GlaxoSmithKline
The agreement with GlaxoSmithKline - GSK aims to support a collaborative program to promote and to support research projects involving scientists working in public or private research or teaching institutions in the State of São Paulo, Brasil and scientists from GSK.
Immune based therapeutics such as checkpoint inhibitors have proven to work across several cancer types and the potential impact novel immuno-oncology targets can have on inducing anti-cancer responses, either as standalone, or as combination/adjuvant therapies is great. Thus, our central overriding scientific focus is to discover and validate immunoregulatory targets with the potential t…
CENTD's focus is to combine the expertise of researchers at the Butantan Institute (biochemistry, OMICS, molecular and cellular biology, pharmacology, genetics, bioinformatics, immunology, and in vitro and in vivo assays) with GSK's experience in the search and validation of new targets related to immune-inflammatory diseases, to enable the design and development of new therapeutic agents…
The purchase of this equipment will be of pivotal importance to all members of the CERSusChem to fulfill their basic needs of research, as the proposal aims the preparation, separation and identification of enantiomerically pure or chiral enriched substances. Therefore, we plan to use the ultra-performance liquid chromatography as analytical tool. This new technology provides both high sp…
High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells. Phenotypic changes may include incre…
The hybrid quadrupole-Orbitrap QExactive Plus mass spectrometer from Thermo Scientific will be used in all sub-projects within the main project "Rational approach for searching molecular targets involved in inflammatory events and cell survival" for protein identification through proteomics approach in complex sample. This last generation mass spectrometer will allow us to detect protein…
(Only some records are available in English at this moment)
There is still a significant portion of gynaecological cancer patients that do not respond well to immune-based cancer therapies. Results of a phase II clinical trial demonstrated the efficacy of the PD-1 inhibitor in advanced cervical cancer which led to Food and Drug Administration (FDA) approval. However, 5-year relative survival for these patients is still less than 20%. In ovarian ca…
The in vitro screening of natural and synthetic peptides derived from animal venoms to evaluate their cytoprotective and anti-inflammatory activities has contributed to the discovery of new pharmacological targets and the elucidation of pain and inflammation signaling pathways. Together with chemoproteomics assays, several peptides derived from Lonomia obliqua and Amblyomma cajennense wer…
(Only some records are available in English at this moment)
The role of the immune response in response to conventional cancer therapy and disease progression or recurrence has been well established for many cancers. The era of checkpoint inhibitors (anti-PD1, anti-CTLA-4, anti-PD-L1, and others) has ushered in novel therapies that aim to activate a previously inhibited anti-cancer T cell response by blocking inhibitory receptor engagement. While …
There is still a significant portion of gynaecological cancer patients that do not respond well to immune-based cancer therapies. Results of a phase II clinical trial demonstrated the efficacy of the PD-1 inhibitor in advanced cervical cancer which led to Food and Drug Administration (FDA) approval. However, 5-year relative survival for these patients is still less than 20%. In ovarian ca…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 9 / 9 | Completed research grants |
| 15 / 15 | Ongoing scholarships in Brazil |
| 48 / 45 | Completed scholarships in Brazil |
| 74 / 71 | All research grants and scholarships |
| Associated processes | |
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