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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The mitochondrial calcium uniporter complex in trypanosomes

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Autor(es):
Lander, Noelia [1] ; Chiurillo, Miguel A. [1] ; Bertolini, Mayara S. [1] ; Docampo, Roberto [2, 1] ; Vercesi, Anibal E. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Pathol Clin, Campinas, SP - Brazil
[2] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Cell Biology International; v. 42, n. 6, SI, p. 656-663, JUN 2018.
Citações Web of Science: 2
Resumo

The presence of a conserved mechanism for mitochondrial calcium uptake in trypanosomatids was crucial for the molecular identification of the mitochondrial calcium uniporter (MCU), a long-sought channel present in most eukaryotic organisms. Since then, research efforts to elucidate the role of MCU and its regulatory elements in different biological models have multiplied. MCU is the pore-forming subunit of a multimeric complex (the MCU complex or MCUC) and its predicted structure in trypanosomes is simpler than in mammalian cells, lacking two of its subunits and probably possessing other unidentified components. MCU protein has been characterized in Trypanosoma brucei and Trypanosoma cruzi, the causative agents of African and American trypanosomiasis, respectively. Contrary to its mammalian homolog, TbMCU was found to be essential for cell growth and survival, while its paralog MCUb is an essential protein in T. cruzi. These findings could be further exploited for chemotherapeutic purposes. The emergence of new molecular tools for the genetic manipulation of trypanosomatids has been determinant for the functional characterization of the MCUC components in these organisms. However, further research has to be done to determine the role of each component in intracellular calcium signaling and cell bioenergetics. In this mini-review we summarize the original results on mitochondrial calcium uptake in trypanosomes, how did they contribute to the molecular identification of the MCU, and the functional characterization of the MCUC subunits that has so far been studied in these peculiar eukaryotes. (AU)

Processo FAPESP: 13/50624-0 - Sinalização por íons de cálcio em tripanossomatídeos
Beneficiário:Roberto Docampo
Linha de fomento: Auxílio à Pesquisa - Programa SPEC
Processo FAPESP: 14/13148-9 - Sinalização por íons de cálcio em tripanossomatídeos
Beneficiário:Miguel Angel Chiurillo Siervo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/08995-4 - Sinalização por íons de cálcio em tripanosomatídeos
Beneficiário:Noelia Marina Lander Manfredi
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/25709-8 - Estudo funcional das proteínas MICU1 e MICU2 na sinalização por cálcio em Trypanosoma Cruzi
Beneficiário:Mayara Santos Bertolini
Linha de fomento: Bolsas no Brasil - Mestrado