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Scientific, technological and infrastructure qualification in radiopharmaceuticals, radiation and entrepreneurship for health purposes (PDIp)

Grant number: 17/50332-0
Support Opportunities:Research Grants - State Research Institutes Modernization Program
Duration: April 01, 2018 - March 31, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Marcelo Linardi
Grantee:Marcelo Linardi
Host Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil
Pesquisadores principais:
Ademar Benévolo Lugão ; Artur Wilson Carbonari ; Elaine Bortoleti de Araújo ; Maria Elisa Chuery Martins Rostelato ; Monica Beatriz Mathor ; Niklaus Ursus Wetter ; Nilson Dias Vieira Junior
Associated grant(s):18/25754-1 - Multi user equipment approved in grant FAPESP 2017/50332-0: digital mammograph, AP.EMU
19/24085-1 - Development and characterization of nanoparticulate biomaterials for therapeutic and diagnostic applications in medicine, AV.EXT
19/17154-7 - Development and characterization of nanoparticulated biomaterials for medicine therapy and diagnostic applications, AV.EXT
+ associated grants 18/25961-7 - Laser particle acceleration and applications, AP.R SPRINT
18/19251-7 - Multi-User Equipment approved in grant 2017/50332-0: ASAP 2020 plus surface area analyzer, volume and pore area, AP.EMU
18/19240-5 - Multi-user equipment approved in grant 2017-50332-0: STM-AFM Raman SNOM analysis system, AP.EMU - associated grants
Associated scholarship(s):22/07199-6 - Characterization of nanocomposites and their interaction with cellular tissue by SNOM techniques for the purpose of new drugs, BP.PD
21/13737-8 - Acceleration of laser particles in the Scientific, Technological and Infrastructure Training program in Radiopharmaceuticals and Entrepreneurship at the Service of Health., BP.PD
19/15154-0 - Smart immunotherapeutic gold and palladium nanoparticles functionalized with immunomodulatory phytochemicals (mangiferin, resveratrol, piceatanol, naringin, silibilin, and astringin) and their use as radiosensitizers for tumor ablation therapy, BP.PD
+ associated scholarships 19/15620-0 - Tuning MFe2O4 (M=Co,Ni) nanoparticles for in vivo biomedical applications: Doping with rare earths and biocompatible coating, BP.PD
19/15640-1 - The role of Tissue Engineering on the development of in vitro models for biocompatibility tests and biological assessment, BP.PD
18/18526-2 - Radioactive Nanosource for Use in Brachytherapy, BP.PD
19/10110-4 - Studies of adequacy of radiolabeling of PSMA-1007 with fluorine-18 : validation of the analytical methodology and pre-clinical evaluation in the diagnosis of prostate cancer, BP.MS
19/04172-7 - Pharmacotechnical development of DOTATATO lyophilized kit for 68Ga labeling and preclinical evaluation, BP.DR
18/18928-3 - Development and Application of Theranostic Biomaterials: Evaluation of Cellular Response to Fluorescent Nanoparticles of Lanthanide and Magnesium-doped Calcium Phosphates and its Applicability as Non-Viral Vectors for Gene Therapy, BE.PQ
18/13096-0 - Study for implantation of the radiopharmaceutical FES-18F process production in an automated system: process validation and analytical methods approach, BP.MS
18/12965-4 - Obtaining and evaluating the applicability in the treatment of Prostate Cancer of the PSMA-617 kit for prompt radiolabeling with lutetium-177, BP.DR - associated scholarships

Abstract

