Advanced search
Start date
Betweenand

Exploring turmeric curcuminoids to treat schistosomiasis: an evaluation of their pre-clinical potential

Abstract

The project emerged from a discussion between L. Caldas and C. Caffrey during the visit of Profa. Caldas in August 2016 to the Center for Discovery and Innovation in Parasitic Diseases (www.cdipd.org) at the University of California San Diego where Prof. Caffrey is a senior center director. During this visit, both PIs agreed to collaborate on the identification of new compounds against schistosomiasis. Accordingly, the central objective of this proposal is to explore curcuminoid compounds to identify molecular prototypes for the future application as novels drugs to treat schsitosomiasis. The activities will be focused on synthesis of curcuminoids, and their in vitro and in vivo evaluation against two different strains of the S. mansoni parasite (Puerto Rican (maintained by Caffrey) and Luis Evangelista (maintained by Caldas). Class-specific effects and structure-activity relationships will also be addressed. Further, proteomic analysis and cytotoxicity will be evaluated in in vitro for those active anti-schistosomal compounds. Based on their in vitro performance, active compounds will be assessed for toxicity in vivo, as well as for their therapeutic potential in the experimental mouse model of schistosome infection. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAULA, LUCAS A. DE L.; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G. razilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine mode. Parasitology Research, v. 121, n. 2, p. 775-780, FEB 2022. Web of Science Citations: 0.
DE L. PAULA, LUCAS A.; CANDIDO, ANA C. B. B.; SANTOS, MARIO F. C.; CAFFREY, CONOR R.; BASTOS, JAIRO K.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G. Antiparasitic Properties of Propolis Extracts and Their Compounds. CHEMISTRY & BIODIVERSITY, v. 18, n. 9 JUL 2021. Web of Science Citations: 1.
A. DE L. PAULA, LUCAS; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; FALEIROS, RENATA; RAMOS, HENRIQUE P.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G. Uncovering Biological Application of Brazilian Green Propolis: A Phenotypic Screening againstSchistosoma mansoni. CHEMISTRY & BIODIVERSITY, v. 17, n. 9 AUG 2020. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.