEL A.; DA SILVA, RODRIGO M.; GUARATINI, THAIS; LOPES, JOSE N. C.; PEREIRA, PAMELA R. R.; LOPES, JOAO L. C.; DOS SANTOS, THIAGO; MARTINS, RONALDO B.; COSTA, CRISTINA S.; et al. Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vitro Biological Results for SARS-CoV-2. Journal of the Brazilian Chemical Society, v. 31, n. 8, p. 1552-1556, . (14/50265-3, 18/14150-8, 14/02438-6)
BERTALLO, CAMILA R. S.; BERLIM, LEONARDO S.; OLIVIER, DANILO S.; ARROIO, THAIS R.; ITO, AMANDO S.; CLOSOSKI, GIULIANO C.. Synthesis and photophysical properties of 2-aryl-5-carbonyl indolizines. DYES AND PIGMENTS, v. 198, . (18/14150-8, 15/03007-1, 18/02855-7, 20/13962-9)
BOZZINI, LEANDRO A.; DOS SANTOS, THIAGO; MURIE, VALTER E.; DE MELLO, MURILO B. M.; VESSECCHI, RICARDO; CLOSOSKI, GIULIANO C.. Regioselective Functionalization of Ester-, Amide-, Carbonate-, and Carbamate-Substituted 2-Phenyl-2-oxazolines with Mixed Lithium-Magnesium Amides. Journal of Organic Chemistry, v. 86, n. 1, p. 1204-1215, . (18/14150-8, 15/21364-6, 14/23604-1)
DARTAGNAN S. P. FERREIRA; VALTER E. MURIE; THIAGO DOS SANTOS; PAULO C. VIEIRA; GIULIANO C. CLOSOSKI. Recentes avanços na funcionalização seletiva de quinolinas. Química Nova, v. 44, n. 5, p. 599-615, . (19/05838-9, 15/21364-6, 18/14150-8)
DOS SANTOS, THIAGO; GRUNDKE, CAROLINE; LUCAS, TOBIAS; GROSSMANN, LUCA; CLOSOSKI, GIULIANO CESAR; OPATZ, TILL. Glucose as an Eco-Friendly Reductant in a One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2020, n. 41, . (18/14150-8)
MURIE, VALTER E.; NICOLINO, V, PAULA; DOS SANTOS, THIAGO; GAMBACORTA, GUIDO; NISHIMURA, V, RODOLFO H.; PEROVANI, ICARO S.; FURTADO, LUCIANA C.; COSTA-LOTUFO, V, LETICIA; DE OLIVEIRA, ANDERSON MORAES; VESSECCHI, RICARDO; et al. Synthesis of 7-Chloroquinoline Derivatives Using Mixed Lithium-Magnesium Reagents. Journal of Organic Chemistry, v. 86, n. 19, p. 13402-13419, . (13/00758-0, 15/21364-6, 19/05838-9, 18/14150-8, 15/17177-6)

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