The Scientific and Technological Qualification refers to the necessary adaptation to the development of new radiopharmaceuticals, specifically in the phase of scheduling until pilot, within the required quality standards. In addition, one must consider safety issues for manipulation of high radioactive activities, compatible with the scale of industrial production, making it possible to close development cycle for new products, destined to conduct clinical studies in order to demonstrate their efficacy and safety. In addition, this capacitation includes the development of advanced laboratory practices for the chemical and isotopic qualification of radiopharmaceuticals and nanobiomaterials, for health application, via mass spectrometry technique, among others. Radiopharmaceuticals produced at IPEN need assessment by pre-clinical tests for ANVISA approval. This project also aims to carry out research to evaluate the cytotoxic and genotoxic activity of new radiopharmaceutical candidates, as well as to improve radiation detection systems and the processes associated with radiotherapy, nuclear medicine and radio diagnosis, using high performance computing. Considering the qualification in R&D Infrastructure, the project aims to create a nucleus of imaging studies in molecules, cells, tissues and nanoparticles associated to biological processes at IPEN, unprecedented in the country, by SNOM and micro-FTIR, for innovative use in medicine. The proposed techniques will allow mapping of ultrastructural and cellular changes before and after a given treatment, by either laser, nanoparticules, brachytherapy, or radiopharmaceutical. On another front of R&D, the objective is to demonstrate the feasibility of the acceleration of charged particles (electrons/protons/hadrons) in compact systems with lower cost, compared to conventional technologies of acceleration, aiming to proton therapy for nuclear medicine. Closing the virtuous cycle of Innovation and Entrepreneurship, the project aims to improve the management of knowledge and intellectual property generated at IPEN and its interface with the productive sector, in specific actions. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Radiofármacos en peligro 
Radiopharmaceuticals under threat 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (44)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZANINI, NATHALIA A.; RABELO, THAIS F.; ZAMATARO, CLAUDIA B.; CARAMEL-JUVINO, AMANDA; ANA, PATRICIA A.; ZEZELL, DENISE M.. Morphological, optical, and elemental analysis of dental enamel after debonding laminate veneer with Er,Cr:YSGGlaser: A pilot study. MICROSCOPY RESEARCH AND TECHNIQUE, v. 84, n. 3, p. 489-498, . (17/50332-0, 05/51689-2)
VILLANI, D.; RODRIGUES, JR., O.; CAMPOS, L. L.. Dosimetric characterization of 3D printed phantoms at different infill percentages for diagnostic X-ray energy range. Radiation Physics and Chemistry, v. 172, . (17/50332-0)
LOPES, MNICA SCHAFFER; PEREIRA, DAISA LIMA; BRAINER DE OLIVEIRA MOTA, CLAUDIA CRISTINA; AMARAL, MARCELLO MAGRI; ZEZELL, DENISE MARIA; LEONIDAS GOMES, ANDERSON STEVENS. The lingual enamel morphology and bracket shear bond strength influenced by Nd:YAG laser and aluminum oxide sandblasting preconditioning. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 3, . (17/50332-0, 05/51689-2)
