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A systems approach to identify and validate novel therapeutic targets to improve cardiac repair and regeneration following myocardial infarction

Grant number: 16/50439-7
Support type:Regular Research Grants
Duration: August 01, 2017 - July 31, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Cooperation agreement: University of Virginia
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:José Eduardo Krieger
Grantee:José Eduardo Krieger
Principal investigator abroad: Jeff Sauceman
Institution abroad: University of Virginia (UVa), United States
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther, AP.TEM


The objective of this exchange proposal is to stimulate collaboration between a biomedical engineer Dr. Saucerman and a physiologist Dr. Krieger, both of which are developing therapies based on cardiac regeneration. Dr. Saucerman is well prepared to identify novel therapeutic targets using computational analysis of Dr. Krieger cardiac regeneration experiments. Likewise, Dr. Krieger is well prepared to validate targets predicted by Dr. Saucerman computational analyses using in vivo animal models of cardiac regeneration. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JENSEN, LEONARDO; NERI, ELIDA; BASSANEZE, VINICIUS; DE ALMEIDA OLIVEIRA, NATHALIA C.; DARIOLLI, RAFAEL; TURACA, LAURO T.; LEVY, DEBORA; VERONEZ, DOUGLAS; FERRAZ, MARIANA S. A.; ALENCAR, ADRIANO M.; BYDLOWSKI, SERGIO P.; CESTARI, IDAGENE A.; KRIEGER, JOSE EDUARDO. Integrated molecular, biochemical, and physiological assessment unravels key extraction method mediated influences on rat neonatal cardiomyocytes. Journal of Cellular Physiology, v. 233, n. 7, p. 5420-5430, JUL 2018. Web of Science Citations: 3.

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