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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Calcium signaling in trypanosomatid parasites

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Autor(es):
Docampo, Roberto [1, 2, 3] ; Huang, Guozhong [1, 2]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 - USA
[2] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 - USA
[3] Univ Estadual Campinas, Dept Clin Pathol, BR-13083 Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: Cell Calcium; v. 57, n. 3, SI, p. 194-202, MAR 2015.
Citações Web of Science: 22
Resumo

Calcium ion (Ca2+) is an important second messenger in trypanosomatids and essential for their survival although prolonged high intracellular Ca2+ levels lead to cell death. As other eukaiyotic cells, trypanosomes use two sources of Ca2+ for generating signals: Ca2+ release from intracellular stores and Ca2+ entry across the plasma membrane. Ca2+ release from intracellular stores is controlled by the inositol 1,4,5-trisphosphate receptor (IP3R) that is located in acidocalcisomes, acidic organelles that are the primary Ca2+ reservoir in these cells. A plasma membrane Ca2+-ATPase controls the cytosolic Ca2+ levels and a number of pumps and exchangers are responsible for Ca2+ uptake and release from intracellular compartments. The trypanosomatid genomes contain a wide variety of signaling and regulatory proteins that bind Ca2+ as well as many Ca2+-binding proteins that await further characterization. The mitochondrial Ca2+ transporters of trypanosomatids have an important role in the regulation of cell bioenergetics and flagellar Ca2+ appears to have roles in sensing the environment. In trypanosomatids in which an intracellular life cycle is present, Ca2+ signaling is important for host cell invasion. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 13/50624-0 - Sinalização por íons de cálcio em tripanossomatídeos
Beneficiário:Roberto Docampo
Linha de fomento: Auxílio à Pesquisa - Programa SPEC