VINÍCIUS MAXIMIANO; ALANA CRISTINA MACHADO; RAQUEL MARIANNA LOPES; FERNANDA ELLEN MERCATELLI RABELO; STEPHANIE ASSIMAKOPOULOS GARÓFALO; DENISE MARIA ZEZELL; ANA CECILIA CORRÊA ARANHA; TAÍS SCARAMUCCI. Association of Nd:YAG laser and calcium-phosphate desensitizing pastes on dentin permeability and tubule occlusion. Journal of Applied Oral Science, v. 29, . (17/02341-0, 17/24714-3, 17/50332-0)
DEL VALLE, MATHEUS; STANCARI, KLEBER; AUGUSTO DE CASTRO, PEDRO ARTHUR; DOS SANTOS, MOISES OLIVEIRA; ZEZELL, DENISE MARIA; IEEE. Machine Learning methods for micro-FTIR imaging classification of human skin tumors. 2021 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC), v. N/A, p. 5-pg., . (13/26113-6, 17/50332-0, 05/51689-2)
BORDON, CAMILA D. S.; DIPOLD, JESSICA; FREITAS, ANDERSON Z.; WETTER, NIKLAUS U.; DE ROSSI, WAGNER; KASSAB, LUCIANA R. P.. A new double-line waveguide architecture for photonic applications using fs laser writing in Nd3+ doped GeO2-PbO glasses. Optical Materials, v. 129, p. 6-pg., . (13/26113-6, 17/50332-0, 18/19240-5, 16/02326-9, 17/10765-5, 19/06334-4)
FAROOQ, SAJID; GERMANO, GLEICE; STANCARI, KLEBER ADRIANI; RAFFAELI, ROCIO; CROCE, MARIA VIRGINIA; CROCE, ADELA E.; ZEZELL, DENISE MARIA; IEEE. A 3D discriminant analysis for Hyperspectral FTIR images. 2023 INTERNATIONAL CONFERENCE ON OPTICAL MEMS AND NANOPHOTONICS, OMN AND SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, SBFOTON IOPC, v. N/A, p. 2-pg., . (21/00633-0, 17/50332-0)
PERES, DANIELLA LUMARA; FAROOQ, SAJID; RAFFAELI, ROCIO; CROCE, MARIA VIRGINIA; CROCE, ADELA E.; ZEZELL, DENISE MARIA; IEEE. Identification of basal cell carcinoma skin cancer using FTIR and Machine learning. 2023 INTERNATIONAL CONFERENCE ON OPTICAL MEMS AND NANOPHOTONICS, OMN AND SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, SBFOTON IOPC, v. N/A, p. 2-pg., . (21/00633-0, 17/50332-0)
FAROOQ, SAJID; PERES, DANIELLA L. PRIME UMARA; CAIXETA, DOUGLAS CARVALHO; LIMA, CASSIO; DA SILVA, ROBINSON SABINO; ZEZELL, DENISE MARIA; IEEE. Monitoring changes in urine from diabetic rats using ATR-FTIR and Machine Learning. 2023 INTERNATIONAL CONFERENCE ON OPTICAL MEMS AND NANOPHOTONICS, OMN AND SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, SBFOTON IOPC, v. N/A, p. 2-pg., . (21/00633-0, 17/50332-0)
CORREA, BRUNO S.; COSTA, MESSIAS S.; CABRERA-PASCA, GABRIEL A.; SENA, CLEIDILANE; PINTO, RAFAEL H.; SILVA, ANA PAULA S.; CARVALHO JUNIOR, RAUL N.; ISHIDA, LINA; RAMON, JONATHAN G. A.; FREITAS, RAFAEL S.; et al. High-saturation magnetization in small nanoparticles of Fe3O4 coated with natural oils. JOURNAL OF NANOPARTICLE RESEARCH, v. 22, n. 3, . (15/16191-5, 17/50332-0)
SANTOS, V, RENATA; CABRERA-PASCA, GABRIEL A.; COSTA, CLEIDILANE S.; BOSCH-SANTOS, BRIANNA; OTUBO, LARISSA; PEREIRA, LUCIANO F. D.; CORREA, BRUNO S.; EFFENBERGER, FERNANDO B.; BURIMOVA, ANASTASIA; FREITAS, RAFAEL S.; et al. Crystalline and magnetic properties of CoO nanoparticles locally investigated by using radioactive indium tracer. SCIENTIFIC REPORTS, v. 11, n. 1, . (19/15620-0, 17/50332-0, 15/16191-5)
ANDRADE, MAIRA FRANCO; SARDO, ARIANE VENZON NAIA; BENETTI, CAROLINA; SICCHIERI, LETICIA BONFANTE; CORREA, LUCIANA; ZEZELL, DENISE MARIA. Comparison of Two Light Wavelengths (lambda = 660 nm and lambda = 780 nm) in the Repair Process of Oral Mucositis Induced by Ionizing Radiation: Clinical and Microscopic Evaluations in Rats. PHOTONICS, v. 10, n. 1, p. 13-pg., . (17/07519-2, 17/50332-0, 13/26113-6)
