Instituto Jô Clemente

• Abstract

  Down Syndrome (DS) or trisomy 21 is the most common genetic cause of mild to moderate intellectual disability in the world. The life expectancy of DS patients has increased in the last decades and, therefore, the incidence of dementia, especially Alzheimer's Disease (AD) increases in this population, making aging a new and important area of study in DS. Molecular neuroimaging allows in vi…

  Translational neuroimaging in intellectual disability: evaluation of molecular changes associated with aging in Down Syndrome, AP.JP

• Resumo

  Down syndrome (DS), which is the consequence of the trisomy of chromosome 21 (T21), has an approximate incidence of 1:660 live births. DS is the most prevalent cause of intellectual disability of genetic origin and results in general cognitive impairment, which is typically in the mild-to-moderate range. Although DS has been known for over 160 years, our knowledge regarding the mechanisms…

  Generation of induced pluripotent stem cells from epithelial cells in urine from individuals with Down Syndrome, AP.JP

• Abstract

  The increase of life expectancy of the general population, with or without disabilities, brings comfort and new perspectives for people and their families. However, also creates concerns about the quality of life of those who .have some limitation in their autonomy. This way, it is fundamental to invest in research aimed at improving the quality of life and the promotion of independence i…

  Acquisition and improvement of executive functions: A program with emphasis on Independence and quality of life of adults with intellectual disabilities, AP.JP

• The development of the T21 Health and Development Checklist (CHECK-T21) for monitoring essential care for mothers and children with Down syndrome: São Paulo T21 Cohort, BP.TT
• São Paulo T21 Cohort technical training: Normative Growth Standards, BP.TT

• Abstract

  People with Down syndrome (DS) have chromosome 21 trisomy. This trisomy is considered to be the main reason for the high rate of onset of Alzheimer's disease in people with DS, and processes such as neuroinflammation and beta-amyloid plaque deposition are processes that happen during aging. It is possible to evaluate neuroinflammation by molecular imaging in vivo, using the positron emiss…

  Evaluation of 11C-PK11195 metabolites in venous blood of people with Down Syndrome, BP.IC

(Only some records are available in English at this moment)