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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fibrillar collagen genes are not coordinately upregulated with TGF beta 1 expression in finasteride-treated prostate

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Autor(es):
Delella, Flavia Karina [1] ; Alves de Almeida, Fernanda Losi [2] ; Nunes, Helga Caputo [1] ; Rinaldi, Jaqueline Carvalho [2] ; Felisbino, Sergio Luis [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[2] State Univ Maringa UEM, Biol Sci Ctr, Dept Morphol Sci, Maringa, Parana - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Cell Biology International; v. 41, n. 11, SI, p. 1214-1222, NOV 2017.
Citações Web of Science: 4
Resumo

Benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in older men. In this regard, recent studies have attempted to define the relationships between prostatic fibrosis, LUTS, and increased expression of transforming growth factor beta 1 (TGF beta 1) in BHP. Therapeutic approaches for BPH such as 5-alpha-reductase inhibitors and alpha-adrenergic blocking agents increase TGF beta 1 expression in the prostatic tissue. Here, we investigated the effects of the 5-alpha-reductase inhibitor-finasteride-on rat ventral prostate tissue, especially with regard to the tissue distribution and gene expression of fibrillar collagens. Adult Wistar rats (n = 15) were treated with finasteride (25 mg/kg/day) by subcutaneous injection for 7 and 30 days. Age-matched, vehicle-treated (n = 15) adult Wistar rats were used as control. Finasteride treatment reduced prostate size and increased the area of types I and III collagen fibers in the prostatic stroma. As expected, TGF b1 mRNA expression was upregulated by finasteride treatment. However, COL1A1 and COL3A1 mRNA expressions decreased after both 7 and 30 days of finasteride treatment, suggesting that finasteride treatment promotes prostate parenchyma and stroma changes, which lead to the observed types I and III collagen remodeling without de novo collagen synthesis. The upregulation of TGF beta 1mRNAand protein associated with the 5-alpha-reductase inhibitor is more closely related to epithelial and stromal cell death pathways than to prostatic fibrosis. (AU)

Processo FAPESP: 08/57906-3 - Instituto Nacional de Fotônica Aplicada à Biologia Celular - INFABIC
Beneficiário:Hernandes Faustino de Carvalho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 06/60114-6 - Efeito da finasterida e da doxazosina sobre os diferentes lobos da próstata de rato: análise ultraestrutural e da expressão dos colágenos tipo i e III e do TGF-beta 1
Beneficiário:Flávia Karina Delella
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 06/60116-9 - Efeito do diabete e da reposição com insulina sobre o processo de maturação da próstata ventral do rato Wistar: alterações morfológicas e na atividade de metaloproteinases de matriz MMP-2 e -9
Beneficiário:Elaine Manoela Porto
Linha de fomento: Bolsas no Brasil - Doutorado