SILVA, FELIPE D.; OLIVEIRA, JOAO E.; FREIRE, RENAN P.; SUZUKI, MIRIAM F.; SOARES, CARLOS R.; BARTOLINI, PAOLO. Expression of glycosylated human prolactin in HEK293 cells and related N-glycan composition analysis. AMB EXPRESS, v. 9, n. 1, . (15/26058-0, 17/50332-0)
RODRIGUES, PRISCILA S.; BURIMOVA, ANASTASIA; SALES, TATIANE S. N.; FILHO, ARNALDO A. M.; OTUBO, LARISSA; SAXENA, RAJENDRA N.; CARBONARI, ARTUR W.. The effect of Er doping on local structure of magnetite nanoparticles. HYPERFINE INTERACTIONS, v. 242, n. 1, p. 6-pg., . (19/15620-0, 17/50332-0)
DE LIMA, CAROLINE S. A.; VARCA, JUSTINE P. R. O.; ALVES, VICTORIA M.; NOGUEIRA, KAMILA M.; CRUZ, CASSIA P. C.; RIAL-HERMIDA, M. ISABEL; KADLUBOWSKI, SLAWOMIR S.; VARCA, GUSTAVO H. C.; LUGAO, ADEMAR B.. Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer. GELS, v. 8, n. 9, p. 25-pg., . (17/50332-0)
SARDO, ARIANE VENZON NAIA; ANDRADE, MAIRA FRANCO; FIGUEIREDO, ANAELIZA; ROSIN, FLAVIA CRISTINA PERILLO; CORREA, LUCIANA; ZEZELL, DENISE MARIA. Does Photobiomodulation Affects CK10 and CK14 in Oral Mucositis Radioinduced Repair?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 24, p. 9-pg., . (21/00633-0, 17/50332-0, 13/26113-6)
DEL VALLE, MATHEUS; DOS SANTOS, MOISES OLIVEIRA; DOS SANTOS, SOFIA NASCIMENTO; BERNARDES, EMERSON SOARES; ZEZELL, DENISE MARIA; IEEE. Evaluation of machine learning models for the classification of breast cancer hormone receptors using micro-FTIR images. 2021 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC), v. N/A, p. 3-pg., . (05/51689-2, 17/50332-0)
MALDONADO, EDISON PUIG; SAMAD, RICARDO ELGUL; ZUFFI, ARMANDO VALTER FELICIO; VIEIRA JR, NILSON DIAS. Simulation of self-modulated laser wakefield acceleration using few TW in downramp injection and ionization injection regimes. APPLIED OPTICS, v. 62, n. 12, p. 6-pg., . (18/25961-7, 17/50332-0)
AMARAL, MARCELLO M.; ZEZELL, DENISE M.; MONTE, ADAMO F. G.; DE CARA, ANA C. B.; ARAUJO, JEANN C. R.; ANTUNES, ANDREA; FREITAS, ANDERSON Z.. General model for depth-resolved estimation of the optical attenuation coefficients in optical coherence tomography. Journal of Biophotonics, v. 12, n. 10, . (10/03123-8, 17/50332-0, 05/51689-2)
SAVI, MATHEUS; ANDRADE, MARCO A. B.; POTIENS, MARIA P. A.. Commercial filament testing for use in 3D printed phantoms. Radiation Physics and Chemistry, v. 174, . (17/50332-0)
DIAS-MORAES, MARCIA CRISTINA; CASTRO, PEDRO ARTHUR AUGUSTO; PEREIRA, DAISA LIMA; ANA, PATRICIA APARECIDA; FREITAS, ANDERSON ZANARDI; ZEZELL, DENISE MARIA. Assessment of the preventive effects of Nd:YAG laser associated with fluoride on enamel caries using optical coherence tomography and FTIR spectroscopy. PLoS One, v. 16, n. 7, . (17/50332-0, 05/51689-2)
DARUICH DE SOUZA, CARLA; BUENO BARBEZAN, ANGELICA; ARCOS ROSERO, WILMMER ALEXANDER; NASCIMENTO DOS SANTOS, SOFIA; VERGACAS DE SOUSA CARVALHO, DIEGO; ZEITUNI, CARLOS ALBERTO; SOARES BERNARDES, EMERSON; PEREZ VIEIRA, DANIEL; SPENCER, PATRICK JACK; SIMOES RIBEIRO, MARTHA; et al. ynthesis, In Vitro Testing, and Biodistribution of Surfactant-Free Radioactive Nanoparticles for Cancer Treatmen. NANOMATERIALS, v. 12, n. 2, . (18/18526-2, 17/50332-0)
AUGUSTO DE CASTRO, PEDRO ARTHUR; DIAS, DERLY AUGUSTO; DEL-VALLE, MATHEUS; VELOSO, MARCELO NORONHA; RIBEIRO SOMESSARI, ELIZABETH SEBASTIANA; ZEZELL, DENISE MARIA. Assessment of bone dose response using ATR-FTIR spectroscopy: A potential method for biodosimetry. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 273, p. 7-pg., . (21/00633-0, 17/50332-0)
