Agence Nationale de la Recherche (ANR) and the Blanc Program

• Abstract

  We hypothesize that the constitutive expression of one or more NADPH oxidase components and the function of the entire NADPH oxidase complex is dependent on IFN-gamma in human mocrophages and probably in dendritic cells. Thus, inborn errors of IFN-gamma responses in patients with Mendelian Susceptibility to Mycobacterial Infections (MSMD) with IFNGR deficiency should result in defective e…

  Human anti-tuberculous IFN-y-dependent immunity is mediated by the phagocytic NADPH oxidase, AP.R

• Abstract

  Chagas disease, caused by Trypanosoma cruzi, affects 15 million people; from these, 30% develop myocarditis and Chronic Chagas disease cardiomyopathy (CCC) while most patients remain asymptomatic (ASY). Familial aggregation of CCC cases and the association of single nucleotide polymorphisms (SNP) with CCC suggests a genetic component to disease susceptibility. The outcome of Chagas diseas…

  Identification of predictive / prognostic genetic signature in Chagas cardiomyopathy: a systems biology approach, AP.R

• Abstract

  Respiratory syncytial virus (RSV) is the chief worldwide viral cause of severe acute respiratory tract iIIness in infants and calves. After fifty years of research, there is still no vaccine available for humans. In such context, the development of antiviral drugs with a wide spectrum is an attractive and economical alternative to vaccination. RSV is an enveloped virus and its negative st…

  Chasing cellular partners of respiratory syncytial virus, AP.R

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