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Development of new nanomaterials for nanomedicine applications

Abstract

Nanomedicine is expected to provide solutions to some of modern medicine's unsolved problems and offers new hopes in several critical areas such as cancer treatment, viral and bacterial infections, medical imaging, biosensors, tissue regeneration, and theranostics. The goal of the current project is the development of new biocompatible multifunctional nanomaterials based on acetalated-dextran nanoparticles, well-defined multifunctional dendrimers, gold dendronized nanoparticles, and injectable hydrogels, for application in nanomedicine. The project will focus on the synthesis of the new materials using innovative synthetic strategies based on orthogonality and click chemistry. Within this project we are proposing the design of biomaterials with potential activity in the treatment of cancer, bacterial infections and diseases caused by inflammation. The cytotoxicity of all the new nanomaterials will be tested against several cell lines in order to define if these materials are valid candidates for drug delivery platforms. (AU)

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VEICULO: TITULO (DATA)

Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRIGOLO, THIAGO A.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; RUSSOWSKY, DENNIS; FERREIRA-SILVA, GUILHERME A.; IONTA, MARISA; PILLI, RONALDO A.. Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents. BIOORGANIC CHEMISTRY, v. 116, . (17/06146-8, 18/02093-0, 13/07607-8, 19/13104-5)
DE SERRES-BERARD, THIERY; BECHER, TIAGO B.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; BERTHOD, FRANCOIS. Neuropeptide Substance P Released from a Nonswellable Laponite-Based Hydrogel Enhances Wound Healing in a Tissue-Engineered Skin In Vitro. ACS APPLIED POLYMER MATERIALS, v. 2, n. 12, p. 5790-5797, . (18/02093-0, 17/06146-8, 13/11519-7)
BECHER, TIAGO B.; BRAGA, CAROLYNE B.; BERTUZZI, DIEGO L.; RAMOS, JR., MIGUEL D.; HASSAN, AYAZ; CRESPILHO, FRANK N.; ORNELAS, CATIA. The structure-property relationship in LAPONITE (R) materials: from Wigner glasses to strong self-healing hydrogels formed by non-covalent interactions. SOFT MATTER, v. 15, n. 6, p. 1278-1289, . (13/14262-7, 18/02093-0, 13/11519-7, 16/25806-6, 15/16672-3, 15/04929-0)
MEIRELLES, MATHEUS A.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; PILLI, RONALDO A.. Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells. CHEMMEDCHEM, v. 14, n. 15, . (13/07607-8, 18/02093-0, 17/06146-8)
BERTUZZI, DIEGO L.; BECHER, TIAGO B.; CAPRETI, NAYLIL M. R.; AMORIM, JULIO; JURBERG, IGOR D.; MEGIATTO, JR., JACKSON D.; ORNELAS, CATIA. General Protocol to Obtain D-Glucosamine from Biomass Residues: Shrimp Shells, Cicada Sloughs and Cockroaches. GLOBAL CHALLENGES, v. 2, n. 11, . (18/02093-0, 15/04929-0, 17/24017-0, 14/15718-7, 13/22160-0)
DE SOUZA, VANESSA P.; SANTOS, FABIANO S.; RODEMBUSCH, FABIANO S.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; PILLI, RONALDO A.; RUSSOWSKY, DENNIS. Hybrid 3,4-dihydropyrimidin-2-(thi)ones as dual-functional bioactive molecules: fluorescent probes and cytotoxic agents to cancer cells. NEW JOURNAL OF CHEMISTRY, v. 44, n. 29, p. 12440-12451, . (17/06146-8, 19/13104-5, 18/02093-0)
