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Impacts of genomic location in the evolution of tandem repetitive sequence

Grant number: 18/09760-1
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2018
Effective date (End): February 29, 2020
Field of knowledge:Biological Sciences - Genetics - Plant Genetics
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Mateus Mondin
Grantee:Gabriel Fernando da Silva
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil

Abstract

Satellite DNA (satDNAs) are highly repetitive sequences organized in large arrays in the genome. The nucleotides of these sequences there have a high rate of mutation controlled by an specific evolution mechanism called Molecular Drive (Concerted Evolution). There are no studies that explain the effect of genome location of the satellites DNA regarding its diversity and homogenization standard. The maize genome has at least four families of satDNAs: CentC, Cent4, TR-1 and 180-bp. The CentC and Cent4 are located in the centromeric region, and the TR-1 and 180-bp are located in the heterocromatin called knobs. The comparison of evolution standard between these satDNAs families located separated in the genome with clear different functions is fundamental for the understanding how the mechanism of concerted evolution operates. Therefore, the goal of this project is to understand the evolutionary behavior and the diversity of satDNAs families of the maize genome located in different heterocromatin regions.