DOS SANTOS, JHONATHA RICARDO; BUENO, PATRICIA; JAKUTIS, JONAS; VICTOR, ALESSANDRO R.; BARRETA, LUIZ F. N.; SBAMPATO, MARIA ESTHER; NERI, JOST W.; SILVEIRA, CARLOS A. B.; RODRIGUES, NICOLAU A. S.; DESTRO, MARCELO GERALDO. Dysprosium optogalvanic spectroscopy in a hollow cathode lamp. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, v. 40, n. 5, p. 7-pg., . (21/13737-8, 17/50332-0)
BOSCH-SANTOS, B.; NASCIMENTO, N. M.; SAIKI, M.; CORREA, E. L.; SALES, T. S. N.; PEREIRA, L. F. D.; CABRERA-PASCA, G. A.; SAXENA, R. N.; SCHELL, J.; CARBONARI, A. W.. Magnetic field at Ce impurities in La sites of La0.5Ba0.5MnO3 double perovskites. AIP ADVANCES, v. 9, n. 3, . (17/50332-0)
CORREA, E. L.; BOSCH-SANTOS, B.; SAXENA, R. N.; CABRERA-PASCA, G. A.; CARBONARI, A. W.. Effects of an external magnetic field on the hyperfine parameters in RE2O3 (RE = Gd, Er) nanoparticles measured by perturbed angular correlation spectroscopy. AIP ADVANCES, v. 10, n. 1, . (17/50332-0)
JUVINO, AMANDA CARAMEL; ROMANO, MARIANA; ALVES, NATHALIA ZANINI; FREITAS, THAIS RABELO; ZAMATARO, CLAUDIA BIANCHI; ZEZELL, DENISE MARIA; IEEE. Evaluation of the anti-caries effect beyond the critical enamel pH of preventive treatment of fluoride associated with Nd:YAG laser irradiation. 2021 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC), v. N/A, p. 4-pg., . (13/26113-6, 17/50332-0, 05/51689-2)
MALDONADO, EDISON PUIG; SAMAD, RICARDO ELGUL; ZUFFI, ARMANDO VALTER FELICIO; DOS SANTOS, JHONATHA RICARDO; VIEIRA JUNIOR, NILSON DIAS. Impact of He+N2 concentration on self-modulated laser wakefield acceleration driven by pulses of a few TW. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, v. 40, n. 4, p. 7-pg., . (18/25961-7, 17/50332-0, 21/13737-8)
SUZUKI, MIRIAM F.; ALMEIDA, LARISSA A.; POMIN, STEPHANIE A.; SILVA, FELIPE D.; FREIRE, RENAN P.; OLIVEIRA, JOAO E.; AFFONSO, REGINA; SOARES, CARLOS R. J.; BARTOLINI, PAOLO. Periplasmic synthesis and purification of the human prolactin antagonist Delta(1-11)-G129R-hPRL. AMB EXPRESS, v. 11, n. 1, . (12/24345-4, 17/50332-0, 15/26058-0)
CAMPOS, ALEX C.; PAES, SUANE C.; CORREA, BRUNO S.; CABRERA-PASCA, GABRIEL A.; COSTA, MESSIAS S.; COSTA, CLEIDILANE S.; OTUBO, LARISSA; CARBONARI, A. W.. Growth of Long ZnO Nanowires with High Density on the ZnO Surface for Gas Sensors. ACS APPLIED NANO MATERIALS, v. 3, n. 1, p. 175-185, . (17/50332-0)
SALES, T. S. N.; BURIMOVA, A.; RODRIGUES, P. S.; MATOS, I. T.; CABRERA-PASCA, G. A.; SAXENA, R. N.; PEREIRA, L. F. D.; OTUBO, L.; CARBONARI, A. W.. Synthesis and characterization of Fe3O4-HfO2 nanoparticles by hyperfine interactions measurements. AIP ADVANCES, v. 11, n. 1, . (19/15620-0, 17/50332-0)
BURIMOVA, ANASTASIA; CARBONARI, ARTUR WILSON; DE LIMA, NICOLE PEREIRA; MIRANDA FILHO, ARNALDO ALVES; DOS SANTOS SOUZA, ALEXANDRE PINHO; NASCIMENTO SALES, TATIANE DA SILVA; FERREIRA, WANDERSON LOBATO; DIAS PEREIRA, LUCIANO FABRICIO; CORREA, BRUNO SANTOS; SAXENA, RAJENDRA NARAIN. Local Crystalline Structure of Doped Semiconductor Oxides Characterized by Perturbed Angular Correlations: Experimental and Theoretical Insights. CRYSTALS, v. 12, n. 9, p. 15-pg., . (18/18657-0, 19/15620-0, 17/50332-0)
