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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Time-related immunomodulation by stressors and corticosterone transdermal application in toads

Texto completo
Autor(es):
Monteiro Titon, Stefanny Christie [1] ; Titon Jr, Braz ; Giorgi Barsotti, Adriana Maria [2] ; Gomes, Fernando Ribeiro [2] ; Assis, Vania Regina [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, SP - Brazil
[2] Titon Jr, Jr., Braz, Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 14, n. 9 SEP 20 2019.
Citações Web of Science: 1
Resumo

Immune responses have been mostly studied at a specific time in anuran species. However, time-changes related to immunomodulation associated with glucocorticoid (GC) alterations following stressors and GC treatment are complex. The present study describes time-related changes in immune response and corticosterone (CORT) plasma levels following restraint challenge, short, mid and long-term captivity, and CORT exogenous administration by transdermal application (TA) in Rhinella ornata toads. We observed increased neutrophil: lymphocyte ratios after restraint challenge and CORT TA, without changes following short and mid-term captivity. Plasma bacterial killing ability was sustained in all treatments, except long-term captivity, with decreased values after 90 days under such conditions. Phagocytic activity of peritoneal cells increased after mid-term captivity, and the phytohemagglutinin swelling response was impaired in those animals treated with CORT TA for 20 consecutive days. Plasma CORT levels increased or were sustained after restraint challenge (depending on initial values), decreased following mid and long-term captivity (for those animals showing high CORT in the field) and increased after 20 days of CORT TA. By performing assessments of time-changes in immune processes and CORT plasma levels in R. ornata, we demonstrate immuno-enhancing effects following restraint, short and mid-term stressors, while long-term stressors and CORT TA promoted immunosuppression in these toads. (AU)

Processo FAPESP: 11/10560-8 - Níveis plasmáticos de corticosterona, testosterona e imunocompetência em bufonídeos
Beneficiário:Vania Regina de Assis
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/05024-3 - Estresse hídrico e resposta imune em sapos (Rhinella ornata) habitando fragmentos de Floresta Atlântica
Beneficiário:Adriana Maria Giorgi Barsotti
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/16320-7 - Impactos das mudanças climáticas e ambientais sobre a fauna: uma abordagem integrativa
Beneficiário:Carlos Arturo Navas Iannini
Linha de fomento: Auxílio à Pesquisa - Programa de Pesquisa sobre Mudanças Climáticas Globais - Temático