Advanced search
Start date
Betweenand

Effects of marine pharmaceuticals in ZFL cell line

Grant number: 19/19939-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2019
Effective date (End): August 31, 2021
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Cooperation agreement: Fundação para a Ciência e a Tecnologia (FCT)
Principal Investigator:Leticia Veras Costa Lotufo
Grantee:Ives Charlie da Silva
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/07098-0 - Effects of marine pharmaceuticals in zebrafish and ZFL cell line - emphasis, AP.R

Abstract

Antineoplastics is one of the least studied groups concerning environmental impact and represent specific risks to aquatic species due to their mode of action. The questions addressed in the EMPHASIS project are: 1) Do they cause eco-, geno- and cytotoxicity to ZF? 2) What is their bioconcentration potential to ZF? 3) How do they affect the microbiota in ZF? and 4) How antineoplastic exposure alter the metabolic pathway in ZF? To address those questions, the project aims at evaluating the effects of clinic antineoplastics and novel compounds with anticancer properties using in vivo and in vitro models, the potential of cell lines to serve as alternative eco-toxicological models by validating them with the use of in vivo models and to evaluate and validate the ecotoxicological effects of new potential compounds when compared to clinic ones. The Adverse Outcome Pathway approach, will provide robust information linking different organizational levels for use in regulatory risk assessment. (AU)

Articles published in other media outlets (29 total):
More itemsLess items
Estadão.com: Aplicativo permite usar peixe paulistinha para diagnosticar a covid-19 (29/May/2020)
Mariani 24h: Aplicativo para diagnóstico da covid-19 (15/Aug/2020)
ASDB Notícias: Cientistas brasileiros desenvolvem aplicativo para diagnóstico da covid-19 (06/Jun/2020)
Portal R3: Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 (01/Jun/2020)
Ata News: Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 (01/Jun/2020)
Ternura FM: Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 (01/Jun/2020)
Folha Nobre: Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 | São Paulo (01/Jun/2020)
Região Noroeste : Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 (01/Jun/2020)
LabNetwork: Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 (01/Jun/2020)
Portal do Governo do Estado de São Paulo: Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 (01/Jun/2020)
Notícias de Campinas: Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 (01/Jun/2020)
Investe São Paulo: Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 (01/Jun/2020)
Plantão News (MT): Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 (30/May/2020)
BN - Bahia Notícias: USP desenvolve app que permite usar peixe paulistinha para diagnosticar Covid-19 (30/May/2020)
Planeta online: Aplicativo usa peixe paulistinha para diagnosticar covid-19 (30/May/2020)
Polinotícias: Aplicativo da USP permite usar peixe paulistinha para diagnosticar a COVID-19 (30/May/2020)
Portal Salvador Dez: USP desenvolve app que permite usar peixe paulistinha para diagnosticar Covid-19 (30/May/2020)
Terra: Aplicativo permite usar peixe paulistinha para diagnosticar a covid-19 (29/May/2020)
Jornais Virtuais: Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 (29/May/2020)
Revista Amazônia: Aplicativo permite usar peixe paulistinha para diagnosticar a covid-19 (29/May/2020)
Portal do Zacarias: Aplicativo permite usar peixe paulistinha para diagnosticar a covid (29/May/2020)
Central das Notícias: Aplicativo permite usar peixe paulistinha para diagnosticar a covid (29/May/2020)
Agrosoft: Aplicativo permite usar peixe paulistinha para diagnosticar a covid-19 (29/May/2020)
Panorama Farmacêutico: Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 (29/May/2020)
Esteta : Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 (29/May/2020)
Moodle Livre: Cientistas brasileiros desenvolvem aplicativo para diagnóstico da covid-19 (21/May/2020)
Pharma Innovation: Cientistas brasileiros desenvolvem aplicativo para diagnóstico da covid-19 (19/May/2020)
Medicina S/A: Zebrafish: diagnóstico da Covid-19 cinco vezes mais barato (19/May/2020)
Jornal da USP online: Pesquisadores da USP desenvolvem aplicativo para diagnóstico da covid-19 (18/May/2020)