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Assessment of inflammatory and functional features along with risk factors associated to chronic obstructive pulmonary disease of pediatric patients

Grant number: 16/22102-8
Support type:Regular Research Grants
Duration: July 01, 2018 - September 30, 2021
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal researcher:Adyléia Aparecida Dalbo Contrera Toro
Grantee:Adyléia Aparecida Dalbo Contrera Toro
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers: André Moreno Morcillo ; Antonio Fernando Ribeiro ; Jose Dirceu Ribeiro ; Maria Angela Gonçalves de Oliveira Ribeiro ; Maria de Fátima Corrêa Pimenta Servidoni ; Marina Simões Oliveira ; Natasha Yumi Matsunaga


Introduction: Chronic obstructive pulmonary diseases (COPDs) in pediatric patients, such as recurrent wheezing, asthma and cystic fibrosis are associated to higher demand from health system; costs of emergencies consults; medication for crisis; exacerbations and hospital admissions; and worst quality of life for patients and their families. Objective: To assess the inflammatory and functional features, and the risks factors associated to chronic obstructive pulmonary diseases in pediatric patients. Materials and methods: Prospective comparative study with infants, children and adolescents, aged 2 months to 17 years old, diagnosed with COPDs attending to the Outpatient Clinic Center from Clinics Hospital of University of Campinas (Unicamp). Parents and legal guardians will fill out an evaluation form with clinical and family history information. In order to assess cellularity and inflammatory profile, all patients will perform the sputum induction technique and blood draw, which will be used to eosinofil and neutrophil count; interleukine assessment using CBA kits and flow citometry; and vitamin D dosage. To assess the functional characteristic, spirometry and the Six Minute Walk Test will be performed in subjects 7 years and older. The collected data will be stored and analyzed by SPSS 16.0 Windows software (SPSS Inc., Chicago, IL; EUA) (p=5%). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATSUNAGA, NATASHA YUMI; GIANFRANCESCO, LIVEA; MAZZOLA, TAIS NITSCH; OLIVEIRA, MARINA SIMOES; MORCILLO, ANDRE MORENO; RIBEIRO, MARIA ANGELA GONCALVES OLIVEIRA; RIBEIRO, JOSE DIRCEU; HASHIMOTO, SIMONE; TORO, ADYLEIA APARECIDA DALBO CONTRERA. Differences between patients who achieved asthma control and those who remain uncontrolled after standardized severe asthma care strategy. JOURNAL OF ASTHMA, NOV 2020. Web of Science Citations: 0.
NATASHA YUMI MATSUNAGA; CAIO DE OLIVEIRA; LIVEA GIANFRANCESCO; MARINA SIMÕES OLIVEIRA; MARIA CRISTINA RIBEIRO DOS SANTOS SIMÕES; ANDRÉ MORENO MORCILLO; JOSÉ DIRCEU RIBEIRO; MARIA ANGELA GONÇALVES DE OLIVEIRA RIBEIRO; ADYLÉIA APARECIDA DALBO CONTRERA TORO. Avaliação do controle da asma entre diferentes medidas e avaliação da capacidade de exercício funcional em crianças e adolescentes com asma. Jornal Brasileiro de Pneumologia, v. 46, n. 3, p. -, 2020. Web of Science Citations: 0.

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