ACTION OF RED LED PHOTODYNAMIC THERAPYIN MICROORGANISM RELATED TO HALITOSE: CONTROLLED AND RANDOMIZED CLINICAL TRIAL.

Abstract

Halitosis is the term used to describe any unpleasant odor relative to expired air regardless of its source. The prevalence of halitosis in the population is approximately 30%, of which 80-90% of the cases originate in the oral cavity resulting from proteolytic degradation by gram negative anaerobic bacteria. Antimicrobial photodynamic therapy (aPDT) has been widely used and with quite satisfactory results in the health sciences, it involves the use of a non-toxic dye, called photosensitizer (FS), and a light source of a specific wavelength in the Presence of the oxygen in the medium. This interaction can create toxic species that generate cell death. The advantages of this approach are to avoid resistance to target bacteria and damage to adjacent tissues as the antimicrobial effect is confined only to the areas covered by the dye and irradiated by light Acting on the target organism quickly, depending on the dose of light energy and the power output used. The objective of this controlled clinical study is to verify the effect of aPDT in the treatment of halitosis by evaluating the formation of volatile sulfur compounds with gas chromatography and microbiological analysis before and after treatment. Will be included in this research young adults in the age group between 18 to 25 years with diagnosis of halitosis. The subjects selected will be divided into 3 groups, as described G1 aPDT, G2 tongue scraper and G3 aPDT and tongue scraper. All subjects will be submitted to microbiological analysis and evaluation with Oral ChromaTM before and after treatment. To evaluate the association of categorical variables, the chi-square test and Fisher's exact test will be used to compare the means will be used tStudent test and Analysis of variance (ANOVA) and to analyze the correlation between the continuous variables will be applied the correlation test By Pearson. In the analyzes of the experimental differences in each group the Wilcoxon test will be used. A significance level of 95% (p <0.05) will be considered for all analyzes. (AU)