PERLI, GABRIEL; WANG, QI; BRAGA, CAROLYNE B.; BERTUZZI, DIEGO L.; FONTANA, LINIQUER A.; SOARES, MARCO C. P.; RUIZ, JAIME; MEGIATTO, JR., JACKSON D.; ASTRUC, DIDIER; ORNELAS, CATIA. Self-Assembly of a Triazolylferrocenyl Dendrimer in Water Yields Nontraditional Intrinsic Green Fluorescent Vesosomes for Nanotheranostic Applications. Journal of the American Chemical Society, v. 143, n. 33, p. 12948-12954, . (18/02093-0, 13/22160-0, 21/00555-9, 17/06146-8)
GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; DA SILVA, LAURA C. E.; DE OLIVEIRA, MARCELO G.; ORNELAS, CATIA. Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity. ACS APPLIED POLYMER MATERIALS, v. 2, n. 5, p. 2027-2034, . (18/14142-5, 18/02093-0, 15/23761-2, 15/04929-0, 16/02414-5)
BRAGA, CAROLYNE B.; PERLI, GABRIEL; BECHER, TIAGO B.; OMELAS, CATIA. Biodegradable and pH-Responsive Acetalated Dextran (Ac-Dex) Nanoparticles for NIR Imaging and Controlled Delivery of a Platinum-Based Prodrug into Cancer Cells. MOLECULAR PHARMACEUTICS, v. 16, n. 5, p. 2083-2094, . (18/02093-0, 17/24488-3, 17/06146-8)
LIMA, MARIA L. S. O.; BRAGA, CAROLYNE B.; BECHER, TIAGO B.; ODRIOZOLA-GIMENO, MIKEL; TORRENT-SUCARRAT, MIQUEL; RIVILLA, IVAN; COSSIO, FERNANDO P.; MARSAIOLI, ANITA J.; ORNELAS, CATIA. Fluorescent Imidazo[1,2-a]pyrimidine Compounds as Biocompatible Organic Photosensitizers that Generate Singlet Oxygen: A Potential Tool for Phototheranostics. CHEMISTRY-A EUROPEAN JOURNAL, v. 27, n. 20, . (17/06146-8, 18/02093-0)
BRAGA, CAROLYNE B.; KIDO, LARISSA A.; LIMA, ELLEN N.; LAMAS, CELINA A.; CAGNON, VALERIA H. A.; ORNELAS, CATIA; PILLI, RONALDO A.. Enhancing the Anticancer Activity and Selectivity of Goniothalamin Using pH-Sensitive Acetalated Dextran (Ac-Dex) Nanoparticles: A Promising Platform for Delivery of Natural Compounds. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 6, n. 5, SI, p. 2929-2942, . (13/07607-8, 17/06146-8, 18/02093-0, 19/13104-5)
GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; ORNELAS, CATIA. Anti-inflammatory activity of polyamide dendrimers bearing bile acid termini synthesized via SPAAC. JOURNAL OF NANOPARTICLE RESEARCH, v. 21, n. 11, . (18/02093-0, 15/04929-0)
BERTUZZI, DIEGO L.; PERLI, GABRIEL; BRAGA, CAROLYNE B.; ORNELAS, CATIA. Synthesis, characterization, and anticancer activity of folate gamma-ferrocenyl conjugatest. NEW JOURNAL OF CHEMISTRY, v. 44, n. 12, p. 4694-4703, . (18/02093-0, 15/04929-0, 17/06146-8)
BECHER, TIAGO B.; MENDONCA, MONIQUE C. P.; DE FARIAS, MARCELO A.; PORTUGAL, V, RODRIGO; DE JESUS, MARCELO B.; ORNELAS, CATIA. Soft Nanohydrogels Based on Laponite Nanodiscs: A Versatile Drug Delivery Platform for Theranostics and Drug Cocktails. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 26, p. 21891-21900, . (16/03765-6, 13/11519-7, 14/03002-7, 18/02093-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

COMPOSTOS DERIVADOS DE ÁCIDOS BILIARES LIBERADORES DE ÓXIDO NÍTRICO, USOS DOS DITOS COMPOSTOS E PROCESSO DE PRODUÇÃO DOS DITOS COMPOSTOS BR1020200227173 - Universidade Estadual de Campinas (UNICAMP) . CÁTIA CRISTINA CAPÊLO ORNELAS MEGIATTO ; ANA MARIA GARZON PORRAS - November 2020, 06

DENDRÍMEROS POLIAMIDA HETEROFUNCIONALIZADOS, USO DOS REFERIDOS DENDRÍMEROS E PROCESSO DE OBTENÇÃO DE DENDRÍMEROS POLIAMIDA HETEROFUNCIONALIZADOS BR1020200227181 - Universidade Estadual de Campinas (UNICAMP) . CÁTIA CRISTINA CAPÊLO ORNELAS MEGIATTO ; ANA MARIA GARZON PORRAS - November 2020, 06