DE LIMA, CAROLINE S. A.; RIAL-HERMIDA, M. ISABEL; DE FREITAS, LUCAS FREITAS; PEREIRA-DA-MOTA, ANA F.; VIVERO-LOPEZ, MARIA; FERREIRA, ARYEL HEITOR; KADLUBOWSKI, SLAWOMIR; VARCA, GUSTAVO H. C.; LUGAO, ADEMAR B.; ALVAREZ-LORENZO, CARMEN. Mucoadhesive gellan gum-based and carboxymethyl cellulose-based hydrogels containing gemcitabine and papain for bladder cancer treatment. International Journal of Biological Macromolecules, v. 242, p. 16-pg., . (17/50332-0)
BORDON, CAMILA DIAS DA SILVA; DIPOLD, JESSICA; WETTER, NIKLAUS U. U.; DE ROSSI, WAGNER; FREITAS, ANDERSON Z. Z.; KASSAB, LUCIANA R. P.. Effect of Silver Nanoparticles on the Optical Properties of Double Line Waveguides Written by fs Laser in Nd3+-Doped GeO2-PbO Glasses. NANOMATERIALS, v. 13, n. 4, p. 13-pg., . (18/19240-5, 13/26113-6, 17/50332-0, 16/02326-9, 17/10765-5, 19/06334-4)
CARAMEL-JUVINO, AMANDA; FAROOQ, SAJID; ROMANO, MARIANA; ZEZELL, DENISE MARIA; IEEE. Identification of enamel demineralization using high performance convolutional neural network. 2022 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC), v. N/A, p. 3-pg., . (17/50332-0)
FAROOQ, SAJID; CARAMEL-JUVINO, AMANDA; DEL-VALLE, MATHEUS; SANTOS, SOFIA; BERNANDES, EMERSON SOARES; ZEZELL, DENISE MARIA; IEEE. Superior Machine Learning Method for breast cancer cell lines identification. 2022 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC), v. N/A, p. 3-pg., . (17/50332-0)
ZUFFI, ARMANDO V. F.; TABACOW, FABIO B. D.; VIEIRA, NILSON D.; SAMAD, RICARDO E.; IEEE. Ultrafast laser micromachining of submillimetric de Laval nozzles in alumina for laser electron acceleration. 2022 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC), v. N/A, p. 5-pg., . (18/25961-7, 17/50332-0)
ZUFFI, ARMANDO VALTER FELICIO; DOS SANTOS, JHONATHA RICARDO; MALDONADO, EDISON PUIG; VIEIRA JR, NILSON DIAS; SAMAD, RICARDO ELGUL. Femtosecond laser-plasma dynamics study by a time-resolved Mach-Zehnder-like interferometer. APPLIED OPTICS, v. 62, n. 8, p. 7-pg., . (17/50332-0, 21/13737-8)
FAROOQ, SAJID; DEL-VALLE, MATHEUS; DOS SANTOS, MOISES OLIVEIRA; DOS SANTOS, SOFIA NASCIMENTO; BERNARDES, EMERSON SOARES; ZEZELL, DENISE MARIA. Rapid identification of breast cancer subtypes using micro-FTIR and machine learning methods. APPLIED OPTICS, v. 62, n. 8, p. 8-pg., . (21/00633-0, 17/50332-0)
CASTRO, PEDRO A. A.; LIMA, CASSIO A.; MORAIS, MYCHEL R. P. T.; ZORN, TELMA M. T.; ZEZELL, DENISE M.. Monitoring the Progress and Healing Status of Burn Wounds Using Infrared Spectroscopy. Applied Spectroscopy, v. 74, n. 7, . (13/26113-6, 17/50332-0, 05/51689-2)
JALILIAN, AMIR R.; OCAMPO-GARCIA, BLANCA; PASANPHAN, WANVIMOL; SAKR, TAMER M.; MELENDEZ-ALAFORT, LAURA; GRASSELLI, MARIANO; LUGAO, ADEMAR B.; YOUSEFNIA, HASSAN; DISPENZA, CLELIA; JANIB, SITI MOHD; et al. IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery. PHARMACEUTICS, v. 14, n. 5, p. 26-pg., . (17/50332-0)
DEL-VALLE, MATHEUS; SANTOS, MOISES OLIVEIRA DOS; SANTOS, SOFIA NASCIMENTO DOS; CASTRO, PEDRO ARTHUR AUGUSTO DE; BERNARDES, EMERSON SOARES; ZEZELL, DENISE MARIA. The impact of scan number and its preprocessing in micro-FTIR imaging when applying machine learning for breast cancer subtypes classification. VIBRATIONAL SPECTROSCOPY, v. 117, . (17/50332-0)
SAVI, M.; VILLANI, D.; ANDRADE, M. A. B.; RODRIGUES JR, O.; POTIENS, M. P. A.. Study on attenuation of 3D printing commercial filaments on standard X-ray beams for dosimetry and tissue equivalence. Radiation Physics and Chemistry, v. 182, p. 7-pg., . (17/50332-0)

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