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Advancing academic partnership in the discovery of anti malarial microbial metabolites of botanicals

Grant number: 17/50400-6
Support type:Regular Research Grants
Duration: December 01, 2018 - November 30, 2019
Field of knowledge:Biological Sciences - Parasitology
Cooperation agreement: Texas A&M University
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Fabio Trindade Maranhão Costa
Grantee:Fabio Trindade Maranhão Costa
Principal investigator abroad: Susanne Mertens-Talcott
Institution abroad: Texas A&M University, United States
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:12/16525-2 - Plasmodium vivax: pathogenesis and infectivity, AP.TEM


Malaria remains one of the leading causes of death by infectious diseases worldwide. In 2015, the WHO estimated 429,000 deaths from malaria. Around 99% of the deaths are caused by Plasmodium falciparum (Pf), which has become resistant to most conventional drugs. Therefore, there is an increased need to develop alternative treatment strategies. The partnership between Dr. Susanne Talcott and Dr. Fabio Costa started in 2015 through joining Dr. Talcott’s expertise in functional properties and pharmacometrics of botanicals and Dr. Costa's expertise in malaria research with a focus on alternative malaria treatment strategies to overcome drug resistance. Within this collaboration, previous funding through TAMU-CAPES has been successfully used to train students and perform research. Both investigators and their laboratories are in regular contact via skype, email and phone but the requested funding would enable face-to-face interactions in the preparation of grant applications, publications and mutual training opportunities. Current research includes the investigation of microbial metabolites of botanicals with cutting-edge technologies, including yeast-based high-throughput screening, genomic sequencing for molecular targets and resistance mechanisms. (AU)

Articles published in other media outlets (2 total):
Açaí berry extracts fight malaria in mice 
Açaí berry extracts fight malaria in mice 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, LETICIA T.; VENANCIO, VINICIUS P.; KAWANO, TAILA; ABRAO, LAILAH C. C.; TAVELLA, TATYANA A.; ALMEIDA, LUDIMILA D.; PIRES, GABRIEL S.; BILSLAND, ELIZABETH; SUNNERHAGEN, PER; AZEVEDO, LUCIANA; TALCOTT, STEPHEN T.; MERTENS-TALCOTT, SUSANNE U.; COSTA, FABIO T. M. Chemical Genomic Profiling Unveils the in Vitro and in Vivo Antiplasmodial Mechanism of Acai (Euterpe oleracea Mart.) Polyphenols. ACS OMEGA, v. 4, n. 13, p. 15628-15635, SEP 24 2019. Web of Science Citations: 0.

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